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- W4386516259 abstract "Gonadal hormones function in the retina; however, their targets have not yet been identified. Therefore, the present study examined the effects of progesterone and other gonadal hormones on glutamatergic circuits in the retina.Extracellular glutamate concentrations, which correspond to the amount of glutamate released, were examined using an enzyme-linked fluorescent assay system. The activity of glutamatergic synapses between bipolar cells and ganglion cells was investigated using a patch clamp technique. Changes in retinal thickness during pregnancy were assessed using optical coherence tomography (OCT) images.Progesterone and pregnenolone sulfate increased extracellular glutamate concentrations, whereas estrogen and testosterone did not. Progesterone increased the activity of glutamatergic synapses between bipolar cells and ganglion cells. A temporal decrease in the thickness of the peripheral retina was observed in the 1st trimester.Progesterone, but not estrogen or testosterone, activated glutamate release in the mouse retina. Increases in the concentration of progesterone during pregnancy did not induce any detectable change in retinal thickness." @default.
- W4386516259 created "2023-09-08" @default.
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- W4386516259 date "2023-08-25" @default.
- W4386516259 modified "2023-09-29" @default.
- W4386516259 title "Effects of Progesterone and Other Gonadal Hormones on Glutamatergic Circuits in the Retina" @default.
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- W4386516259 doi "https://doi.org/10.1272/jnms.jnms.2023_90-405" @default.
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