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• W4386529511 abstract "Management of higher-risk myelodysplastic syndromes (HR-MDS) is challenging in the real world. We studied 200 patients with HR-MDS within a large US community hospital network. We describe the clinical presentation, patient-related factors, prognostic characteristics, treatment patterns, clinical outcomes and resource utilization. Patients with HR-MDS, treated in our community setting, were elderly (median age 76 years) with a high comorbidity burden. First-line therapy was hypomethylating agent (HMA) monotherapy (20%), lenalidomide (2%), and venetoclax (2%), while the rest were treated with supportive care. Sixty-one percent of the 200, were subsequently hospitalized within 6 months of initial diagnosis. Overall survival was 11.8 months. Curative transplantation was infrequent, HMA-based therapy was underutilized, responses were not durable, most patients became transfusion-dependent or transformed to AML, and resource utilization was substantial and was highly correlated with total in-hospital days. There is a clear unmet need for tolerable treatments that can produce durable remissions in this population." @default.
• W4386529511 created "2023-09-09" @default.
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• W4386529511 date "2023-09-07" @default.
• W4386529511 modified "2023-10-16" @default.
• W4386529511 title "Treatment patterns, resource utilization and clinical outcomes in patients with higher risk myelodysplastic syndromes (MDS) in United States community practices" @default.
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• W4386529511 doi "https://doi.org/10.1080/10428194.2023.2254429" @default.
• W4386529511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37680012" @default.
• W4386529511 hasPublicationYear "2023" @default.
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