FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386560168> ?p ?o ?g. }

• W4386560168 abstract "Abstract Across the human genome, there are large-scale fluctuations in genetic diversity caused by the indirect effects of selection. This “linked selection signal” reflects the impact of selection according to the physical placement of functional regions and recombination rates along chromosomes. Previous work has shown that purifying selection acting against the steady influx of new deleterious mutations at functional portions of the genome shapes patterns of genomic variation. To date, statistical efforts to estimate purifying selection parameters from linked selection models have relied on classic Background Selection theory, which is only applicable when new mutations are so deleterious that they cannot fix in the population. Here, we develop a statistical method based on a quantitative genetics view of linked selection, that models how polygenic additive fitness variance distributed along the genome increases the rate of stochastic allele frequency change. By jointly predicting the equilibrium fitness variance and substitution rate due to both strong and weakly deleterious mutations, we estimate the distribution of fitness effects (DFE) and mutation rate across three geographically distinct human samples. While our model can accommodate weaker selection, we find evidence of strong selection operating similarly across all human samples. Although our quantitative genetic model of linked selection fits better than previous models, substitution rates of the most constrained sites disagree with observed divergence levels. We find that a model incorporating selective interference better predicts observed divergence in conserved regions, but overall our results suggest uncertainty remains about the processes generating fitness variation in humans." @default.
• W4386560168 created "2023-09-09" @default.
• W4386560168 creator A5005571919 @default.
• W4386560168 creator A5031060406 @default.
• W4386560168 date "2023-09-08" @default.
• W4386560168 modified "2023-09-30" @default.
• W4386560168 title "A Quantitative Genetic Model of Background Selection in Humans" @default.
• W4386560168 cites W1900103465 @default.
• W4386560168 cites W1918516970 @default.
• W4386560168 cites W1925508000 @default.
• W4386560168 cites W1930635754 @default.
• W4386560168 cites W1932703700 @default.
• W4386560168 cites W1960821792 @default.
• W4386560168 cites W1976284211 @default.
• W4386560168 cites W1989923963 @default.
• W4386560168 cites W1994066804 @default.
• W4386560168 cites W1994975196 @default.
• W4386560168 cites W2001036195 @default.
• W4386560168 cites W2001320321 @default.
• W4386560168 cites W2009132217 @default.
• W4386560168 cites W2014300152 @default.
• W4386560168 cites W2026503542 @default.
• W4386560168 cites W2027327351 @default.
• W4386560168 cites W2032105952 @default.
• W4386560168 cites W2032311106 @default.
• W4386560168 cites W2033995133 @default.
• W4386560168 cites W2045716211 @default.
• W4386560168 cites W2053731023 @default.
• W4386560168 cites W2084407487 @default.
• W4386560168 cites W2091851394 @default.
• W4386560168 cites W2098001104 @default.
• W4386560168 cites W2098460741 @default.
• W4386560168 cites W2099143009 @default.
• W4386560168 cites W2103656106 @default.
• W4386560168 cites W2104549677 @default.
• W4386560168 cites W2105409312 @default.
• W4386560168 cites W2106756635 @default.
• W4386560168 cites W2119500014 @default.
• W4386560168 cites W2122977880 @default.
• W4386560168 cites W2125300654 @default.
• W4386560168 cites W2130315111 @default.
• W4386560168 cites W2131494350 @default.
• W4386560168 cites W2139619894 @default.
• W4386560168 cites W2145191876 @default.
• W4386560168 cites W2147476214 @default.
• W4386560168 cites W2149238797 @default.
• W4386560168 cites W2149943693 @default.
• W4386560168 cites W2160995259 @default.
• W4386560168 cites W2256016639 @default.
• W4386560168 cites W2523774201 @default.
• W4386560168 cites W2797293309 @default.
• W4386560168 cites W2891696188 @default.
• W4386560168 cites W2894396559 @default.
• W4386560168 cites W2905452503 @default.
• W4386560168 cites W2915041973 @default.
• W4386560168 cites W2950232895 @default.
• W4386560168 cites W2950732129 @default.
• W4386560168 cites W2951448613 @default.
• W4386560168 cites W2952902252 @default.
• W4386560168 cites W2953136938 @default.
• W4386560168 cites W2970112352 @default.
• W4386560168 cites W2977922357 @default.
• W4386560168 cites W3008091198 @default.
• W4386560168 cites W3011565822 @default.
• W4386560168 cites W3103523614 @default.
• W4386560168 cites W4200135473 @default.
• W4386560168 cites W4251304755 @default.
• W4386560168 cites W4253414868 @default.
• W4386560168 cites W4294012180 @default.
• W4386560168 cites W4316928342 @default.
• W4386560168 cites W4319459561 @default.
• W4386560168 cites W91426214 @default.
• W4386560168 doi "https://doi.org/10.1101/2023.09.07.556762" @default.
• W4386560168 hasPublicationYear "2023" @default.
• W4386560168 type Work @default.
• W4386560168 citedByCount "0" @default.
• W4386560168 crossrefType "posted-content" @default.
• W4386560168 hasAuthorship W4386560168A5005571919 @default.
• W4386560168 hasAuthorship W4386560168A5031060406 @default.
• W4386560168 hasConcept C104317684 @default.
• W4386560168 hasConcept C119857082 @default.
• W4386560168 hasConcept C137848329 @default.
• W4386560168 hasConcept C141231307 @default.
• W4386560168 hasConcept C144024400 @default.
• W4386560168 hasConcept C149923435 @default.
• W4386560168 hasConcept C2908647359 @default.
• W4386560168 hasConcept C41008148 @default.
• W4386560168 hasConcept C54355233 @default.
• W4386560168 hasConcept C68873052 @default.
• W4386560168 hasConcept C7386963 @default.
• W4386560168 hasConcept C78458016 @default.
• W4386560168 hasConcept C81917197 @default.
• W4386560168 hasConcept C86803240 @default.
• W4386560168 hasConceptScore W4386560168C104317684 @default.
• W4386560168 hasConceptScore W4386560168C119857082 @default.
• W4386560168 hasConceptScore W4386560168C137848329 @default.
• W4386560168 hasConceptScore W4386560168C141231307 @default.
• W4386560168 hasConceptScore W4386560168C144024400 @default.
• W4386560168 hasConceptScore W4386560168C149923435 @default.
• W4386560168 hasConceptScore W4386560168C2908647359 @default.

• next