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- W4386524843 endingPage "e3002268" @default.
- W4386524843 startingPage "e3002268" @default.
- W4386524843 abstract "The management of future pandemic risk requires a better understanding of the mechanisms that determine the virulence of emerging zoonotic viruses. Meta-analyses suggest that the virulence of emerging zoonoses is correlated with but not completely predictable from reservoir host phylogeny, indicating that specific characteristics of reservoir host immunology and life history may drive the evolution of viral traits responsible for cross-species virulence. In particular, bats host viruses that cause higher case fatality rates upon spillover to humans than those derived from any other mammal, a phenomenon that cannot be explained by phylogenetic distance alone. In order to disentangle the fundamental drivers of these patterns, we develop a nested modeling framework that highlights mechanisms that underpin the evolution of viral traits in reservoir hosts that cause virulence following cross-species emergence. We apply this framework to generate virulence predictions for viral zoonoses derived from diverse mammalian reservoirs, recapturing trends in virus-induced human mortality rates reported in the literature. Notably, our work offers a mechanistic hypothesis to explain the extreme virulence of bat-borne zoonoses and, more generally, demonstrates how key differences in reservoir host longevity, viral tolerance, and constitutive immunity impact the evolution of viral traits that cause virulence following spillover to humans. Our theoretical framework offers a series of testable questions and predictions designed to stimulate future work comparing cross-species virulence evolution in zoonotic viruses derived from diverse mammalian hosts." @default.
- W4386524843 created "2023-09-08" @default.
- W4386524843 creator A5010580342 @default.
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- W4386524843 creator A5035603577 @default.
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- W4386524843 date "2023-09-07" @default.
- W4386524843 modified "2023-10-02" @default.
- W4386524843 title "Reservoir host immunology and life history shape virulence evolution in zoonotic viruses" @default.
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- W4386524843 doi "https://doi.org/10.1371/journal.pbio.3002268" @default.
- W4386524843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37676899" @default.
- W4386524843 hasPublicationYear "2023" @default.
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