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- W4386497940 abstract "Abstract Objective To compare the predictive performance for delivery with preeclampsia (PE) within 2 weeks of assessment in women with chronic hypertension at 24‐41 weeks’ gestation between serum glycosylated fibronectin (GlyFn) concentration, serum placental growth factor (PlGF) concentration and soluble fms‐like tyrosine kinase‐1 (sFLT‐1) / PlGF concentration ratio. Methods This was a prospective study in 104 women with singleton pregnancies and chronic hypertension presenting at 24‐41 weeks’ gestation. In 26 (25.0%) cases there was superimposed PE within 2 weeks from sampling. We compared the predictive performance for superimposed PE between GlyFn, PlGF and sFLT‐1 / PlGF at fixed screen positive rates of approximately 10%. Results The median gestational age at sampling was 34.1 (31.5, 35.6) weeks and in 84.6% (88/104) of cases it was <36 weeks. The predictive performance for superimposed PE of the three methods of screening was similar with detection rates of about 23‐27%, at screen positive rate of 11% and false positive rate of about 5%. Conclusion GlyFn is a simple point‐of‐care test without the need of a laboratory and can provide results within 10 minutes of testing. In this respect it may potentially replace the angiogenic markers that are currently used in the prediction of imminent PE in high‐risk women. However, neither GlyFn nor angiogenic factors are likely to improve the management of women with chronic hypertension, because their predictive performance for superimposed PE is poor. This article is protected by copyright. All rights reserved." @default.
- W4386497940 created "2023-09-07" @default.
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- W4386497940 date "2023-09-07" @default.
- W4386497940 modified "2023-09-26" @default.
- W4386497940 title "Prediction of superimposed pre‐eclampsia by serum glycosylated fibronectin and angiogenic factors in women with chronic hypertension" @default.
- W4386497940 doi "https://doi.org/10.1002/uog.27475" @default.
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- W4386497940 hasPublicationYear "2023" @default.
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