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- W4386559765 abstract "Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream genes transcription by binding to their antioxidant response elements (AREs). Numerous studies suggest that NRF2 assumes an extremely important role in the regulation of ferroptosis, for its various functions in iron, lipid, and amino acid metabolism, and so on. Many pathological states are relevant to ferroptosis. Abnormal suppression of ferroptosis is found in many cases of cancer, promoting their progression and metastasis. While during tissue damages, ferroptosis is recurrently promoted, resulting in a large number of cell deaths and even dysfunctions of the corresponding organs. Therefore, targeting NRF2-related signaling pathways, to induce or inhibit ferroptosis, has become a great potential therapy for combating cancers, as well as preventing neurodegenerative and ischemic diseases. In this review, a brief overview of the research process of ferroptosis over the past decade will be presented. In particular, the mechanisms of ferroptosis and a focus on the regulation of ferroptosis by NRF2 will be discussed. Finally, the review will briefly list some clinical applications of targeting the NRF2 signaling pathway in the treatment of diseases." @default.
- W4386559765 created "2023-09-09" @default.
- W4386559765 creator A5008450538 @default.
- W4386559765 creator A5022311318 @default.
- W4386559765 creator A5028018251 @default.
- W4386559765 creator A5051909246 @default.
- W4386559765 creator A5065835305 @default.
- W4386559765 creator A5070538689 @default.
- W4386559765 date "2023-09-08" @default.
- W4386559765 modified "2023-10-14" @default.
- W4386559765 title "NRF2, a Superstar of Ferroptosis" @default.
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