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- W4386518544 abstract "Blocking the PI3K/Akt pathway has been widely recognized as an attractive cancer therapeutic strategy because of its crucial role in cell growth and survival. This study presents the synthesis of 24 new 5-Methoxy-6-substituted-1H-benzimidazole derivatives (4a-4x) and the evaluation of their anti-proliferative activities against A549, Siha, MCF-7, HepG2, PC3, and HCT-116 tumor cell lines through MTT assay. Compound 4w exhibited superior anti-tumor activity against the A549 cells with IC50 values of 1.55 ± 0.18 μM, and better than the BKM120 (IC50 = 9.75 ± 1.25 µM). Further studies indicated that 4w could induce G0/G1 phase arrest, cell apoptosis, and down-regulate expression of p-PI3K and p-Akt. These results indicate that 4w could be served as a lead compound of PI3K inhibitor for the treatment of human lung cancers." @default.
- W4386518544 created "2023-09-08" @default.
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- W4386518544 date "2023-10-01" @default.
- W4386518544 modified "2023-10-15" @default.
- W4386518544 title "Design, synthesis and antitumor effects of novel benzoimidazole derivatives as PI3K inhibitors" @default.
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- W4386518544 doi "https://doi.org/10.1016/j.bmcl.2023.129469" @default.
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