FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386542334> ?p ?o ?g. }

• W4386542334 abstract "Abstract Inositol depletion is a hypothesized mechanism of action of mood stabilization drugs used in the treatment of bipolar disorder. It was previously reported that the mood stabilizer valproate (VPA) increased phosphorylation of myo -inositol-3-phosphate synthases (MIPS), the rate limiting enzyme of inositol synthesis. Phosphosites were identified and examination of site-directed mutants suggested that phosphorylation leads to decreased enzymatic activity. In this study, we examined the extent of MIPS phosphorylation in response to VPA and used two interaction screens to identify protein kinases that interact with MIPS. Using an epitope tagged MIPS construct, we determined the fraction of phosphorylated MIPS to be very low (less than 2% of total), and we could not detect phosphorylation of untagged MIPS in response to VPA. In vitro analyses of phosphorylation revealed that putative protein kinases, PKC and CKII, have low specificity toward MIPS. These findings suggest that VPA likely depletes inositol via a mechanism other than MIPS phosphorylation. Consistent with this, mRNA levels of the MIPS-encoding gene INO1 and MIPS protein levels were significantly reduced during the mid-log growth phase in response to VPA treatment. These findings suggest that the mechanism whereby VPA causes inositol depletion is by reducing expression of the rate-limiting enzyme MIPS." @default.
• W4386542334 created "2023-09-09" @default.
• W4386542334 creator A5000440766 @default.
• W4386542334 creator A5013405117 @default.
• W4386542334 creator A5054066674 @default.
• W4386542334 creator A5088701006 @default.
• W4386542334 date "2023-09-08" @default.
• W4386542334 modified "2023-10-14" @default.
• W4386542334 title "Valproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase" @default.
• W4386542334 cites W1508683498 @default.
• W4386542334 cites W1593180325 @default.
• W4386542334 cites W1854727002 @default.
• W4386542334 cites W1889236699 @default.
• W4386542334 cites W1927894522 @default.
• W4386542334 cites W1965437539 @default.
• W4386542334 cites W1990899386 @default.
• W4386542334 cites W1997093700 @default.
• W4386542334 cites W1997309294 @default.
• W4386542334 cites W2001184915 @default.
• W4386542334 cites W2004596644 @default.
• W4386542334 cites W2010348734 @default.
• W4386542334 cites W2022870456 @default.
• W4386542334 cites W2025595506 @default.
• W4386542334 cites W2065684604 @default.
• W4386542334 cites W2066860094 @default.
• W4386542334 cites W2074085337 @default.
• W4386542334 cites W2075372825 @default.
• W4386542334 cites W2080348385 @default.
• W4386542334 cites W2080752012 @default.
• W4386542334 cites W2080944633 @default.
• W4386542334 cites W2081049470 @default.
• W4386542334 cites W2083122015 @default.
• W4386542334 cites W2084279854 @default.
• W4386542334 cites W2085037886 @default.
• W4386542334 cites W2091884933 @default.
• W4386542334 cites W2099663521 @default.
• W4386542334 cites W2102651270 @default.
• W4386542334 cites W2102823881 @default.
• W4386542334 cites W2104244040 @default.
• W4386542334 cites W2105355225 @default.
• W4386542334 cites W2123352057 @default.
• W4386542334 cites W2129537329 @default.
• W4386542334 cites W2152261949 @default.
• W4386542334 cites W2164078051 @default.
• W4386542334 cites W2165395435 @default.
• W4386542334 cites W2295732522 @default.
• W4386542334 cites W2304846645 @default.
• W4386542334 cites W2315751674 @default.
• W4386542334 cites W2342510067 @default.
• W4386542334 cites W2490568614 @default.
• W4386542334 cites W2745427183 @default.
• W4386542334 cites W2761573588 @default.
• W4386542334 cites W2761938632 @default.
• W4386542334 cites W2896608315 @default.
• W4386542334 cites W2907742050 @default.
• W4386542334 cites W2943036834 @default.
• W4386542334 cites W2950210999 @default.
• W4386542334 cites W2962687384 @default.
• W4386542334 cites W2982311673 @default.
• W4386542334 cites W3095522980 @default.
• W4386542334 cites W3195347193 @default.
• W4386542334 cites W3200609087 @default.
• W4386542334 cites W4221100616 @default.
• W4386542334 cites W4224313704 @default.
• W4386542334 cites W4283750312 @default.
• W4386542334 cites W4291398697 @default.
• W4386542334 cites W4296653612 @default.
• W4386542334 doi "https://doi.org/10.1038/s41598-023-41936-2" @default.
• W4386542334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37684289" @default.
• W4386542334 hasPublicationYear "2023" @default.
• W4386542334 type Work @default.
• W4386542334 citedByCount "0" @default.
• W4386542334 crossrefType "journal-article" @default.
• W4386542334 hasAuthorship W4386542334A5000440766 @default.
• W4386542334 hasAuthorship W4386542334A5013405117 @default.
• W4386542334 hasAuthorship W4386542334A5054066674 @default.
• W4386542334 hasAuthorship W4386542334A5088701006 @default.
• W4386542334 hasBestOaLocation W43865423341 @default.
• W4386542334 hasConcept C11960822 @default.
• W4386542334 hasConcept C170493617 @default.
• W4386542334 hasConcept C181199279 @default.
• W4386542334 hasConcept C184235292 @default.
• W4386542334 hasConcept C185592680 @default.
• W4386542334 hasConcept C195794163 @default.
• W4386542334 hasConcept C202751555 @default.
• W4386542334 hasConcept C2776120743 @default.
• W4386542334 hasConcept C2777427919 @default.
• W4386542334 hasConcept C2778618036 @default.
• W4386542334 hasConcept C55493867 @default.
• W4386542334 hasConcept C86803240 @default.
• W4386542334 hasConcept C87325107 @default.
• W4386542334 hasConcept C97029542 @default.
• W4386542334 hasConcept C98274493 @default.
• W4386542334 hasConceptScore W4386542334C11960822 @default.
• W4386542334 hasConceptScore W4386542334C170493617 @default.
• W4386542334 hasConceptScore W4386542334C181199279 @default.
• W4386542334 hasConceptScore W4386542334C184235292 @default.
• W4386542334 hasConceptScore W4386542334C185592680 @default.
• W4386542334 hasConceptScore W4386542334C195794163 @default.
• W4386542334 hasConceptScore W4386542334C202751555 @default.

• next