FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386506918> ?p ?o ?g. }

• W4386506918 abstract "Abstract The vaginal bacterial community plays a crucial role in preventing infections. The composition of this community can be classified into five main groups, termed community state types (CSTs). Four of these CSTs, which are primarily consisted of Lactobacillus species, are considered healthy, while the fifth, which is composed of non-Lactobacillus populations, is considered less protective. This latter CST is often considered to represent a state termed Bacterial vaginosis (BV) – a common disease condition associated with unpleasant symptoms and increased susceptibility to sexually transmitted diseases. However, the exact mechanisms underlying BV development are not yet fully understood, including specifically, the dynamics of the vaginal microbiome in BV, and the possible routes it may take from a healthy to a BV state. This study aims to identify the progression from healthy Lactobacillus-dominant populations to symptomatic BV by analyzing 8,026 vaginal samples and using a manifold-detection framework. This approach is inspired by single-cell analysis and aims to identify low-dimensional trajectories in the high-dimensional composition space. This framework further order samples along these trajectories and assign a score (pseudo-time) to each sample based on its proximity to the BV state. Our results reveal distinct routes of progression between healthy and BV state for each CST, with pseudo-time scores correlating with community diversity and quantifying the health state of each sample. BV indicators, including Nugent score, positive Amsel’s test, and several Amsel’s criteria, can also be successfully predicted based on pseudo-time scores. Additionally, Gardnerella vaginalis can be identified as a key taxon in BV development using this approach, with increased abundance in samples with high pseudo-time, indicating an unhealthier state across all BV-development routes on the manifold. Taken together, these findings demonstrate how manifold detection can be used to successfully characterizes the progression from healthy Lactobacillus-dominant populations to BV and to accurately quantify the health condition of new samples along the route of BV development." @default.
• W4386506918 created "2023-09-08" @default.
• W4386506918 creator A5058236568 @default.
• W4386506918 creator A5067539705 @default.
• W4386506918 date "2023-09-06" @default.
• W4386506918 modified "2023-09-29" @default.
• W4386506918 title "A Manifold-Based Framework for Studying the Dynamics of the Vaginal Microbiome" @default.
• W4386506918 cites W1480172732 @default.
• W4386506918 cites W1548772785 @default.
• W4386506918 cites W1584857512 @default.
• W4386506918 cites W1947830296 @default.
• W4386506918 cites W2003585812 @default.
• W4386506918 cites W2013371150 @default.
• W4386506918 cites W2022111190 @default.
• W4386506918 cites W2027297424 @default.
• W4386506918 cites W2028835702 @default.
• W4386506918 cites W2034285706 @default.
• W4386506918 cites W2042782086 @default.
• W4386506918 cites W2059234851 @default.
• W4386506918 cites W2071460665 @default.
• W4386506918 cites W2083618864 @default.
• W4386506918 cites W2106258306 @default.
• W4386506918 cites W2122071767 @default.
• W4386506918 cites W2136432779 @default.
• W4386506918 cites W2152885278 @default.
• W4386506918 cites W2158902491 @default.
• W4386506918 cites W2159595761 @default.
• W4386506918 cites W2310269848 @default.
• W4386506918 cites W2401404581 @default.
• W4386506918 cites W2509957998 @default.
• W4386506918 cites W2526724898 @default.
• W4386506918 cites W2559683962 @default.
• W4386506918 cites W2776140326 @default.
• W4386506918 cites W2787201588 @default.
• W4386506918 cites W2788450097 @default.
• W4386506918 cites W2792633644 @default.
• W4386506918 cites W2796470921 @default.
• W4386506918 cites W2801244393 @default.
• W4386506918 cites W2810460765 @default.
• W4386506918 cites W2889326414 @default.
• W4386506918 cites W2911005883 @default.
• W4386506918 cites W2913064993 @default.
• W4386506918 cites W2913474831 @default.
• W4386506918 cites W2917576966 @default.
• W4386506918 cites W2921973735 @default.
• W4386506918 cites W2927507212 @default.
• W4386506918 cites W2947640277 @default.
• W4386506918 cites W2947787281 @default.
• W4386506918 cites W2950372712 @default.
• W4386506918 cites W2952261006 @default.
• W4386506918 cites W2966771290 @default.
• W4386506918 cites W2977541623 @default.
• W4386506918 cites W2977871370 @default.
• W4386506918 cites W3010324698 @default.
• W4386506918 cites W3010746544 @default.
• W4386506918 cites W3014744244 @default.
• W4386506918 cites W3041058329 @default.
• W4386506918 cites W3094066492 @default.
• W4386506918 cites W3100302535 @default.
• W4386506918 cites W3108137971 @default.
• W4386506918 cites W3110164307 @default.
• W4386506918 cites W3133829926 @default.
• W4386506918 cites W3182730896 @default.
• W4386506918 cites W3217215100 @default.
• W4386506918 cites W4214847726 @default.
• W4386506918 cites W4214858973 @default.
• W4386506918 cites W4280493115 @default.
• W4386506918 cites W4289855726 @default.
• W4386506918 cites W4381334960 @default.
• W4386506918 doi "https://doi.org/10.1101/2023.09.06.556518" @default.
• W4386506918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37732273" @default.
• W4386506918 hasPublicationYear "2023" @default.
• W4386506918 type Work @default.
• W4386506918 citedByCount "0" @default.
• W4386506918 crossrefType "posted-content" @default.
• W4386506918 hasAuthorship W4386506918A5058236568 @default.
• W4386506918 hasAuthorship W4386506918A5067539705 @default.
• W4386506918 hasBestOaLocation W43865069181 @default.
• W4386506918 hasConcept C143121216 @default.
• W4386506918 hasConcept C2777744392 @default.
• W4386506918 hasConcept C2779952448 @default.
• W4386506918 hasConcept C2780018483 @default.
• W4386506918 hasConcept C2780206646 @default.
• W4386506918 hasConcept C523546767 @default.
• W4386506918 hasConcept C54355233 @default.
• W4386506918 hasConcept C60644358 @default.
• W4386506918 hasConcept C71924100 @default.
• W4386506918 hasConcept C86803240 @default.
• W4386506918 hasConcept C89423630 @default.
• W4386506918 hasConceptScore W4386506918C143121216 @default.
• W4386506918 hasConceptScore W4386506918C2777744392 @default.
• W4386506918 hasConceptScore W4386506918C2779952448 @default.
• W4386506918 hasConceptScore W4386506918C2780018483 @default.
• W4386506918 hasConceptScore W4386506918C2780206646 @default.
• W4386506918 hasConceptScore W4386506918C523546767 @default.
• W4386506918 hasConceptScore W4386506918C54355233 @default.
• W4386506918 hasConceptScore W4386506918C60644358 @default.
• W4386506918 hasConceptScore W4386506918C71924100 @default.
• W4386506918 hasConceptScore W4386506918C86803240 @default.
• W4386506918 hasConceptScore W4386506918C89423630 @default.

• next