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- W4386508540 abstract "To render protein drugs more suitable for clinical treatment, PEGylation has been widely used to ameliorate their inherent deficiencies, such as poor stability, rapid elimination in the bloodstream, and high immunogenicity. While increasingly PEGylated protein drugs have been approved by the FDA, the non-degradability of PEG and the emergence of anti-PEG antibodies after injection raise concerns about their cumulative chronic toxicity and long-term therapeutic efficacy. Zwitterionic polymer, with a unique structure containing equal amounts of positively charged and negatively charged groups, shows a different hydration behavior to PEG, which may be a superior PEG alternative for protein conjugation. In this concept review, a series of features beyond that of PEGylated protein exhibited by protein-zwitterionic polymer conjugate are discussed and some suggestions are presented for their future direction." @default.
- W4386508540 created "2023-09-08" @default.
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- W4386508540 date "2023-09-20" @default.
- W4386508540 modified "2023-10-18" @default.
- W4386508540 title "Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG" @default.
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- W4386508540 doi "https://doi.org/10.1002/cmdc.202300245" @default.
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