FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386496487> ?p ?o ?g. }

• W4386496487 endingPage "6495" @default.
• W4386496487 startingPage "6495" @default.
• W4386496487 abstract "Chemotherapy-related anemia is prevalent in up to 75% of patients, which may arise due to hemolysis and eryptosis. Alpha-mangostin (α-MG) is a polyphenolic xanthonoid found in the mangosteen tree (Garcinia mangostana) whose antitumor medicinal properties are well-established. Nevertheless, the potential toxic effects of α-MG on red blood cells (RBCs) have, as of yet, not been as well studied.RBCs were exposed to 1-40 μM of α-MG for 24 h at 37 °C. Hemolysis and related markers were measured using colorimetric assays, eryptotic cells were identified through Annexin-V-FITC, Ca2+ was detected with Fluo4/AM, and oxidative stress was assessed through H2DCFDA using flow cytometry. The toxicity of α-MG was also examined in the presence of specific signal transduction inhibitors and in whole blood.α-MG at 10-40 μM caused dose-dependent hemolysis with concurrent significant elevation in K+, Mg2+, and LDH leakage, but at 2.5 μM it significantly increased the osmotic resistance of cells. A significant increase was also noted in Annexin-V-binding cells, along with intracellular Ca2+, oxidative stress, and cell shrinkage. Moreover, acetylcholinesterase activity was significantly inhibited by α-MG, whose hemolytic potential was significantly ameliorated by the presence of BAPTA-AM, vitamin C, NSC23766, and isosmotic sucrose but not urea. In whole blood, α-MG significantly depleted intracellular hemoglobin stores and was selectively toxic to platelets and monocytes.α-MG possesses hemolytic and eryptotic activities mediated through Ca2+ signaling, Rac1 GTPase activity, and oxidative injury. Also, α-MG leads to accelerated cellular aging and specifically targets platelet and monocyte populations in a whole blood milieu." @default.
• W4386496487 created "2023-09-07" @default.
• W4386496487 creator A5066311967 @default.
• W4386496487 creator A5074340324 @default.
• W4386496487 creator A5080347865 @default.
• W4386496487 date "2023-09-07" @default.
• W4386496487 modified "2023-10-17" @default.
• W4386496487 title "Stimulation of Hemolysis and Eryptosis by α-Mangostin through Rac1 GTPase and Oxidative Injury in Human Red Blood Cells" @default.
• W4386496487 cites W1671518868 @default.
• W4386496487 cites W1757857404 @default.
• W4386496487 cites W1920794742 @default.
• W4386496487 cites W1968412972 @default.
• W4386496487 cites W1987807963 @default.
• W4386496487 cites W1990714537 @default.
• W4386496487 cites W2018573355 @default.
• W4386496487 cites W2022154881 @default.
• W4386496487 cites W2037211493 @default.
• W4386496487 cites W2049797149 @default.
• W4386496487 cites W2053620862 @default.
• W4386496487 cites W2077089856 @default.
• W4386496487 cites W2088483617 @default.
• W4386496487 cites W2096173332 @default.
• W4386496487 cites W2096563333 @default.
• W4386496487 cites W2132855703 @default.
• W4386496487 cites W2132966139 @default.
• W4386496487 cites W2133817220 @default.
• W4386496487 cites W2163830215 @default.
• W4386496487 cites W2277907718 @default.
• W4386496487 cites W2314075508 @default.
• W4386496487 cites W2535718410 @default.
• W4386496487 cites W2602017356 @default.
• W4386496487 cites W2617393486 @default.
• W4386496487 cites W2620887170 @default.
• W4386496487 cites W2747962095 @default.
• W4386496487 cites W2751506677 @default.
• W4386496487 cites W2792373351 @default.
• W4386496487 cites W2801688576 @default.
• W4386496487 cites W2903244340 @default.
• W4386496487 cites W2992371251 @default.
• W4386496487 cites W2999723972 @default.
• W4386496487 cites W3000970827 @default.
• W4386496487 cites W3008161823 @default.
• W4386496487 cites W3037174575 @default.
• W4386496487 cites W3041608326 @default.
• W4386496487 cites W3109003668 @default.
• W4386496487 cites W3198553162 @default.
• W4386496487 cites W4210650043 @default.
• W4386496487 cites W4319159815 @default.
• W4386496487 cites W4321503570 @default.
• W4386496487 cites W4323362777 @default.
• W4386496487 cites W4362523622 @default.
• W4386496487 cites W4379057737 @default.
• W4386496487 cites W4385224883 @default.
• W4386496487 cites W4385897835 @default.
• W4386496487 doi "https://doi.org/10.3390/molecules28186495" @default.
• W4386496487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37764276" @default.
• W4386496487 hasPublicationYear "2023" @default.
• W4386496487 type Work @default.
• W4386496487 citedByCount "0" @default.
• W4386496487 crossrefType "journal-article" @default.
• W4386496487 hasAuthorship W4386496487A5066311967 @default.
• W4386496487 hasAuthorship W4386496487A5074340324 @default.
• W4386496487 hasAuthorship W4386496487A5080347865 @default.
• W4386496487 hasBestOaLocation W43864964871 @default.
• W4386496487 hasConcept C185592680 @default.
• W4386496487 hasConcept C203014093 @default.
• W4386496487 hasConcept C2776151105 @default.
• W4386496487 hasConcept C2776557347 @default.
• W4386496487 hasConcept C2779902561 @default.
• W4386496487 hasConcept C55493867 @default.
• W4386496487 hasConcept C79879829 @default.
• W4386496487 hasConcept C86803240 @default.
• W4386496487 hasConcept C98274493 @default.
• W4386496487 hasConceptScore W4386496487C185592680 @default.
• W4386496487 hasConceptScore W4386496487C203014093 @default.
• W4386496487 hasConceptScore W4386496487C2776151105 @default.
• W4386496487 hasConceptScore W4386496487C2776557347 @default.
• W4386496487 hasConceptScore W4386496487C2779902561 @default.
• W4386496487 hasConceptScore W4386496487C55493867 @default.
• W4386496487 hasConceptScore W4386496487C79879829 @default.
• W4386496487 hasConceptScore W4386496487C86803240 @default.
• W4386496487 hasConceptScore W4386496487C98274493 @default.
• W4386496487 hasIssue "18" @default.
• W4386496487 hasLocation W43864964871 @default.
• W4386496487 hasLocation W43864964872 @default.
• W4386496487 hasOpenAccess W4386496487 @default.
• W4386496487 hasPrimaryLocation W43864964871 @default.
• W4386496487 hasRelatedWork W1972912540 @default.
• W4386496487 hasRelatedWork W1980549483 @default.
• W4386496487 hasRelatedWork W1996374427 @default.
• W4386496487 hasRelatedWork W2037127584 @default.
• W4386496487 hasRelatedWork W2057294638 @default.
• W4386496487 hasRelatedWork W2079044938 @default.
• W4386496487 hasRelatedWork W2113533986 @default.
• W4386496487 hasRelatedWork W2152677811 @default.
• W4386496487 hasRelatedWork W3020033093 @default.
• W4386496487 hasRelatedWork W2522908311 @default.
• W4386496487 hasVolume "28" @default.

• next