FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386546905> ?p ?o ?g. }

• W4386546905 endingPage "13846" @default.
• W4386546905 startingPage "13846" @default.
• W4386546905 abstract "Amyloid β (Aβ) oligomers have been linked to Alzheimer's disease (AD) pathogenesis and are the main neurotoxic forms of Aβ. This review focuses on the following: (i) the Aβ(1-42):calmodulin interface as a model for the design of antagonist Aβ peptides and its limitations; (ii) proteolytic degradation as the major source of highly hydrophobic peptides in brain cells; and (iii) brain peptides that have been experimentally demonstrated to bind to Aβ monomers or oligomers, Aβ fibrils, or Aβ plaques. It is highlighted that the hydrophobic amino acid residues of the COOH-terminal segment of Aβ(1-42) play a key role in its interaction with intracellular protein partners linked to its neurotoxicity. The major source of highly hydrophobic endogenous peptides of 8-10 amino acids in neurons is the proteasome activity. Many canonical antigen peptides bound to the major histocompatibility complex class 1 are of this type. These highly hydrophobic peptides bind to Aβ and are likely to be efficient antagonists of the binding of Aβ monomers/oligomers concentrations in the nanomolar range with intracellular proteins. Also, their complexation with Aβ will protect them against endopeptidases, suggesting a putative chaperon-like physiological function for Aβ that has been overlooked until now. Remarkably, the hydrophobic amino acid residues of Aβ responsible for the binding of several neuropeptides partially overlap with those playing a key role in its interaction with intracellular protein partners that mediates its neurotoxicity. Therefore, these latter neuropeptides are also potential candidates to antagonize Aβ peptides binding to target proteins. In conclusion, the analysis performed in this review points out that hydrophobic endogenous brain neuropeptides could be valuable biomarkers to evaluate the risk of the onset of sporadic AD, as well as for the prognosis of AD." @default.
• W4386546905 created "2023-09-09" @default.
• W4386546905 creator A5046252340 @default.
• W4386546905 date "2023-09-08" @default.
• W4386546905 modified "2023-10-17" @default.
• W4386546905 title "Brain Hydrophobic Peptides Antagonists of Neurotoxic Amyloid β Peptide Monomers/Oligomers–Protein Interactions" @default.
• W4386546905 cites W1484780603 @default.
• W4386546905 cites W1538925586 @default.
• W4386546905 cites W1549159750 @default.
• W4386546905 cites W1551466091 @default.
• W4386546905 cites W1576911364 @default.
• W4386546905 cites W1580414793 @default.
• W4386546905 cites W1603448131 @default.
• W4386546905 cites W1683102335 @default.
• W4386546905 cites W1685999671 @default.
• W4386546905 cites W1837066325 @default.
• W4386546905 cites W1966646293 @default.
• W4386546905 cites W1967464880 @default.
• W4386546905 cites W1968721593 @default.
• W4386546905 cites W1969592336 @default.
• W4386546905 cites W1971302107 @default.
• W4386546905 cites W1972094490 @default.
• W4386546905 cites W1975304761 @default.
• W4386546905 cites W1975963996 @default.
• W4386546905 cites W1976201852 @default.
• W4386546905 cites W1981545549 @default.
• W4386546905 cites W1981840225 @default.
• W4386546905 cites W1982617198 @default.
• W4386546905 cites W1983882750 @default.
• W4386546905 cites W1984542598 @default.
• W4386546905 cites W1984678830 @default.
• W4386546905 cites W1988437687 @default.
• W4386546905 cites W1991185361 @default.
• W4386546905 cites W1991991142 @default.
• W4386546905 cites W1992263421 @default.
• W4386546905 cites W1993465897 @default.
• W4386546905 cites W1993682720 @default.
• W4386546905 cites W1995272223 @default.
• W4386546905 cites W1997703895 @default.
• W4386546905 cites W1997910595 @default.
• W4386546905 cites W1998208719 @default.
• W4386546905 cites W1998857798 @default.
• W4386546905 cites W2004354005 @default.
• W4386546905 cites W2005978992 @default.
• W4386546905 cites W2006696380 @default.
• W4386546905 cites W2008884445 @default.
• W4386546905 cites W2012308707 @default.
• W4386546905 cites W2016170408 @default.
• W4386546905 cites W2017524770 @default.
• W4386546905 cites W2022318321 @default.
• W4386546905 cites W2024069335 @default.
• W4386546905 cites W2027871457 @default.
• W4386546905 cites W2029532449 @default.
• W4386546905 cites W2030011352 @default.
• W4386546905 cites W2030165564 @default.
• W4386546905 cites W2030260517 @default.
• W4386546905 cites W2034969383 @default.
• W4386546905 cites W2036172794 @default.
• W4386546905 cites W2037069728 @default.
• W4386546905 cites W2037665410 @default.
• W4386546905 cites W2039049924 @default.
• W4386546905 cites W2040721710 @default.
• W4386546905 cites W2040863926 @default.
• W4386546905 cites W2040942754 @default.
• W4386546905 cites W2044005280 @default.
• W4386546905 cites W2046093999 @default.
• W4386546905 cites W2052216540 @default.
• W4386546905 cites W2055462017 @default.
• W4386546905 cites W2058268504 @default.
• W4386546905 cites W2059214757 @default.
• W4386546905 cites W2059305690 @default.
• W4386546905 cites W2061678835 @default.
• W4386546905 cites W2062350109 @default.
• W4386546905 cites W2062410112 @default.
• W4386546905 cites W2062834833 @default.
• W4386546905 cites W2063687229 @default.
• W4386546905 cites W2067616890 @default.
• W4386546905 cites W2069071040 @default.
• W4386546905 cites W2069121057 @default.
• W4386546905 cites W2071610287 @default.
• W4386546905 cites W2071692831 @default.
• W4386546905 cites W2076063919 @default.
• W4386546905 cites W2076215391 @default.
• W4386546905 cites W2079542677 @default.
• W4386546905 cites W2080276635 @default.
• W4386546905 cites W2081126811 @default.
• W4386546905 cites W2081621052 @default.
• W4386546905 cites W2082429191 @default.
• W4386546905 cites W2082452187 @default.
• W4386546905 cites W2082698296 @default.
• W4386546905 cites W2085760247 @default.
• W4386546905 cites W2086492334 @default.
• W4386546905 cites W2087923229 @default.
• W4386546905 cites W2088577455 @default.
• W4386546905 cites W2088733194 @default.
• W4386546905 cites W2089963291 @default.
• W4386546905 cites W2092662963 @default.
• W4386546905 cites W2094620748 @default.

• next