FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386531077> ?p ?o ?g. }

• W4386531077 abstract "Abstract XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid spermatozoa. A leading cause of XY missegregation in mammals is the lack of formation of double-strand breaks (DSBs) in the pseudoautosomal region (PAR), a defect that may occur in mice due to faulty expression of Spo11 splice isoforms. Using a knock-in (ki) mouse that expresses only the single Spo11β splice isoform, here we demonstrate that by varying the genetic background of mice, the length of chromatin loops extending from the PAR axis and the XY recombination proficiency varies. In spermatocytes of C57 Spo11βki/− mice, in which loops are relatively short, recombination/synapsis between XY is fairly normal. In contrast, in cells of C57/129 Spo11βki/− males where PAR loops are relatively long, formation of DSBs in the PAR (more frequently the Y-PAR) and XY synapsis fails at a high rate, and mice produce sperm with sex-chromosomal aneuploidy. However, if the entire set of Spo11 splicing isoforms is expressed by a wild type allele in the C57/129 background, XY recombination and synapsis is recovered. By generating a Spo11αki mouse model, we prove that concomitant expression of SPO11β and SPO11α isoforms, boosts DSB formation in the PAR. Based on these findings, we propose that SPO11 splice isoforms cooperate functionally in promoting recombination in the PAR, constraining XY asynapsis defects that may arise due to differences in the conformation of the PAR between mouse strains." @default.
• W4386531077 created "2023-09-09" @default.
• W4386531077 creator A5004612916 @default.
• W4386531077 creator A5022220286 @default.
• W4386531077 creator A5030336076 @default.
• W4386531077 creator A5032372154 @default.
• W4386531077 creator A5067478179 @default.
• W4386531077 creator A5072559544 @default.
• W4386531077 creator A5090776655 @default.
• W4386531077 creator A5092620873 @default.
• W4386531077 date "2023-09-08" @default.
• W4386531077 modified "2023-10-13" @default.
• W4386531077 title "The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination" @default.
• W4386531077 cites W1606401780 @default.
• W4386531077 cites W1876047377 @default.
• W4386531077 cites W1902427536 @default.
• W4386531077 cites W1928207406 @default.
• W4386531077 cites W1966608028 @default.
• W4386531077 cites W1981372238 @default.
• W4386531077 cites W1986458631 @default.
• W4386531077 cites W1987995349 @default.
• W4386531077 cites W1989788017 @default.
• W4386531077 cites W1990699200 @default.
• W4386531077 cites W1997957204 @default.
• W4386531077 cites W2002454928 @default.
• W4386531077 cites W2011867412 @default.
• W4386531077 cites W2016505307 @default.
• W4386531077 cites W2023488322 @default.
• W4386531077 cites W2034252391 @default.
• W4386531077 cites W2043641551 @default.
• W4386531077 cites W2054305990 @default.
• W4386531077 cites W2056299136 @default.
• W4386531077 cites W2060234119 @default.
• W4386531077 cites W2067338267 @default.
• W4386531077 cites W2069829573 @default.
• W4386531077 cites W2070744469 @default.
• W4386531077 cites W2073365040 @default.
• W4386531077 cites W2093040444 @default.
• W4386531077 cites W2106011489 @default.
• W4386531077 cites W2110468645 @default.
• W4386531077 cites W2118289533 @default.
• W4386531077 cites W2125229799 @default.
• W4386531077 cites W2126187754 @default.
• W4386531077 cites W2127602493 @default.
• W4386531077 cites W2133293952 @default.
• W4386531077 cites W2133492775 @default.
• W4386531077 cites W2136275081 @default.
• W4386531077 cites W2138919235 @default.
• W4386531077 cites W2148821835 @default.
• W4386531077 cites W2166223300 @default.
• W4386531077 cites W2275186331 @default.
• W4386531077 cites W2302254328 @default.
• W4386531077 cites W2401043180 @default.
• W4386531077 cites W2406347364 @default.
• W4386531077 cites W2529866986 @default.
• W4386531077 cites W2560471559 @default.
• W4386531077 cites W2616339563 @default.
• W4386531077 cites W2785428782 @default.
• W4386531077 cites W2892300792 @default.
• W4386531077 cites W2937544611 @default.
• W4386531077 cites W2952406177 @default.
• W4386531077 cites W3030424063 @default.
• W4386531077 cites W3032720955 @default.
• W4386531077 cites W4309235947 @default.
• W4386531077 cites W4360976683 @default.
• W4386531077 doi "https://doi.org/10.1007/s00018-023-04912-7" @default.
• W4386531077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37682311" @default.
• W4386531077 hasPublicationYear "2023" @default.
• W4386531077 type Work @default.
• W4386531077 citedByCount "0" @default.
• W4386531077 crossrefType "journal-article" @default.
• W4386531077 hasAuthorship W4386531077A5004612916 @default.
• W4386531077 hasAuthorship W4386531077A5022220286 @default.
• W4386531077 hasAuthorship W4386531077A5030336076 @default.
• W4386531077 hasAuthorship W4386531077A5032372154 @default.
• W4386531077 hasAuthorship W4386531077A5067478179 @default.
• W4386531077 hasAuthorship W4386531077A5072559544 @default.
• W4386531077 hasAuthorship W4386531077A5090776655 @default.
• W4386531077 hasAuthorship W4386531077A5092620873 @default.
• W4386531077 hasBestOaLocation W43865310771 @default.
• W4386531077 hasConcept C104317684 @default.
• W4386531077 hasConcept C148196450 @default.
• W4386531077 hasConcept C153911025 @default.
• W4386531077 hasConcept C156695909 @default.
• W4386531077 hasConcept C169836425 @default.
• W4386531077 hasConcept C201437064 @default.
• W4386531077 hasConcept C53345823 @default.
• W4386531077 hasConcept C54059333 @default.
• W4386531077 hasConcept C54355233 @default.
• W4386531077 hasConcept C86803240 @default.
• W4386531077 hasConcept C95444343 @default.
• W4386531077 hasConceptScore W4386531077C104317684 @default.
• W4386531077 hasConceptScore W4386531077C148196450 @default.
• W4386531077 hasConceptScore W4386531077C153911025 @default.
• W4386531077 hasConceptScore W4386531077C156695909 @default.
• W4386531077 hasConceptScore W4386531077C169836425 @default.
• W4386531077 hasConceptScore W4386531077C201437064 @default.
• W4386531077 hasConceptScore W4386531077C53345823 @default.
• W4386531077 hasConceptScore W4386531077C54059333 @default.
• W4386531077 hasConceptScore W4386531077C54355233 @default.

• next