FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386494703> ?p ?o ?g. }

• W4386494703 abstract "Abstract Excess molybdenum (Mo) is harmful to animals, but its nephrotoxicity has not been comprehensively explained. To appraise the influences of excess Mo on Ca homeostasis and apoptosis via PLC/IP 3 /IP 3 R axis, primary duck renal tubular epithelial cells were exposed to 480 μM and 960 μM Mo, and joint of 960 μM Mo and 10 μM 2‐APB or 0.125 μM U‐73122 for 12 h (U‐73122 pretreated for 1 h), respectively. The data revealed that the increment of [Ca 2+ ] c induced by Mo mainly originated from intracellular Ca storage. Mo exposure reduced [Ca 2+ ] ER , elevated [Ca 2+ ] mit , [Ca 2+ ] c , and the expression of Ca homeostasis‐related factors (Calpain, CaN, CRT, GRP94, GRP78 and CaMKII). 2‐APB could effectively reverse subcellular Ca 2+ redistribution by inhibiting IP 3 R, which confirmed that [Ca 2+ ] c overload induced by Mo originated from ER. Additionally, PLC inhibitor U‐73122 remarkably mitigated the change, and dramatically reduced the number of apoptotic cells, the expression of Bak‐1, Bax, cleaved‐Caspase‐3/Caspase‐3, and notably increased the expression of Bcl‐xL, Bcl‐2, and Bcl‐2/Bax ratio. Overall, the results confirmed that the Ca 2+ liberation of ER via PLC/IP 3 /IP 3 R axis was the main cause of [Ca 2+ ] c overload, and then stimulated apoptosis in duck renal tubular epithelial cells." @default.
• W4386494703 created "2023-09-07" @default.
• W4386494703 creator A5013881064 @default.
• W4386494703 creator A5013982077 @default.
• W4386494703 creator A5022124135 @default.
• W4386494703 creator A5046941867 @default.
• W4386494703 creator A5053141547 @default.
• W4386494703 creator A5054191797 @default.
• W4386494703 creator A5063647575 @default.
• W4386494703 creator A5064631563 @default.
• W4386494703 creator A5079641647 @default.
• W4386494703 date "2023-09-07" @default.
• W4386494703 modified "2023-10-16" @default.
• W4386494703 title "Role of <scp>PLC</scp>/<scp>IP₃</scp>/<scp>IP₃R</scp> axis in excess molybdenum exposure induced apoptosis in duck renal tubular epithelial cells" @default.
• W4386494703 cites W1558565504 @default.
• W4386494703 cites W1974992308 @default.
• W4386494703 cites W1982599206 @default.
• W4386494703 cites W2007986411 @default.
• W4386494703 cites W2020025174 @default.
• W4386494703 cites W2026486305 @default.
• W4386494703 cites W2039674095 @default.
• W4386494703 cites W2061374493 @default.
• W4386494703 cites W2096329933 @default.
• W4386494703 cites W2115913010 @default.
• W4386494703 cites W2520486390 @default.
• W4386494703 cites W2532694670 @default.
• W4386494703 cites W2614467021 @default.
• W4386494703 cites W2623559108 @default.
• W4386494703 cites W2790222074 @default.
• W4386494703 cites W2790465369 @default.
• W4386494703 cites W2800420554 @default.
• W4386494703 cites W2890064317 @default.
• W4386494703 cites W2899521530 @default.
• W4386494703 cites W2900198026 @default.
• W4386494703 cites W2945420944 @default.
• W4386494703 cites W2971649607 @default.
• W4386494703 cites W2999181540 @default.
• W4386494703 cites W3009060308 @default.
• W4386494703 cites W3011728194 @default.
• W4386494703 cites W3032469607 @default.
• W4386494703 cites W3044421432 @default.
• W4386494703 cites W3049740821 @default.
• W4386494703 cites W3081794976 @default.
• W4386494703 cites W3095571237 @default.
• W4386494703 cites W3108943871 @default.
• W4386494703 cites W3210973676 @default.
• W4386494703 cites W3212942443 @default.
• W4386494703 cites W4200040355 @default.
• W4386494703 cites W4200086865 @default.
• W4386494703 cites W4200457513 @default.
• W4386494703 cites W4213324000 @default.
• W4386494703 cites W4220653856 @default.
• W4386494703 cites W4226120317 @default.
• W4386494703 cites W4281663048 @default.
• W4386494703 cites W4289793709 @default.
• W4386494703 cites W4292240714 @default.
• W4386494703 cites W4297235735 @default.
• W4386494703 cites W4303628715 @default.
• W4386494703 cites W4313252178 @default.
• W4386494703 doi "https://doi.org/10.1002/tox.23956" @default.
• W4386494703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37676969" @default.
• W4386494703 hasPublicationYear "2023" @default.
• W4386494703 type Work @default.
• W4386494703 citedByCount "1" @default.
• W4386494703 countsByYear W43864947032023 @default.
• W4386494703 crossrefType "journal-article" @default.
• W4386494703 hasAuthorship W4386494703A5013881064 @default.
• W4386494703 hasAuthorship W4386494703A5013982077 @default.
• W4386494703 hasAuthorship W4386494703A5022124135 @default.
• W4386494703 hasAuthorship W4386494703A5046941867 @default.
• W4386494703 hasAuthorship W4386494703A5053141547 @default.
• W4386494703 hasAuthorship W4386494703A5054191797 @default.
• W4386494703 hasAuthorship W4386494703A5063647575 @default.
• W4386494703 hasAuthorship W4386494703A5064631563 @default.
• W4386494703 hasAuthorship W4386494703A5079641647 @default.
• W4386494703 hasBestOaLocation W43864947031 @default.
• W4386494703 hasConcept C153911025 @default.
• W4386494703 hasConcept C181199279 @default.
• W4386494703 hasConcept C185592680 @default.
• W4386494703 hasConcept C190283241 @default.
• W4386494703 hasConcept C55493867 @default.
• W4386494703 hasConcept C56928146 @default.
• W4386494703 hasConcept C63645605 @default.
• W4386494703 hasConcept C79879829 @default.
• W4386494703 hasConcept C86803240 @default.
• W4386494703 hasConcept C95444343 @default.
• W4386494703 hasConceptScore W4386494703C153911025 @default.
• W4386494703 hasConceptScore W4386494703C181199279 @default.
• W4386494703 hasConceptScore W4386494703C185592680 @default.
• W4386494703 hasConceptScore W4386494703C190283241 @default.
• W4386494703 hasConceptScore W4386494703C55493867 @default.
• W4386494703 hasConceptScore W4386494703C56928146 @default.
• W4386494703 hasConceptScore W4386494703C63645605 @default.
• W4386494703 hasConceptScore W4386494703C79879829 @default.
• W4386494703 hasConceptScore W4386494703C86803240 @default.
• W4386494703 hasConceptScore W4386494703C95444343 @default.
• W4386494703 hasFunder F4320321001 @default.
• W4386494703 hasLocation W43864947031 @default.
• W4386494703 hasLocation W43864947032 @default.
• W4386494703 hasOpenAccess W4386494703 @default.

• next