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- W4386531310 abstract "Milk fat globule epidermal growth factor VIII (MFG-E8) and whey protein have emerged as promising bionutrient supplements for enhancing skeletal muscle mass and function. In the present study, aging-related sarcopenia rat model was employed to elucidate the effects of the combined administration of MFG-E8 and whey protein on the catabolism and anabolism of gastrocnemius protein. Combined intervention led to notable enhancements in the anti-oxidative stress status and mitochondrial biogenesis capacity of gastrocnemius muscle fibers in the aging rats, concomitant with a significant inhibition of lipid accumulation. Moreover, the synergistic effect of MFG-E8 and whey protein was found to exert modulatory effects on key signaling pathways, including PI3K/Akt/PGC-1α pathway and MAPK/ERK signaling pathways in the gastrocnemius muscle of the aging rats. Specifically, this combined intervention was observed to promote mitochondrial biogenesis and regulate the expression of protein anabolism and catabolism-related regulators, thereby facilitating the alleviation of mitochondrial oxidative stress and enhancing biogenesis in gastrocnemius tissues. The findings of our study provide compelling evidence for the potential of MFG-E8 as a promising dietary supplement with anti-sarcopenic properties to ameliorate muscle protein metabolism disorders and mitigate mitochondrial-mediated myoblast apoptosis induced by oxidative stress." @default.
- W4386531310 created "2023-09-09" @default.
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- W4386531310 date "2023-09-01" @default.
- W4386531310 modified "2023-10-16" @default.
- W4386531310 title "Synergistic effects of MFG-E8 and whey protein on mitigating D-galactose-induced sarcopenia through PI3K/AKT/PGC-1α and MAPK/ERK signaling pathways" @default.
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- W4386531310 doi "https://doi.org/10.3168/jds.2023-23637" @default.
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