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• W4386540975 abstract "Avocado fruit pulp (Persea americana) of the Booth 7 cultivar was explored for its bioactive compounds. Polyhydroxylated fatty alcohols, also known as polyols or acetogenins, were obtained after chromatographic separation of a crude pulp extract of P. americana. Five polyols 1–5, including known ones, avocadyne (1), avocadene (2), avocadenol D (4), and avoenin (5), together with a new natural product, namely, avocadinin (3), were isolated from avocado fruit pulp. Some polyhydroxylated fatty alcohols exhibited virucidal and antiviral activities. Avocadinin (3), avocadenol D (4), and avoenin (5) exhibited virucidal activity against a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surrogate, with EC50 values of 2.30, 2.69, and 1.69 μM, respectively. For antiviral activity, avocadenol D (4) displayed the activity with an EC50 value of 5.82 μM, while avocadinin (3) and avoenin (5) exhibited less antiviral activity with respective EC50 values of 11.99 and 14.32 μM." @default.
• W4386540975 created "2023-09-09" @default.
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• W4386540975 date "2023-09-08" @default.
• W4386540975 modified "2023-10-16" @default.
• W4386540975 title "Virucidal and Antiviral Polyhydroxylated Fatty Alcohols in Avocado Fruit Pulp (<i>Persea americana</i>) of Booth 7 Cultivar^¶" @default.
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• W4386540975 doi "https://doi.org/10.1021/acsfoodscitech.3c00326" @default.
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