FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386504405> ?p ?o ?g. }

• W4386504405 abstract "Abstract Background T2D is of high prevalence in the middle east and thus studying its mechanisms is of a significant importance. Using 1026 Qatar BioBank samples, epigenetics, whole genome sequencing and metabolomics were combined to further elucidate the biological mechanisms of T2D in a population with a high prevalence of T2D. Methods An epigenome-wide association study (EWAS) with T2D was performed using the Infinium 850K EPIC array, followed by whole genome-wide sequencing SNP-CpG association analysis (> 5.5 million SNPs) and a methylome-metabolome (CpG-metabolite) analysis of the identified T2D sites. Results A total of 66 T2D-CpG associations were identified, including 63 novel sites in pathways of fructose and mannose metabolism, insulin signaling, galactose, starch and sucrose metabolism, and carbohydrate absorption and digestion. Whole genome SNP associations with the 66 CpGs resulted in 688 significant CpG-SNP associations comprising 22 unique CpGs (33% of the 66 CPGs) and included 181 novel pairs or pairs in novel loci. Fourteen of the loci overlapped published GWAS loci for diabetes related traits and were used to identify causal associations of HK1 and PFKFB2 with HbA1c. Methylome-metabolome analysis identified 66 significant CpG-metabolite pairs among which 61 pairs were novel. Using the identified methylome-metabolome associations, methylation QTLs, and metabolic networks, a multi-omics network was constructed which suggested a number of metabolic mechanisms underlying T2D methylated genes. 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) – a triglyceride-associated metabolite, shared a common network with 13 methylated CpGs, including TXNIP, PFKFB2, OCIAD1, and BLCAP. Mannonate – a food component/plant shared a common network with 6 methylated genes, including TXNIP, BLCAP, THBS4 and PEF1, pointing to a common possible cause of methylation in those genes. A subnetwork with alanine, glutamine, urea cycle (citrulline, arginine), and 1-carboxyethylvaline linked to PFKFB2 and TXNIP revealed associations with kidney function, hypertension and triglyceride metabolism. The pathway containing STYXL1-POR was associated with a sphingosine-ceramides subnetwork associated with HDL-C and LDL-C and point to steroid perturbations in T2D. Conclusions This study revealed several novel methylated genes in T2D, with their genomic variants and associated metabolic pathways with several implications for future clinical use of multi-omics associations in disease and for studying therapeutic targets." @default.
• W4386504405 created "2023-09-08" @default.
• W4386504405 creator A5034861279 @default.
• W4386504405 creator A5079820394 @default.
• W4386504405 creator A5080950140 @default.
• W4386504405 date "2023-09-08" @default.
• W4386504405 modified "2023-10-15" @default.
• W4386504405 title "Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study" @default.
• W4386504405 cites W1808248494 @default.
• W4386504405 cites W1925664165 @default.
• W4386504405 cites W1936841329 @default.
• W4386504405 cites W1974603403 @default.
• W4386504405 cites W1988291375 @default.
• W4386504405 cites W2004170579 @default.
• W4386504405 cites W2005421391 @default.
• W4386504405 cites W2016141072 @default.
• W4386504405 cites W2018607502 @default.
• W4386504405 cites W2035293214 @default.
• W4386504405 cites W2039153962 @default.
• W4386504405 cites W2047783882 @default.
• W4386504405 cites W2067613113 @default.
• W4386504405 cites W2070050178 @default.
• W4386504405 cites W2103714979 @default.
• W4386504405 cites W2129915465 @default.
• W4386504405 cites W2132464305 @default.
• W4386504405 cites W2133520037 @default.
• W4386504405 cites W2136634207 @default.
• W4386504405 cites W2141128375 @default.
• W4386504405 cites W2146019031 @default.
• W4386504405 cites W2149378411 @default.
• W4386504405 cites W2161245845 @default.
• W4386504405 cites W2169374003 @default.
• W4386504405 cites W2279723444 @default.
• W4386504405 cites W2293182033 @default.
• W4386504405 cites W2316239158 @default.
• W4386504405 cites W2345356016 @default.
• W4386504405 cites W2461793432 @default.
• W4386504405 cites W2466928446 @default.
• W4386504405 cites W2474747771 @default.
• W4386504405 cites W2483146391 @default.
• W4386504405 cites W2560048039 @default.
• W4386504405 cites W2752931625 @default.
• W4386504405 cites W2767825002 @default.
• W4386504405 cites W2768591422 @default.
• W4386504405 cites W2775065465 @default.
• W4386504405 cites W2787215053 @default.
• W4386504405 cites W2790653691 @default.
• W4386504405 cites W2807643570 @default.
• W4386504405 cites W2894662039 @default.
• W4386504405 cites W2896399639 @default.
• W4386504405 cites W2898279930 @default.
• W4386504405 cites W2901303766 @default.
• W4386504405 cites W2923389938 @default.
• W4386504405 cites W2929942943 @default.
• W4386504405 cites W2949112115 @default.
• W4386504405 cites W2952217637 @default.
• W4386504405 cites W2973820537 @default.
• W4386504405 cites W2997086972 @default.
• W4386504405 cites W3010892452 @default.
• W4386504405 cites W3085845732 @default.
• W4386504405 cites W3090627945 @default.
• W4386504405 cites W3095452393 @default.
• W4386504405 cites W3107720246 @default.
• W4386504405 cites W3111797598 @default.
• W4386504405 cites W3113959678 @default.
• W4386504405 cites W3132172325 @default.
• W4386504405 cites W3197990766 @default.
• W4386504405 cites W3210686555 @default.
• W4386504405 cites W4200026682 @default.
• W4386504405 cites W4206259166 @default.
• W4386504405 cites W4223600979 @default.
• W4386504405 cites W4229336798 @default.
• W4386504405 cites W4304187454 @default.
• W4386504405 cites W4361277813 @default.
• W4386504405 cites W4362673659 @default.
• W4386504405 cites W76271618 @default.
• W4386504405 doi "https://doi.org/10.1186/s12916-023-03027-x" @default.
• W4386504405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37679740" @default.
• W4386504405 hasPublicationYear "2023" @default.
• W4386504405 type Work @default.
• W4386504405 citedByCount "0" @default.
• W4386504405 crossrefType "journal-article" @default.
• W4386504405 hasAuthorship W4386504405A5034861279 @default.
• W4386504405 hasAuthorship W4386504405A5079820394 @default.
• W4386504405 hasAuthorship W4386504405A5080950140 @default.
• W4386504405 hasBestOaLocation W43865044051 @default.
• W4386504405 hasConcept C104317684 @default.
• W4386504405 hasConcept C106208931 @default.
• W4386504405 hasConcept C117717151 @default.
• W4386504405 hasConcept C135763542 @default.
• W4386504405 hasConcept C135870905 @default.
• W4386504405 hasConcept C140173407 @default.
• W4386504405 hasConcept C150194340 @default.
• W4386504405 hasConcept C153209595 @default.
• W4386504405 hasConcept C190727270 @default.
• W4386504405 hasConcept C21565614 @default.
• W4386504405 hasConcept C2908647359 @default.
• W4386504405 hasConcept C54355233 @default.
• W4386504405 hasConcept C60644358 @default.
• W4386504405 hasConcept C70721500 @default.

• next