Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386496583> ?p ?o ?g. }
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- W4386496583 abstract "Genome-wide association studies of blood pressure (BP) have identified >1,000 loci, but the effector genes and biological pathways at these loci are mostly unknown. Using published association summary statistics, we conducted annotation-informed fine-mapping incorporating tissue-specific chromatin segmentation and colocalization to identify causal variants and candidate effector genes for systolic BP, diastolic BP, and pulse pressure. We observed 532 distinct signals associated with ≥2 BP traits and 84 with all three. For >20% of signals, a single variant accounted for >75% posterior probability, 65 were missense variants in known (SLC39A8, ADRB2, and DBH) and previously unreported BP candidate genes (NRIP1 and MMP14). In disease-relevant tissues, we colocalized >80 and >400 distinct signals for each BP trait with cis-eQTLs and regulatory regions from promoter capture Hi-C, respectively. Integrating mouse, human disorder, gene expression and tissue abundance data, and literature review, we provide consolidated evidence for 436 BP candidate genes for future functional validation and discover several potential drug targets." @default.
- W4386496583 created "2023-09-07" @default.
- W4386496583 creator A5009823534 @default.
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- W4386496583 date "2023-10-01" @default.
- W4386496583 modified "2023-10-10" @default.
- W4386496583 title "Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension" @default.
- W4386496583 cites W1537435549 @default.
- W4386496583 cites W1911952697 @default.
- W4386496583 cites W1969353942 @default.
- W4386496583 cites W1979594866 @default.
- W4386496583 cites W1984036044 @default.
- W4386496583 cites W1985282324 @default.
- W4386496583 cites W2002122781 @default.
- W4386496583 cites W2007160086 @default.
- W4386496583 cites W2009165570 @default.
- W4386496583 cites W2012409690 @default.
- W4386496583 cites W2024537012 @default.
- W4386496583 cites W2041600962 @default.
- W4386496583 cites W2044707173 @default.
- W4386496583 cites W2048184316 @default.
- W4386496583 cites W2060754299 @default.
- W4386496583 cites W2073836327 @default.
- W4386496583 cites W2076154138 @default.
- W4386496583 cites W2082704080 @default.
- W4386496583 cites W2096465161 @default.
- W4386496583 cites W2096791516 @default.
- W4386496583 cites W2101605059 @default.
- W4386496583 cites W2102619694 @default.
- W4386496583 cites W2104570606 @default.
- W4386496583 cites W2107237646 @default.
- W4386496583 cites W2109434294 @default.
- W4386496583 cites W2127915286 @default.
- W4386496583 cites W2129254992 @default.
- W4386496583 cites W2145215852 @default.
- W4386496583 cites W2147215182 @default.
- W4386496583 cites W2151666848 @default.
- W4386496583 cites W2152325859 @default.
- W4386496583 cites W2152885121 @default.
- W4386496583 cites W2154331071 @default.
- W4386496583 cites W2158621858 @default.
- W4386496583 cites W2259938310 @default.
- W4386496583 cites W2410866878 @default.
- W4386496583 cites W2462900154 @default.
- W4386496583 cites W2474747771 @default.
- W4386496583 cites W2511515754 @default.
- W4386496583 cites W2518986366 @default.
- W4386496583 cites W2519445944 @default.
- W4386496583 cites W2519483107 @default.
- W4386496583 cites W2531097770 @default.
- W4386496583 cites W2544192593 @default.
- W4386496583 cites W2557097554 @default.
- W4386496583 cites W2558586574 @default.
- W4386496583 cites W2572331255 @default.
- W4386496583 cites W2581452190 @default.
- W4386496583 cites W2586625056 @default.
- W4386496583 cites W2770092353 @default.
- W4386496583 cites W2777132446 @default.
- W4386496583 cites W2787258762 @default.
- W4386496583 cites W2789833091 @default.
- W4386496583 cites W2806225217 @default.
- W4386496583 cites W2883415719 @default.
- W4386496583 cites W2900255713 @default.
- W4386496583 cites W2903782905 @default.
- W4386496583 cites W2912214881 @default.
- W4386496583 cites W2915985519 @default.
- W4386496583 cites W2921359953 @default.
- W4386496583 cites W2921517507 @default.
- W4386496583 cites W2951276412 @default.
- W4386496583 cites W2952013316 @default.
- W4386496583 cites W2955994579 @default.
- W4386496583 cites W2966788525 @default.
- W4386496583 cites W2975589949 @default.
- W4386496583 cites W2977238725 @default.
- W4386496583 cites W2978585643 @default.
- W4386496583 cites W2996409665 @default.
- W4386496583 cites W3036049370 @default.
- W4386496583 cites W3046366876 @default.
- W4386496583 cites W3088401235 @default.
- W4386496583 cites W3092861045 @default.
- W4386496583 cites W3103797259 @default.
- W4386496583 cites W3109183357 @default.
- W4386496583 cites W3120229635 @default.
- W4386496583 cites W3127556601 @default.
- W4386496583 cites W3133859624 @default.
- W4386496583 cites W3157419338 @default.
- W4386496583 cites W3160269084 @default.
- W4386496583 cites W3202209876 @default.
- W4386496583 cites W3207912190 @default.
- W4386496583 cites W3215894083 @default.
- W4386496583 cites W4211177544 @default.