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- W4386542874 abstract "Chikungunya virus (CHIKV) is transmitted by the bite of infected mosquitoes and can cause significant pathogenicity in humans. Moreover, its importance has increased in the Americas since 2013. The primary vectors for viral delivery are the mosquito species Aedes aegypti and Aedes albopictus. Several factors, including host genetic variations and immune response against CHIKV, influence the outcomes of Chikungunya disease. This work aimed to gather information about different single nucleotide polymorphisms (SNPs) in genes that influence the host immune response during an infection by CHIKV. The viral characteristics, disease epidemiology, clinical manifestations, and immune response against CHIKV are also addressed. The main immune molecules related to this arboviral disease elucidated in this review are TLR3/7/8, DC-SIGN, HLA-DRB1/HLA-DQB1, TNF, IL1RN, OAS2/3, and CRP. Advances in knowledge about the genetic basis of the immune response during CHIKV infection are essential for expanding the understanding of disease pathophysiology, providing new genetic markers for prognosis, and identifying molecular targets for the development of new drug treatments." @default.
- W4386542874 created "2023-09-09" @default.
- W4386542874 creator A5030740561 @default.
- W4386542874 creator A5056228088 @default.
- W4386542874 creator A5090752315 @default.
- W4386542874 date "2023-01-01" @default.
- W4386542874 modified "2023-10-18" @default.
- W4386542874 title "Influence of host genetic polymorphisms involved in immune response and their role in the development of Chikungunya disease: a review" @default.
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- W4386542874 doi "https://doi.org/10.1590/1414-431x2023e12557" @default.
- W4386542874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37703107" @default.
- W4386542874 hasPublicationYear "2023" @default.
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