Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386530629> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4386530629 abstract "INTRODUCTION: To investigate the roles of the extracellular vesicles (EVs) secreted from the bone marrow-mesenchymal stem cell (BMSCs) and miR-27-3p (highly expressed in BMSC EVs) in hepatic ischemia-reperfusion injury (HIRI), we constructed an HIRI mouse model and pretreated it with an injection of BMSC-EVs or control normal PBS into the abdominal cavity. METHOD: Compared with the HIRI group, HIRI mice preinjected with BMSC-EVs had significantly decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and alleviated liver necrosis (P<0.05). The miRNA sequencing of BMSC exosomes revealed that miR-27-3p, which is related to I/R injury, was enriched in the exosomes. We then pretreated the HIRI mouse model with an injection of agomir-miR-27-3p and agomir-NC into the abdominal cavity. However, compared with HIRI+NC mice, HIRI+miR-27 mice had significantly increased ALT and AST levels, aggravated liver necrosis, and increased apoptosis-related protein expression (P<0.05). RESULT: The proliferation and apoptosis of AML-12 cells transfected with miR-27-3p were significantly higher than the proliferation and apoptosis of AML-12 cells in the mimic NC group (P<0.01) after hypoxia induction. SMAD4 was proven to be a miR-27-3p target gene. Furthermore, compared to HIRI+NC mice, HIRI+miR-27 mice displayed markedly reduced SMAD4 expression. CONCLUSION: Our findings revealed the role and mechanism of miR-27-3p in HIRI and provide novel insights for the prevention and treatment of HIRI; for example, EVs derived from BMSCs transfected with antimiR-27 might demonstrate better protection against HIRI." @default.
- W4386530629 created "2023-09-09" @default.
- W4386530629 creator A5000593612 @default.
- W4386530629 creator A5008411660 @default.
- W4386530629 creator A5023289032 @default.
- W4386530629 creator A5024972824 @default.
- W4386530629 creator A5034981144 @default.
- W4386530629 creator A5059256450 @default.
- W4386530629 creator A5064832181 @default.
- W4386530629 creator A5067516145 @default.
- W4386530629 creator A5069479723 @default.
- W4386530629 date "2023-09-01" @default.
- W4386530629 modified "2023-10-06" @default.
- W4386530629 title "Bone marrow mesenchymal stem cell extracellular vesicle-derived miR-27b-3p activates the Wnt/β-catenin pathway by targeting SMAD4 and aggravates hepatic ischemia–reperfusion injury" @default.
- W4386530629 doi "https://doi.org/10.2174/1574888x19666230901140628" @default.
- W4386530629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37680161" @default.
- W4386530629 hasPublicationYear "2023" @default.
- W4386530629 type Work @default.
- W4386530629 citedByCount "0" @default.
- W4386530629 crossrefType "journal-article" @default.
- W4386530629 hasAuthorship W4386530629A5000593612 @default.
- W4386530629 hasAuthorship W4386530629A5008411660 @default.
- W4386530629 hasAuthorship W4386530629A5023289032 @default.
- W4386530629 hasAuthorship W4386530629A5024972824 @default.
- W4386530629 hasAuthorship W4386530629A5034981144 @default.
- W4386530629 hasAuthorship W4386530629A5059256450 @default.
- W4386530629 hasAuthorship W4386530629A5064832181 @default.
- W4386530629 hasAuthorship W4386530629A5067516145 @default.
- W4386530629 hasAuthorship W4386530629A5069479723 @default.
- W4386530629 hasConcept C137620995 @default.
- W4386530629 hasConcept C153911025 @default.
- W4386530629 hasConcept C16685009 @default.
- W4386530629 hasConcept C185592680 @default.
- W4386530629 hasConcept C190283241 @default.
- W4386530629 hasConcept C198826908 @default.
- W4386530629 hasConcept C28328180 @default.
- W4386530629 hasConcept C55493867 @default.
- W4386530629 hasConcept C62478195 @default.
- W4386530629 hasConcept C71924100 @default.
- W4386530629 hasConcept C86803240 @default.
- W4386530629 hasConcept C95444343 @default.
- W4386530629 hasConceptScore W4386530629C137620995 @default.
- W4386530629 hasConceptScore W4386530629C153911025 @default.
- W4386530629 hasConceptScore W4386530629C16685009 @default.
- W4386530629 hasConceptScore W4386530629C185592680 @default.
- W4386530629 hasConceptScore W4386530629C190283241 @default.
- W4386530629 hasConceptScore W4386530629C198826908 @default.
- W4386530629 hasConceptScore W4386530629C28328180 @default.
- W4386530629 hasConceptScore W4386530629C55493867 @default.
- W4386530629 hasConceptScore W4386530629C62478195 @default.
- W4386530629 hasConceptScore W4386530629C71924100 @default.
- W4386530629 hasConceptScore W4386530629C86803240 @default.
- W4386530629 hasConceptScore W4386530629C95444343 @default.
- W4386530629 hasLocation W43865306291 @default.
- W4386530629 hasLocation W43865306292 @default.
- W4386530629 hasOpenAccess W4386530629 @default.
- W4386530629 hasPrimaryLocation W43865306291 @default.
- W4386530629 hasRelatedWork W1522190715 @default.
- W4386530629 hasRelatedWork W1759652240 @default.
- W4386530629 hasRelatedWork W2003337073 @default.
- W4386530629 hasRelatedWork W2008014566 @default.
- W4386530629 hasRelatedWork W2123037811 @default.
- W4386530629 hasRelatedWork W2320606495 @default.
- W4386530629 hasRelatedWork W2748952813 @default.
- W4386530629 hasRelatedWork W2899084033 @default.
- W4386530629 hasRelatedWork W3120507315 @default.
- W4386530629 hasRelatedWork W3123261447 @default.
- W4386530629 hasVolume "19" @default.
- W4386530629 isParatext "false" @default.
- W4386530629 isRetracted "false" @default.
- W4386530629 workType "article" @default.