FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386523631> ?p ?o ?g. }

• W4386523631 abstract "Hypoxemia in fibrotic interstitial lung disease (ILD) indicates disease progression and is of prognostic significance. The onset of hypoxemia signifies disease progression and predicts mortality in fibrotic interstitial lung diseases (ILD). Accurately predicting new-onset exertional and resting hypoxemia prompts appropriate patient discussion and timely consideration of home oxygen.We derived and externally validated a risk prediction tool for both new-onset exertional and resting hypoxemia.This study used ILD registries from Canada for the derivation cohort and from Australia and United States for the validation cohort. New-onset exertional and resting hypoxemia were defined as nadir SpO2 <88% during 6-minute walk tests, resting SpO2 <88%, or the initiation of ambulatory or continuous oxygen. Candidate predictors included patient demographics, ILD subtypes, and pulmonary function. Time-varying Cox regression was used to identify the top performing prediction model according to Akaike information criterion and clinical usability. Model performance was assessed using Harrell's C-index and goodness-of-fit (GoF) likelihood ratio test. A categorized risk prediction tool was developed.The best-performing prediction model for both new-onset exertional and resting hypoxemia included age, body mass index, a diagnosis of idiopathic pulmonary fibrosis, and percent-predicted forced vital capacity and diffusing capacity of carbon monoxide. The risk prediction tool exhibited good performance for exertional hypoxemia (C-index=0.70, GoF=0.85) and resting hypoxemia (C-index=0.77, GoF=0.27) in the derivation cohort, with similar performance in the validation cohort except calibration for resting hypoxemia (GoF=0.001).This clinically applicable risk prediction tool predicted new-onset exertional and resting hypoxemia at six months in the derivation cohort and a diverse validation cohort. Suboptimal GoF in the validation cohort likely reflected overestimation of hypoxemia risk and indicated that the model is not flawed due to underestimation of hypoxemia." @default.
• W4386523631 created "2023-09-08" @default.
• W4386523631 creator A5001470140 @default.
• W4386523631 creator A5002523848 @default.
• W4386523631 creator A5004657168 @default.
• W4386523631 creator A5009091055 @default.
• W4386523631 creator A5009862886 @default.
• W4386523631 creator A5011774869 @default.
• W4386523631 creator A5016809126 @default.
• W4386523631 creator A5017763972 @default.
• W4386523631 creator A5019434255 @default.
• W4386523631 creator A5022407246 @default.
• W4386523631 creator A5023270797 @default.
• W4386523631 creator A5025045708 @default.
• W4386523631 creator A5030988190 @default.
• W4386523631 creator A5033032729 @default.
• W4386523631 creator A5033382458 @default.
• W4386523631 creator A5044533146 @default.
• W4386523631 creator A5054075627 @default.
• W4386523631 creator A5063687930 @default.
• W4386523631 creator A5071091208 @default.
• W4386523631 creator A5072315274 @default.
• W4386523631 creator A5074594962 @default.
• W4386523631 creator A5078877643 @default.
• W4386523631 creator A5085602260 @default.
• W4386523631 creator A5086902392 @default.
• W4386523631 creator A5091415199 @default.
• W4386523631 date "2023-09-07" @default.
• W4386523631 modified "2023-10-16" @default.
• W4386523631 title "Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease" @default.
• W4386523631 doi "https://doi.org/10.1513/annalsats.202303-208oc" @default.
• W4386523631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37676933" @default.
• W4386523631 hasPublicationYear "2023" @default.
• W4386523631 type Work @default.
• W4386523631 citedByCount "0" @default.
• W4386523631 crossrefType "journal-article" @default.
• W4386523631 hasAuthorship W4386523631A5001470140 @default.
• W4386523631 hasAuthorship W4386523631A5002523848 @default.
• W4386523631 hasAuthorship W4386523631A5004657168 @default.
• W4386523631 hasAuthorship W4386523631A5009091055 @default.
• W4386523631 hasAuthorship W4386523631A5009862886 @default.
• W4386523631 hasAuthorship W4386523631A5011774869 @default.
• W4386523631 hasAuthorship W4386523631A5016809126 @default.
• W4386523631 hasAuthorship W4386523631A5017763972 @default.
• W4386523631 hasAuthorship W4386523631A5019434255 @default.
• W4386523631 hasAuthorship W4386523631A5022407246 @default.
• W4386523631 hasAuthorship W4386523631A5023270797 @default.
• W4386523631 hasAuthorship W4386523631A5025045708 @default.
• W4386523631 hasAuthorship W4386523631A5030988190 @default.
• W4386523631 hasAuthorship W4386523631A5033032729 @default.
• W4386523631 hasAuthorship W4386523631A5033382458 @default.
• W4386523631 hasAuthorship W4386523631A5044533146 @default.
• W4386523631 hasAuthorship W4386523631A5054075627 @default.
• W4386523631 hasAuthorship W4386523631A5063687930 @default.
• W4386523631 hasAuthorship W4386523631A5071091208 @default.
• W4386523631 hasAuthorship W4386523631A5072315274 @default.
• W4386523631 hasAuthorship W4386523631A5074594962 @default.
• W4386523631 hasAuthorship W4386523631A5078877643 @default.
• W4386523631 hasAuthorship W4386523631A5085602260 @default.
• W4386523631 hasAuthorship W4386523631A5086902392 @default.
• W4386523631 hasAuthorship W4386523631A5091415199 @default.
• W4386523631 hasConcept C126322002 @default.
• W4386523631 hasConcept C16020263 @default.
• W4386523631 hasConcept C164705383 @default.
• W4386523631 hasConcept C165637977 @default.
• W4386523631 hasConcept C2776779939 @default.
• W4386523631 hasConcept C2777543607 @default.
• W4386523631 hasConcept C2777714996 @default.
• W4386523631 hasConcept C2778341716 @default.
• W4386523631 hasConcept C2780221984 @default.
• W4386523631 hasConcept C3018587741 @default.
• W4386523631 hasConcept C50382708 @default.
• W4386523631 hasConcept C55520419 @default.
• W4386523631 hasConcept C71924100 @default.
• W4386523631 hasConcept C72563966 @default.
• W4386523631 hasConceptScore W4386523631C126322002 @default.
• W4386523631 hasConceptScore W4386523631C16020263 @default.
• W4386523631 hasConceptScore W4386523631C164705383 @default.
• W4386523631 hasConceptScore W4386523631C165637977 @default.
• W4386523631 hasConceptScore W4386523631C2776779939 @default.
• W4386523631 hasConceptScore W4386523631C2777543607 @default.
• W4386523631 hasConceptScore W4386523631C2777714996 @default.
• W4386523631 hasConceptScore W4386523631C2778341716 @default.
• W4386523631 hasConceptScore W4386523631C2780221984 @default.
• W4386523631 hasConceptScore W4386523631C3018587741 @default.
• W4386523631 hasConceptScore W4386523631C50382708 @default.
• W4386523631 hasConceptScore W4386523631C55520419 @default.
• W4386523631 hasConceptScore W4386523631C71924100 @default.
• W4386523631 hasConceptScore W4386523631C72563966 @default.
• W4386523631 hasLocation W43865236311 @default.
• W4386523631 hasLocation W43865236312 @default.
• W4386523631 hasOpenAccess W4386523631 @default.
• W4386523631 hasPrimaryLocation W43865236311 @default.
• W4386523631 hasRelatedWork W2340104373 @default.
• W4386523631 hasRelatedWork W2990952933 @default.
• W4386523631 hasRelatedWork W3008387124 @default.
• W4386523631 hasRelatedWork W3046994477 @default.
• W4386523631 hasRelatedWork W3092981400 @default.
• W4386523631 hasRelatedWork W3141809981 @default.
• W4386523631 hasRelatedWork W4285544754 @default.

• next