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• W4386532019 abstract "Abstract Background: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding is crucial for ensuring safe and reliable procedures. ESD using the Spray Coagulation Mode (SCM-ESD) has been developed to control bleeding more effectively than ESD using the conventional Forced Coagulation mode (FCM-ESD). This study aims to compare the hemostatic efficacies of SCM-ESD and FCM-ESD. Methods: This multicenter, prospective, parallel, randomized, open-label superiority trial will be conducted in five Japanese institutions. Patients with a preoperative diagnosis of intramucosal EGC will be randomized to undergo either SCM-ESD or FCM-ESD. The primary outcome measure is the completion of ESD with an electrosurgical knife alone, without the use of hemostatic forceps. Secondary outcomes include the number and duration of hemostasis using hemostatic forceps, procedure time, curability, and safety. A total of 130 patients will be enrolled in this study. Discussion: This trial will provide evidence on the hemostatic efficacy of SCM-ESD compared with FCM-ESD in patients with intramucosal EGN, potentially improving the safety and reliability of ESD procedures. Trial Registration: The trial has been registered at the University Hospital Medical Information Network Clinical Trials Registration (UMIN-CTR) as UMIN000040518." @default.
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• W4386532019 date "2023-09-09" @default.
• W4386532019 modified "2023-10-14" @default.
• W4386532019 title "Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: A study protocol for multicenter randomized controlled trial (Spray-G trial)" @default.
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• W4386532019 doi "https://doi.org/10.21203/rs.3.rs-3130276/v1" @default.
• W4386532019 hasPublicationYear "2023" @default.
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