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• W4386545758 abstract "The development, maintenance, and use of immune defences are costly. Therefore, animals face trade-offs in terms of resource allocation within their immune system and between their immune system and other physiological processes. To maximize fitness, evolution may favour investment in one immunological defence or subsystem over another in a way that matches a species broader life history strategy. Here, we used phylogenetically-informed comparative analyses to test for relationships between two immunological components. Natural antibodies and complement were used as proxies for the innate branch; structural complexity of the major histocompatibility complex (MHC) region was used for the acquired branch.We found a negative association between the levels of natural antibodies (i.e., haemagglutination titre) and the total MHC gene copy number across the avian phylogeny, both at the species and family level. The family-level analysis indicated that this association was apparent for both MHC-I and MHC-II, when copy numbers within these two MHC regions were analysed separately. The association remained significant after controlling for basic life history components and for ecological traits commonly linked to pathogen exposure.Our results provide the first phylogenetically robust evidence for an evolutionary trade-off within the avian immune system, with a more developed acquired immune system (i.e., more complex MHC architecture) in more derived bird lineages (e.g., passerines) being accompanied by an apparent downregulation of the innate immune system." @default.
• W4386545758 created "2023-09-09" @default.
• W4386545758 creator A5048736682 @default.
• W4386545758 creator A5072776757 @default.
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• W4386545758 date "2023-09-08" @default.
• W4386545758 modified "2023-10-16" @default.
• W4386545758 title "Evolutionary trade-off between innate and acquired immune defences in birds" @default.
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• W4386545758 doi "https://doi.org/10.1186/s12983-023-00511-1" @default.
• W4386545758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37684615" @default.
• W4386545758 hasPublicationYear "2023" @default.
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