Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386506890> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4386506890 endingPage "195016" @default.
- W4386506890 startingPage "195016" @default.
- W4386506890 abstract "Trans-arterial radioembolization (TARE) is an intra-arterial treatment method for liver malignancies. In this procedure, the therapeutic tumor dose is significant for predicting the treatment effectiveness while the dose absorbed in an organ at risk provides an understanding of its tolerance to radiation. This study proposes a Monte Carlo (MC) approach for determining absorbed organ doses for patients undergoing TARE treatment. The technique is based on the use of a voxel-based partial body model generated for each patient from his/her anatomical image data to represent the critical body structures more realistically. These structures are first segmented from image slices to create an image block which is then incorporated into a radiation transport package (MCNP6.2) to perform MC simulations. When used along with the parameters specific to a patient's treatment, such as lung-shunt factor, tumor-to-normal liver ratio, fractional uptakes, and administered activity, this approach allowed more accurate simulation of radiation interactions and hence provided absorbed doses specific to a TARE patient. The MC method also calculated the absorbed doses in organs or tissues that were close to target tissues for which the Medical Internal Radiation Dose Committee (MIRD) formalism makes no predictions. MIRD calculations were found to overestimate the absorbed doses by as much as 11% in lungs, 5% in liver, and 20% in tumor volumes. This raises concerns about the treatment's efficacy when estimating the correct activity to be administered to a patient. When each patient simulation was repeated with a90Y source spectrum to reflect the distribution of varying beta energies, the liver and the lungs were observed to receive relatively lower doses than those obtained with monoenergetic beta particles. Thus, it can be stated that the approach adopted in this study offers a more precise model of the patient's critical tissues and serves as a personalized dosimetric tool for TARE treatment planning." @default.
- W4386506890 created "2023-09-08" @default.
- W4386506890 creator A5037799774 @default.
- W4386506890 creator A5059556430 @default.
- W4386506890 creator A5092768729 @default.
- W4386506890 date "2023-09-25" @default.
- W4386506890 modified "2023-09-27" @default.
- W4386506890 title "A personalized Monte Carlo study of tumor and critical organ doses for Trans-arterial Radioembolization patients" @default.
- W4386506890 cites W1972656626 @default.
- W4386506890 cites W1984327976 @default.
- W4386506890 cites W1990623839 @default.
- W4386506890 cites W2025540628 @default.
- W4386506890 cites W2065241241 @default.
- W4386506890 cites W2067351259 @default.
- W4386506890 cites W2075985036 @default.
- W4386506890 cites W2093940036 @default.
- W4386506890 cites W2121685666 @default.
- W4386506890 cites W2137052325 @default.
- W4386506890 cites W2157040169 @default.
- W4386506890 cites W2167279371 @default.
- W4386506890 cites W2297372456 @default.
- W4386506890 cites W2315340853 @default.
- W4386506890 cites W2551923905 @default.
- W4386506890 cites W2730576610 @default.
- W4386506890 cites W2768996390 @default.
- W4386506890 cites W2990244017 @default.
- W4386506890 cites W3128646645 @default.
- W4386506890 cites W3135807925 @default.
- W4386506890 cites W4280583295 @default.
- W4386506890 cites W4286602766 @default.
- W4386506890 doi "https://doi.org/10.1088/1361-6560/acf7a7" @default.
- W4386506890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37678259" @default.
- W4386506890 hasPublicationYear "2023" @default.
- W4386506890 type Work @default.
- W4386506890 citedByCount "0" @default.
- W4386506890 crossrefType "journal-article" @default.
- W4386506890 hasAuthorship W4386506890A5037799774 @default.
- W4386506890 hasAuthorship W4386506890A5059556430 @default.
- W4386506890 hasAuthorship W4386506890A5092768729 @default.
- W4386506890 hasConcept C105795698 @default.
- W4386506890 hasConcept C126838900 @default.
- W4386506890 hasConcept C151337348 @default.
- W4386506890 hasConcept C19499675 @default.
- W4386506890 hasConcept C2910230993 @default.
- W4386506890 hasConcept C2989005 @default.
- W4386506890 hasConcept C33923547 @default.
- W4386506890 hasConcept C509974204 @default.
- W4386506890 hasConcept C54170458 @default.
- W4386506890 hasConcept C71924100 @default.
- W4386506890 hasConcept C75088862 @default.
- W4386506890 hasConceptScore W4386506890C105795698 @default.
- W4386506890 hasConceptScore W4386506890C126838900 @default.
- W4386506890 hasConceptScore W4386506890C151337348 @default.
- W4386506890 hasConceptScore W4386506890C19499675 @default.
- W4386506890 hasConceptScore W4386506890C2910230993 @default.
- W4386506890 hasConceptScore W4386506890C2989005 @default.
- W4386506890 hasConceptScore W4386506890C33923547 @default.
- W4386506890 hasConceptScore W4386506890C509974204 @default.
- W4386506890 hasConceptScore W4386506890C54170458 @default.
- W4386506890 hasConceptScore W4386506890C71924100 @default.
- W4386506890 hasConceptScore W4386506890C75088862 @default.
- W4386506890 hasIssue "19" @default.
- W4386506890 hasLocation W43865068901 @default.
- W4386506890 hasLocation W43865068902 @default.
- W4386506890 hasOpenAccess W4386506890 @default.
- W4386506890 hasPrimaryLocation W43865068901 @default.
- W4386506890 hasRelatedWork W1964713829 @default.
- W4386506890 hasRelatedWork W2045815051 @default.
- W4386506890 hasRelatedWork W2105853795 @default.
- W4386506890 hasRelatedWork W2417083896 @default.
- W4386506890 hasRelatedWork W2512421757 @default.
- W4386506890 hasRelatedWork W2923700792 @default.
- W4386506890 hasRelatedWork W2995221510 @default.
- W4386506890 hasRelatedWork W3212156328 @default.
- W4386506890 hasRelatedWork W4286565478 @default.
- W4386506890 hasRelatedWork W4292104215 @default.
- W4386506890 hasVolume "68" @default.
- W4386506890 isParatext "false" @default.
- W4386506890 isRetracted "false" @default.
- W4386506890 workType "article" @default.