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- W4386502015 abstract "Reading is involved in various daily activities that operate under a wide range of luminance levels. Rod- and cone-mediated mesopic visual function is known to be impaired even in early/intermediate age-related macular degeneration (AMD). It remains unclear whether and to what extent mesopic reading is impaired in early/intermediate AMD. Here, we assessed differences in reading vision between photopic and mesopic conditions in early/intermediate AMD and compared their performance to those in older adults with normal macular health.The study included 30 patients with early/intermediate AMD and 30 healthy controls. Reading performance was tested on the MNREAD iPad app under mesopic (2 cd/m2 with a neural-density filter) and photopic (220 cd/m2) conditions. Four reading indices-maximum reading speed (MRS), critical print size (CPS), reading acuity (RA), and reading accessibility index (ACC)-were obtained from the MNREAD test, yielding a function representing reading speed versus print size.Compared to photopic conditions, patients with AMD and healthy controls both exhibited noticeable decreases in reading vision under mesopic conditions (P < 0.001) despite normal photopic visual acuity. This decrease was more pronounced in AMD even after adjusting for age (P < 0.001): Under mesopic conditions, MRS and ACC decreased by 8 words per minute and 0.1, respectively; CPS and RA were enlarged by 0.27 and 0.24 logMAR, respectively.Reading vision deteriorates under mesopic conditions compared to photopic conditions in early/intermediate AMD and is accentuated compared to this difference in healthy controls.A mesopic reading test may provide a more sensitive and comprehensive assessment of a patient's reading impairment." @default.
- W4386502015 created "2023-09-08" @default.
- W4386502015 creator A5009198945 @default.
- W4386502015 creator A5054726987 @default.
- W4386502015 date "2023-09-07" @default.
- W4386502015 modified "2023-09-29" @default.
- W4386502015 title "Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions" @default.
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- W4386502015 doi "https://doi.org/10.1167/tvst.12.9.7" @default.
- W4386502015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37676678" @default.
- W4386502015 hasPublicationYear "2023" @default.
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