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• W4386499291 abstract "The development of wearable bioelectronic systems is a promising approach for optimal delivery of therapeutic treatments. These systems can provide continuous delivery of ions, charged biomolecules, and an electric field for various medical applications. However, rapid prototyping of wearable bioelectronic systems for controlled delivery of specific treatments with a scalable fabrication process is challenging. We present a wearable bioelectronic system comprised of a polydimethylsiloxane (PDMS) device cast in customizable 3D printed molds and a printed circuit board (PCB), which employs commercially available engineering components and tools throughout design and fabrication. The system, featuring solution-filled reservoirs, embedded electrodes, and hydrogel-filled capillary tubing, is assembled modularly. The PDMS and PCB both contain matching through-holes designed to hold metallic contact posts coated with silver epoxy, allowing for mechanical and electrical integration. This assembly scheme allows us to interchange subsystem components, such as various PCB designs and reservoir solutions. We present three PCB designs: a wired version and two battery-powered versions with and without onboard memory. The wired design uses an external voltage controller for device actuation. The battery-powered PCB design uses a microcontroller unit to enable pre-programmed applied voltages and deep sleep mode to prolong battery run time. Finally, the battery-powered PCB with onboard memory is developed to record delivered currents, which enables us to verify treatment dose delivered. To demonstrate the functionality of the platform, the devices are used to deliver H[Formula: see text] in vivo using mouse models and fluoxetine ex vivo using a simulated wound environment. Immunohistochemistry staining shows an improvement of 35.86% in the M1/M2 ratio of H[Formula: see text]-treated wounds compared with control wounds, indicating the potential of the platform to improve wound healing." @default.
• W4386499291 created "2023-09-07" @default.
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• W4386499291 date "2023-09-07" @default.
• W4386499291 modified "2023-10-15" @default.
• W4386499291 title "A system for bioelectronic delivery of treatment directed toward wound healing" @default.
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• W4386499291 cites W1936204324 @default.
• W4386499291 cites W1963963199 @default.
• W4386499291 cites W1964989471 @default.
• W4386499291 cites W1978609960 @default.
• W4386499291 cites W1979644915 @default.
• W4386499291 cites W1997657967 @default.
• W4386499291 cites W2025138472 @default.
• W4386499291 cites W2026671183 @default.
• W4386499291 cites W2030281917 @default.
• W4386499291 cites W2048672935 @default.
• W4386499291 cites W2051013988 @default.
• W4386499291 cites W2057139842 @default.
• W4386499291 cites W2059345407 @default.
• W4386499291 cites W2063789567 @default.
• W4386499291 cites W2082042446 @default.
• W4386499291 cites W2088006716 @default.
• W4386499291 cites W2097534444 @default.
• W4386499291 cites W2118654016 @default.
• W4386499291 cites W2127394904 @default.
• W4386499291 cites W2144874527 @default.
• W4386499291 cites W2149409343 @default.
• W4386499291 cites W2152417357 @default.
• W4386499291 cites W2155490506 @default.
• W4386499291 cites W2160956551 @default.
• W4386499291 cites W2206596356 @default.
• W4386499291 cites W2325727928 @default.
• W4386499291 cites W2481237472 @default.
• W4386499291 cites W2768565458 @default.
• W4386499291 cites W2790790333 @default.
• W4386499291 cites W2795019883 @default.
• W4386499291 cites W2809781849 @default.
• W4386499291 cites W2893814198 @default.
• W4386499291 cites W2895321679 @default.
• W4386499291 cites W2898809225 @default.
• W4386499291 cites W2903161243 @default.
• W4386499291 cites W2903334735 @default.
• W4386499291 cites W2909962767 @default.
• W4386499291 cites W2942540986 @default.
• W4386499291 cites W2945687731 @default.
• W4386499291 cites W2965235368 @default.
• W4386499291 cites W2968874011 @default.
• W4386499291 cites W2969783033 @default.
• W4386499291 cites W2986432149 @default.
• W4386499291 cites W3014705201 @default.
• W4386499291 cites W3037714890 @default.
• W4386499291 cites W3037825798 @default.
• W4386499291 cites W3086053922 @default.
• W4386499291 cites W3102433126 @default.
• W4386499291 cites W3113175246 @default.
• W4386499291 cites W3119424459 @default.
• W4386499291 cites W3130694515 @default.
• W4386499291 cites W3143156272 @default.
• W4386499291 cites W3154445566 @default.
• W4386499291 cites W3155761141 @default.
• W4386499291 cites W3157767428 @default.
• W4386499291 cites W3160247959 @default.
• W4386499291 cites W3199607110 @default.
• W4386499291 cites W3203381395 @default.
• W4386499291 cites W3203463952 @default.
• W4386499291 cites W34912133 @default.
• W4386499291 cites W4200502753 @default.
• W4386499291 cites W4205928681 @default.
• W4386499291 cites W4214555582 @default.
• W4386499291 cites W4281722258 @default.
• W4386499291 cites W4283321474 @default.
• W4386499291 cites W4304701054 @default.
• W4386499291 cites W4310058384 @default.
• W4386499291 cites W4311522751 @default.
• W4386499291 cites W4327892811 @default.
• W4386499291 cites W4360828136 @default.
• W4386499291 doi "https://doi.org/10.1038/s41598-023-41572-w" @default.
• W4386499291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37679425" @default.
• W4386499291 hasPublicationYear "2023" @default.
• W4386499291 type Work @default.

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