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• W4386529144 abstract "Objectives Fecal microbiota transplantation (FMT) has been recommended for the treatment of recurrent Clostridioides difficile infection (CDI). We aimed to evaluate the therapeutic efficacy and safety of washed microbiota transplantation (WMT), a new method of FMT, for CDI across various medical settings. Methods This multicenter real‐world cohort study included CDI patients undergoing WMT. The primary outcome was the clinical cure rate of CDI within 8 weeks after WMT. Secondary outcomes included the CDI recurrence rate and reduction in total abdominal symptom score (TASS) during the follow‐up period. Adverse events related to WMT were recorded. Results Altogether 90.7% (49/54) of CDI patients achieved clinical cure after treated with WMT. The cure rate was 83.3% for cases with severe and complicated CDI (ScCDI) (n = 30) and 100% for non‐ScCDI cases (n = 24) ( P = 0.059). No difference was observed in the clinical cure rate between patients with first and recurrent CDI (91.9% vs 88.2%, P = 0.645). One week post‐WMT, TASS showed a remarkable decrease compared to that at baseline ( P < 0.001). Totally, 8.2% (4/49) of patients suffered CDI recurrence during the follow‐up period. A WHO performance score of 4, age ≥65 years, higher TASS score, and higher Charlson comorbidity index score were potential risk factors for efficacy ( P = 0.018, 0.03, 0.01, 0.034, respectively). Four (3.8%) transient adverse events related to WMT were observed. Conclusions This study emphasizes the attractive value of WMT for CDI. Early WMT may be recommended for CDI, especially for those in serious condition or with complex comorbidities. Trial registration ClinicalTrials.gov , no. NCT03895593 (registered on 27 March 2019)." @default.
• W4386529144 created "2023-09-09" @default.
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• W4386529144 date "2023-10-05" @default.
• W4386529144 modified "2023-10-18" @default.
• W4386529144 title "Washed microbiota transplantation for <i>Clostridioides difficile</i> infection: a national multi‐center real‐world study" @default.
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• W4386529144 doi "https://doi.org/10.1111/1751-2980.13227" @default.
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