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• W4386520925 endingPage "103792" @default.
• W4386520925 startingPage "103792" @default.
• W4386520925 abstract "The tumor microenvironment (TME) represents a barrier to PDT efficacy among melanoma patients. The aim of this study is to employ a novel muti-tactic TME-remodeling strategy via repolarization of tumor-associated macrophages (TAMs), the main TME immune cells in melanoma, from the pro-tumor M2 into the antitumor M1 phenotype using Phoenix dactylifera L. (date palm) in combination with PDT.Screening of different date cultivars was employed to choose extracts of selective toxicity to melanoma and TAMs, not normal macrophages. Potential extracts were then fractionated and characterized by gas chromatography-mass spectrometry (GC-MS). Finally, the efficacy and the potential molecular mechanism of the co-treatment were portrayed via quantitative real-time polymerase chain reaction (qRT-PCR) analysis.Initial screening resulted in the selection of the two Phoenix dactylifera L. cultivars Safawi and Sukkari methanolic extracts. Sukkari showed superior capacity to revert TAM phenotype into M1 as well as more prominent upregulation of M1 markers and repression of melanoma immunosuppressive markers relative to positive control (resiquimod). Molecularly, it was shown that PDT of melanoma cells in the presence of the secretome of repolarized TAMs surpassed the monotherapy via the modulation of the H19/iNOS/PD-L1immune-regulatory axis.This study highlights the potential utilization of nutraceuticals in combination with PDT in the treatment of melanoma to provide a dual activity through alleviating the immune suppressive TME and potentiating the anti-tumor responses." @default.
• W4386520925 created "2023-09-08" @default.
• W4386520925 creator A5009963718 @default.
• W4386520925 creator A5022423433 @default.
• W4386520925 creator A5024881937 @default.
• W4386520925 creator A5039825342 @default.
• W4386520925 date "2023-12-01" @default.
• W4386520925 modified "2023-10-02" @default.
• W4386520925 title "“Phytochemical-derived Tumor-Associated Macrophage Remodeling Strategy using Phoenix dactylifera L. Boosted Photodynamic Therapy in Melanoma via H19/iNOS/PD-L1 Axis”" @default.
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