FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386545412> ?p ?o ?g. }

• W4386545412 abstract "Radiotherapy is a non-invasive standard treatment for prostate cancer (PC). However, PC develops radio-resistance, highlighting a need for agents to improve radiotherapy response. Canagliflozin, an inhibitor of sodium-glucose co-transporter-2, is approved for use in diabetes and heart failure, but is also shown to inhibit PC growth. However, whether canagliflozin can improve radiotherapy response in PC remains unknown. Here, we show that well-tolerated doses of canagliflozin suppress proliferation and survival of androgen-sensitive and insensitive human PC cells and tumors and sensitize them to radiotherapy. Canagliflozin blocks mitochondrial respiration, promotes AMPK activity, inhibits the MAPK and mTOR-p70S6k/4EBP1 pathways, activates cell cycle checkpoints, and inhibits proliferation in part through HIF-1α suppression. Canagliflozin mediates transcriptional reprogramming of several metabolic and survival pathways known to be regulated by ETS and E2F family transcription factors. Genes downregulated by canagliflozin are associated with poor PC prognosis. This study lays the groundwork for clinical investigation of canagliflozin in PC prevention and treatment in combination with radiotherapy." @default.
• W4386545412 created "2023-09-09" @default.
• W4386545412 creator A5003830194 @default.
• W4386545412 creator A5004596436 @default.
• W4386545412 creator A5009277937 @default.
• W4386545412 creator A5018412533 @default.
• W4386545412 creator A5024749958 @default.
• W4386545412 creator A5029080896 @default.
• W4386545412 creator A5031536033 @default.
• W4386545412 creator A5031924160 @default.
• W4386545412 creator A5042906616 @default.
• W4386545412 creator A5043435077 @default.
• W4386545412 creator A5064403106 @default.
• W4386545412 creator A5065611718 @default.
• W4386545412 creator A5067222106 @default.
• W4386545412 creator A5076165905 @default.
• W4386545412 creator A5082504668 @default.
• W4386545412 creator A5087859751 @default.
• W4386545412 date "2023-09-08" @default.
• W4386545412 modified "2023-09-26" @default.
• W4386545412 title "The SGLT2 inhibitor canagliflozin suppresses growth and enhances prostate cancer response to radiotherapy" @default.
• W4386545412 cites W145853903 @default.
• W4386545412 cites W1581816996 @default.
• W4386545412 cites W1684904284 @default.
• W4386545412 cites W1919512980 @default.
• W4386545412 cites W1973116139 @default.
• W4386545412 cites W1982317652 @default.
• W4386545412 cites W2001775267 @default.
• W4386545412 cites W2007986629 @default.
• W4386545412 cites W2021784693 @default.
• W4386545412 cites W2036897871 @default.
• W4386545412 cites W2037679360 @default.
• W4386545412 cites W2066607735 @default.
• W4386545412 cites W2067356799 @default.
• W4386545412 cites W2067692539 @default.
• W4386545412 cites W2078467232 @default.
• W4386545412 cites W2079096821 @default.
• W4386545412 cites W2079537922 @default.
• W4386545412 cites W2081920342 @default.
• W4386545412 cites W2095761465 @default.
• W4386545412 cites W2098733695 @default.
• W4386545412 cites W2107281049 @default.
• W4386545412 cites W2111527534 @default.
• W4386545412 cites W2114969709 @default.
• W4386545412 cites W2117209575 @default.
• W4386545412 cites W2119151703 @default.
• W4386545412 cites W2130219349 @default.
• W4386545412 cites W2130410032 @default.
• W4386545412 cites W2130570549 @default.
• W4386545412 cites W2138207763 @default.
• W4386545412 cites W2144862658 @default.
• W4386545412 cites W2151834630 @default.
• W4386545412 cites W2159675211 @default.
• W4386545412 cites W2163116396 @default.
• W4386545412 cites W2164930186 @default.
• W4386545412 cites W2170488093 @default.
• W4386545412 cites W2179438025 @default.
• W4386545412 cites W2207522600 @default.
• W4386545412 cites W2223535266 @default.
• W4386545412 cites W2329659234 @default.
• W4386545412 cites W2431963657 @default.
• W4386545412 cites W2467821377 @default.
• W4386545412 cites W2516478359 @default.
• W4386545412 cites W2554514490 @default.
• W4386545412 cites W2587210054 @default.
• W4386545412 cites W2587210786 @default.
• W4386545412 cites W2588450094 @default.
• W4386545412 cites W2588464299 @default.
• W4386545412 cites W2590405411 @default.
• W4386545412 cites W2731282254 @default.
• W4386545412 cites W2767544488 @default.
• W4386545412 cites W2767670881 @default.
• W4386545412 cites W2773564421 @default.
• W4386545412 cites W2788841106 @default.
• W4386545412 cites W2796764897 @default.
• W4386545412 cites W2806128074 @default.
• W4386545412 cites W2897092653 @default.
• W4386545412 cites W2901276642 @default.
• W4386545412 cites W2924421333 @default.
• W4386545412 cites W2947014957 @default.
• W4386545412 cites W2947112537 @default.
• W4386545412 cites W2947893479 @default.
• W4386545412 cites W2950764390 @default.
• W4386545412 cites W2956532717 @default.
• W4386545412 cites W2964849163 @default.
• W4386545412 cites W2973514824 @default.
• W4386545412 cites W2995298233 @default.
• W4386545412 cites W3037252669 @default.
• W4386545412 cites W3091049124 @default.
• W4386545412 cites W3111149356 @default.
• W4386545412 cites W3128646645 @default.
• W4386545412 cites W3142978815 @default.
• W4386545412 cites W3166166721 @default.
• W4386545412 cites W3180266641 @default.
• W4386545412 cites W3197991594 @default.
• W4386545412 cites W3198846052 @default.
• W4386545412 cites W3202899348 @default.
• W4386545412 cites W3217589610 @default.
• W4386545412 cites W4200199725 @default.
• W4386545412 cites W4206907302 @default.

• next