Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386537654> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4386537654 endingPage "ii119" @default.
- W4386537654 startingPage "ii119" @default.
- W4386537654 abstract "Abstract BACKGROUND Prolyl oligopeptidase (PREP) is a serine protease that hydrolyzes biologically active oligopeptides on their carboxyl side. PREP has been connected with multiple physiological and pathological conditions. Moreover, increased PREP activities have been found in tumors, although its involvement in the modulation of cancer mechanism is still unclear. Thus, the identification of PREP and clarification of its clinical significance are important for improving the diagnosis and treatment of brain tumors. The purpose of this study was to analyze the expression of PREP and its diagnostic and prognostic value in patients with Glioblastoma (GBM). Materials and METHODS In this study, GBM patients and controls were enrolled and clinical data and PREP expression, from serum and biopsies, were collected. The relationships between PREP, Protein phosphatase 2A (PP2A), STAT3 and Transforming growth factor-β (TGF- β) were also analyzed from clinical data. RESULTS Our study found that PREP was significantly upregulated in the serum samples and in biopsy from GBM patients compared with controls. This upregulation was negatively correlated with survival, but significantly correlated with age and Mindbomb Homolog-1 Index (MIB1). Also, PREP expression was inversely correlated with tumor suppressor PP2A in biopsy from GBM patients, while PREP protein levels resulted to be positively correlated with STAT3 and TGF-β protein expression. CONCLUSION s: The detection of PREP in serum and biopsies have the potential to serve as diagnostic and prognostic biomarker in GBM patient. The findings may provide diagnostic and therapeutic target for GBM." @default.
- W4386537654 created "2023-09-09" @default.
- W4386537654 creator A5007489715 @default.
- W4386537654 creator A5012341521 @default.
- W4386537654 creator A5028276792 @default.
- W4386537654 creator A5034178951 @default.
- W4386537654 creator A5044918169 @default.
- W4386537654 creator A5048364314 @default.
- W4386537654 creator A5063288145 @default.
- W4386537654 creator A5065961339 @default.
- W4386537654 creator A5073045089 @default.
- W4386537654 creator A5076323717 @default.
- W4386537654 date "2023-09-01" @default.
- W4386537654 modified "2023-10-16" @default.
- W4386537654 title "P17.12.B FEASIBILITY OF PROLYL OLIGOPEPTIDASE (PREP) AS TUMOR BIOMARKER IN GLIOBLASTOMA PATIENTS: A PILOT STUDY" @default.
- W4386537654 doi "https://doi.org/10.1093/neuonc/noad137.402" @default.
- W4386537654 hasPublicationYear "2023" @default.
- W4386537654 type Work @default.
- W4386537654 citedByCount "0" @default.
- W4386537654 crossrefType "journal-article" @default.
- W4386537654 hasAuthorship W4386537654A5007489715 @default.
- W4386537654 hasAuthorship W4386537654A5012341521 @default.
- W4386537654 hasAuthorship W4386537654A5028276792 @default.
- W4386537654 hasAuthorship W4386537654A5034178951 @default.
- W4386537654 hasAuthorship W4386537654A5044918169 @default.
- W4386537654 hasAuthorship W4386537654A5048364314 @default.
- W4386537654 hasAuthorship W4386537654A5063288145 @default.
- W4386537654 hasAuthorship W4386537654A5065961339 @default.
- W4386537654 hasAuthorship W4386537654A5073045089 @default.
- W4386537654 hasAuthorship W4386537654A5076323717 @default.
- W4386537654 hasConcept C104317684 @default.
- W4386537654 hasConcept C121608353 @default.
- W4386537654 hasConcept C126322002 @default.
- W4386537654 hasConcept C127561419 @default.
- W4386537654 hasConcept C142724271 @default.
- W4386537654 hasConcept C143998085 @default.
- W4386537654 hasConcept C181199279 @default.
- W4386537654 hasConcept C2775934546 @default.
- W4386537654 hasConcept C2780043585 @default.
- W4386537654 hasConcept C2781197716 @default.
- W4386537654 hasConcept C502942594 @default.
- W4386537654 hasConcept C55493867 @default.
- W4386537654 hasConcept C63363279 @default.
- W4386537654 hasConcept C71924100 @default.
- W4386537654 hasConcept C86803240 @default.
- W4386537654 hasConceptScore W4386537654C104317684 @default.
- W4386537654 hasConceptScore W4386537654C121608353 @default.
- W4386537654 hasConceptScore W4386537654C126322002 @default.
- W4386537654 hasConceptScore W4386537654C127561419 @default.
- W4386537654 hasConceptScore W4386537654C142724271 @default.
- W4386537654 hasConceptScore W4386537654C143998085 @default.
- W4386537654 hasConceptScore W4386537654C181199279 @default.
- W4386537654 hasConceptScore W4386537654C2775934546 @default.
- W4386537654 hasConceptScore W4386537654C2780043585 @default.
- W4386537654 hasConceptScore W4386537654C2781197716 @default.
- W4386537654 hasConceptScore W4386537654C502942594 @default.
- W4386537654 hasConceptScore W4386537654C55493867 @default.
- W4386537654 hasConceptScore W4386537654C63363279 @default.
- W4386537654 hasConceptScore W4386537654C71924100 @default.
- W4386537654 hasConceptScore W4386537654C86803240 @default.
- W4386537654 hasIssue "Supplement_2" @default.
- W4386537654 hasLocation W43865376541 @default.
- W4386537654 hasOpenAccess W4386537654 @default.
- W4386537654 hasPrimaryLocation W43865376541 @default.
- W4386537654 hasRelatedWork W2020449916 @default.
- W4386537654 hasRelatedWork W2024344351 @default.
- W4386537654 hasRelatedWork W2064121576 @default.
- W4386537654 hasRelatedWork W2346343701 @default.
- W4386537654 hasRelatedWork W2463357763 @default.
- W4386537654 hasRelatedWork W2539555867 @default.
- W4386537654 hasRelatedWork W3049714071 @default.
- W4386537654 hasRelatedWork W3135541191 @default.
- W4386537654 hasRelatedWork W4224992682 @default.
- W4386537654 hasRelatedWork W4311271618 @default.
- W4386537654 hasVolume "25" @default.
- W4386537654 isParatext "false" @default.
- W4386537654 isRetracted "false" @default.
- W4386537654 workType "article" @default.