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• W4386507060 abstract "Background In this study, we aimed to explore the antihypertensive effect of 23 and 52% concentrations of low-sodium salt combined with the Chinese Modified Dietary Approaches to Stop Hypertension (CM-DASH) diet in patients with hypertension and type 2 diabetes. Methods We conducted a randomized controlled single-blind trial with a semi-open design. One hundred and thirty-two participants were randomly assigned into Group A (control group), Group B (52% low-sodium salt group), Group C (23% low-sodium salt group), and Group D (meal pack group) for 8 weeks of dietary intervention. All participants were followed weekly to collect data on blood pressure, salt use, and adverse events. Blood and 24-h urine samples were analyzed at baseline, 4 weeks, and the end of the intervention. Results At the end of the intervention, the mean blood pressure decreased significantly by 10.81/5.03 mmHg, 14.32/6.32 mmHg, 14.20/6.59 mmHg, and 19.06/7.82 mmHg in Groups A–D, respectively, compared with baseline ( p &lt; 0.001). Comparison between groups showed that the systolic blood pressure was lower in Groups C and D than in Groups A (−6.54 mmHg, −8.70 mmHg, p &lt; 0.05) and B (−6.60 mmHg, −8.76 mmHg, p &lt; 0.05), and the diastolic blood pressure was lower in Group D than in Group A (−5.17 mmHg, p = 0.006). The 24-h urinary Na + and Na + /K + values were significantly decreased in participants using low-sodium salt ( p &lt; 0.001). No serious adverse events occurred during the trial. Conclusion Our preliminary results suggest that 23 and 52% concentrations of low-sodium salt combined with the CM-DASH diet can effectively reduce sodium intake and increase potassium intake in patients with hypertension and type 2 diabetes mellitus, thus achieving “salt reduction” and attaining standard, smooth, comprehensive management of patients with hypertension and type 2 diabetes. Clinical trial registration http://www.chictr.org.cn/ , ChiCTR2000029017." @default.
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• W4386507060 date "2023-09-07" @default.
• W4386507060 modified "2023-09-27" @default.
• W4386507060 title "Novel low-sodium salt formulations combined with Chinese modified DASH diet for reducing blood pressure in patients with hypertension and type 2 diabetes: a clinical trial" @default.
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• W4386507060 doi "https://doi.org/10.3389/fnut.2023.1219381" @default.
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