FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386559669> ?p ?o ?g. }

• W4386559669 endingPage "e0291108" @default.
• W4386559669 startingPage "e0291108" @default.
• W4386559669 abstract "Introduction The optimal analgesic modality for patients undergoing hepato-pancreato-biliary (HPB) surgery remains unknown. The analgesic effects of a multimodal intrathecal analgesia (MITA) technique of intrathecal morphine (ITM) in combination with clonidine and bupivacaine compared to ITM alone have not been investigated in these patients. Methods We performed a multicenter retrospective study of patients undergoing complex HPB surgery who received ITM, bupivacaine, and clonidine (MITA group) or ITM-only (ITM group) as part of their perioperative analgesia strategy. The primary outcome was the unadjusted oral morphine equivalent daily dose (oMEDD) in milligrams on postoperative day 1. After adjusting for age, body mass index, hospital allocation, type of surgery, operation length, and intraoperative opioid use, postoperative oMEDD use was investigated using a bootstrapped quantile regression model. Other prespecified outcomes included postoperative pain scores, opioid-related adverse events, major complications, and length of hospital stay. Results In total, 118 patients received MITA and 155 patients received ITM-only. The median (IQR) cumulative oMEDD use on postoperative day 1 was 20.5 mg (8.6:31.0) in the MITA group and 52.1 mg (18.0:107.0) in the ITM group (P < 0.001). There was a variation in the magnitude of the difference in oMEDD use between the groups for different quartiles. For the MITA group, on postoperative day 1, patients in the 25 th percentile required 14.0 mg less oMEDD (95% CI: -25.9 to -2.2; P = 0.025), patients in the 50 th percentile required 27.8 mg less oMEDD (95% CI: -49.7 to -6.0; P = 0.005), and patients in the 75 th percentile required 38.7 mg less oMEDD (95% CI: -72.2 to -5.1; P = 0.041) compared to patients in the same percentile of the ITM group. Patients in the MITA group had significantly lower pain scores in the postoperative recovery unit and on postoperative days 1 to 3. The incidence of postoperative respiratory depression was low (<1.5%) and similar between groups. Patients in the MITA group had a significantly higher incidence of postoperative hypotension requiring vasopressor support. However, no significant differences were observed in major postoperative complications, or the length of hospital stay. Conclusion In patients undergoing complex HPB surgery, the use of MITA, consisting of ITM in combination with intrathecal clonidine and bupivacaine, was associated with reduced postoperative opioid use and resulted in superior postoperative analgesia without risk of respiratory depression when compared to patients who received ITM alone. A randomized prospective clinical trial investigating these two intrathecal analgesic techniques is justified." @default.
• W4386559669 created "2023-09-09" @default.
• W4386559669 creator A5001618669 @default.
• W4386559669 creator A5001712451 @default.
• W4386559669 creator A5008173910 @default.
• W4386559669 creator A5015678099 @default.
• W4386559669 creator A5021490299 @default.
• W4386559669 creator A5029339790 @default.
• W4386559669 creator A5036295423 @default.
• W4386559669 creator A5042421293 @default.
• W4386559669 creator A5054693569 @default.
• W4386559669 creator A5063640914 @default.
• W4386559669 creator A5069892604 @default.
• W4386559669 creator A5078338355 @default.
• W4386559669 creator A5092829826 @default.
• W4386559669 date "2023-09-08" @default.
• W4386559669 modified "2023-09-27" @default.
• W4386559669 title "Multimodal intrathecal analgesia (MITA) with morphine for reducing postoperative opioid use and acute pain following hepato-pancreato-biliary surgery: A multicenter retrospective study" @default.
• W4386559669 cites W1532906040 @default.
• W4386559669 cites W1564050112 @default.
• W4386559669 cites W1687620054 @default.
• W4386559669 cites W1955425308 @default.
• W4386559669 cites W1968906326 @default.
• W4386559669 cites W1972318888 @default.
• W4386559669 cites W1973629912 @default.
• W4386559669 cites W1974528316 @default.
• W4386559669 cites W1979587567 @default.
• W4386559669 cites W1987343036 @default.
• W4386559669 cites W1990002421 @default.
• W4386559669 cites W1992331709 @default.
• W4386559669 cites W1994339664 @default.
• W4386559669 cites W2030162118 @default.
• W4386559669 cites W2031956659 @default.
• W4386559669 cites W2034722506 @default.
• W4386559669 cites W2058464386 @default.
• W4386559669 cites W2074244581 @default.
• W4386559669 cites W2081353372 @default.
• W4386559669 cites W2082916459 @default.
• W4386559669 cites W2083598430 @default.
• W4386559669 cites W2092894266 @default.
• W4386559669 cites W2093865698 @default.
• W4386559669 cites W2096998881 @default.
• W4386559669 cites W2101795926 @default.
• W4386559669 cites W2107017192 @default.
• W4386559669 cites W2136909022 @default.
• W4386559669 cites W2139779985 @default.
• W4386559669 cites W2144073336 @default.
• W4386559669 cites W2148005822 @default.
• W4386559669 cites W2292682700 @default.
• W4386559669 cites W2519653132 @default.
• W4386559669 cites W2553653068 @default.
• W4386559669 cites W2554987853 @default.
• W4386559669 cites W2734164949 @default.
• W4386559669 cites W2922060572 @default.
• W4386559669 cites W2961710704 @default.
• W4386559669 cites W2994079575 @default.
• W4386559669 cites W2994853723 @default.
• W4386559669 cites W3152869059 @default.
• W4386559669 cites W3175360839 @default.
• W4386559669 cites W3176884208 @default.
• W4386559669 cites W4242190452 @default.
• W4386559669 cites W4307650856 @default.
• W4386559669 doi "https://doi.org/10.1371/journal.pone.0291108" @default.
• W4386559669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37682837" @default.
• W4386559669 hasPublicationYear "2023" @default.
• W4386559669 type Work @default.
• W4386559669 citedByCount "0" @default.
• W4386559669 crossrefType "journal-article" @default.
• W4386559669 hasAuthorship W4386559669A5001618669 @default.
• W4386559669 hasAuthorship W4386559669A5001712451 @default.
• W4386559669 hasAuthorship W4386559669A5008173910 @default.
• W4386559669 hasAuthorship W4386559669A5015678099 @default.
• W4386559669 hasAuthorship W4386559669A5021490299 @default.
• W4386559669 hasAuthorship W4386559669A5029339790 @default.
• W4386559669 hasAuthorship W4386559669A5036295423 @default.
• W4386559669 hasAuthorship W4386559669A5042421293 @default.
• W4386559669 hasAuthorship W4386559669A5054693569 @default.
• W4386559669 hasAuthorship W4386559669A5063640914 @default.
• W4386559669 hasAuthorship W4386559669A5069892604 @default.
• W4386559669 hasAuthorship W4386559669A5078338355 @default.
• W4386559669 hasAuthorship W4386559669A5092829826 @default.
• W4386559669 hasBestOaLocation W43865596691 @default.
• W4386559669 hasConcept C126322002 @default.
• W4386559669 hasConcept C141071460 @default.
• W4386559669 hasConcept C167135981 @default.
• W4386559669 hasConcept C170493617 @default.
• W4386559669 hasConcept C197934379 @default.
• W4386559669 hasConcept C2776277131 @default.
• W4386559669 hasConcept C2777389121 @default.
• W4386559669 hasConcept C2778399450 @default.
• W4386559669 hasConcept C2778891214 @default.
• W4386559669 hasConcept C2780120127 @default.
• W4386559669 hasConcept C2780820201 @default.
• W4386559669 hasConcept C2781063702 @default.
• W4386559669 hasConcept C2781328992 @default.
• W4386559669 hasConcept C31174226 @default.
• W4386559669 hasConcept C42219234 @default.
• W4386559669 hasConcept C44249647 @default.

• next