Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386543809> ?p ?o ?g. }
- W4386543809 abstract "Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques followed by intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. An unrestrained immune response by microglia, the resident cells of the central nervous system (CNS), leads to neuroinflammation which can amplify AD pathology. AD pathology is also driven by metabolic dysfunction with strong correlations between dementia and metabolic disorders such as diabetes, hypercholesterolemia, and hypertriglyceridemia. Since elevated cholesterol and triglyceride levels appear to be a major risk factor for developing AD, we investigated the lipid metabolism transcriptome in an AD versus non-AD state using RNA-sequencing (RNA-seq) and microarray datasets from N9 cells and murine microglia. We identified 52 differentially expressed genes (DEG) linked to lipid metabolism in LPS-stimulated N9 microglia versus unstimulated control cells using RNA-seq, 86 lipid metabolism DEG in 5XFAD versus wild-type mice by microarray, with 16 DEG common between both datasets. Functional enrichment and network analyses identified several biological processes and molecular functions, such as cholesterol homeostasis, insulin signaling, and triglyceride metabolism. Furthermore, therapeutic drugs targeting lipid metabolism DEG found in our study were identified. Focusing on drugs that target genes associated with lipid metabolism and neuroinflammation could provide new targets for AD drug development." @default.
- W4386543809 created "2023-09-09" @default.
- W4386543809 creator A5016691718 @default.
- W4386543809 creator A5048605590 @default.
- W4386543809 date "2023-09-08" @default.
- W4386543809 modified "2023-10-14" @default.
- W4386543809 title "Lipid metabolism transcriptomics of murine microglia in Alzheimer’s disease and neuroinflammation" @default.
- W4386543809 cites W1530780272 @default.
- W4386543809 cites W1560020441 @default.
- W4386543809 cites W1586863418 @default.
- W4386543809 cites W1634034367 @default.
- W4386543809 cites W1841850981 @default.
- W4386543809 cites W1976168084 @default.
- W4386543809 cites W1977099733 @default.
- W4386543809 cites W1982789996 @default.
- W4386543809 cites W1991882271 @default.
- W4386543809 cites W1993976394 @default.
- W4386543809 cites W2004349171 @default.
- W4386543809 cites W2011041653 @default.
- W4386543809 cites W2012221575 @default.
- W4386543809 cites W2031687154 @default.
- W4386543809 cites W2047895583 @default.
- W4386543809 cites W2070126411 @default.
- W4386543809 cites W2079938040 @default.
- W4386543809 cites W2081262717 @default.
- W4386543809 cites W2091043188 @default.
- W4386543809 cites W2096499083 @default.
- W4386543809 cites W2099040516 @default.
- W4386543809 cites W2108326377 @default.
- W4386543809 cites W2115738813 @default.
- W4386543809 cites W2117842413 @default.
- W4386543809 cites W2133465414 @default.
- W4386543809 cites W2143955562 @default.
- W4386543809 cites W2152907424 @default.
- W4386543809 cites W2158008755 @default.
- W4386543809 cites W2158217645 @default.
- W4386543809 cites W2170644095 @default.
- W4386543809 cites W2208143356 @default.
- W4386543809 cites W2268827448 @default.
- W4386543809 cites W2299435740 @default.
- W4386543809 cites W2414913258 @default.
- W4386543809 cites W2588146368 @default.
- W4386543809 cites W2608076792 @default.
- W4386543809 cites W2622807556 @default.
- W4386543809 cites W2731616294 @default.
- W4386543809 cites W2743727231 @default.
- W4386543809 cites W2754890392 @default.
- W4386543809 cites W2769815973 @default.
- W4386543809 cites W2900569176 @default.
- W4386543809 cites W2901436247 @default.
- W4386543809 cites W2950753203 @default.
- W4386543809 cites W2980880709 @default.
- W4386543809 cites W2982594794 @default.
- W4386543809 cites W2998795963 @default.
- W4386543809 cites W3008202901 @default.
- W4386543809 cites W3021410383 @default.
- W4386543809 cites W3025084871 @default.
- W4386543809 cites W3026991975 @default.
- W4386543809 cites W3049289769 @default.
- W4386543809 cites W3087077238 @default.
- W4386543809 cites W3107626709 @default.
- W4386543809 cites W3109942090 @default.
- W4386543809 cites W3111509171 @default.
- W4386543809 cites W3119403831 @default.
- W4386543809 cites W3135128391 @default.
- W4386543809 cites W3149600507 @default.
- W4386543809 cites W3177458716 @default.
- W4386543809 cites W3185184038 @default.
- W4386543809 cites W3196772707 @default.
- W4386543809 cites W4200025346 @default.
- W4386543809 cites W4220844449 @default.
- W4386543809 cites W4220857261 @default.
- W4386543809 cites W4221004617 @default.
- W4386543809 cites W424467158 @default.
- W4386543809 cites W4309466148 @default.
- W4386543809 cites W4315434323 @default.
- W4386543809 cites W4322720275 @default.
- W4386543809 doi "https://doi.org/10.1038/s41598-023-41897-6" @default.
- W4386543809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37684405" @default.
- W4386543809 hasPublicationYear "2023" @default.
- W4386543809 type Work @default.
- W4386543809 citedByCount "0" @default.
- W4386543809 crossrefType "journal-article" @default.
- W4386543809 hasAuthorship W4386543809A5016691718 @default.
- W4386543809 hasAuthorship W4386543809A5048605590 @default.
- W4386543809 hasBestOaLocation W43865438091 @default.
- W4386543809 hasConcept C104317684 @default.
- W4386543809 hasConcept C126322002 @default.
- W4386543809 hasConcept C134018914 @default.
- W4386543809 hasConcept C150194340 @default.
- W4386543809 hasConcept C162317418 @default.
- W4386543809 hasConcept C203014093 @default.
- W4386543809 hasConcept C2776914184 @default.
- W4386543809 hasConcept C2776925932 @default.
- W4386543809 hasConcept C2779134260 @default.
- W4386543809 hasConcept C2779685842 @default.
- W4386543809 hasConcept C2779830541 @default.
- W4386543809 hasConcept C4733338 @default.
- W4386543809 hasConcept C502032728 @default.
- W4386543809 hasConcept C55493867 @default.