FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386562716> ?p ?o ?g. }

• W4386562716 abstract "Abstract Artificial selection has been widely applied to genetically fix rare phenotypic features in ornamental domesticated animals. For many of these animals, the mutated loci and alleles underlying rare phenotypes are known. However, few studies have explored whether these rare genetic mutations might have been fixed due to competition among related mutated alleles or if the fixation occurred due to contingent stochastic events. Here, we performed genetic crossing with twin-tail ornamental goldfish and CRISPR/Cas9-mutated goldfish to investigate why only a single mutated allele – chdS with a E127X stop codon (also called chdA E127X ) – gives rise to the twin-tail phenotype in the modern domesticated goldfish population. Two closely related chdS mutants were generated with CRISPR/Cas9 and compared with the E127X allele in F2 and F3 generations. Both of the CRISPR/Cas9-generated alleles were equivalent to the E127X allele in terms of penetrance/expressivity of the twin-tail phenotype and viability of carriers. These findings indicate that multiple truncating mutations could have produced viable twin-tail goldfish. Therefore, the absence of polymorphic alleles for the twin-tail phenotype in modern goldfish likely stems from stochastic elimination or a lack of competing alleles in the common ancestor. Our study is the first experimental comparison of a singular domestication-derived allele with CRISPR/Cas9-generated alleles to understand how genetic fixation of a unique genotype and phenotype may have occurred. Thus, our work may provide a conceptual framework for future investigations of rare evolutionary events in domesticated animals." @default.
• W4386562716 created "2023-09-10" @default.
• W4386562716 creator A5002556951 @default.
• W4386562716 creator A5014109619 @default.
• W4386562716 creator A5035683322 @default.
• W4386562716 creator A5060467801 @default.
• W4386562716 creator A5083097926 @default.
• W4386562716 date "2023-09-08" @default.
• W4386562716 modified "2023-10-16" @default.
• W4386562716 title "Competition or contingency? Using CRISPR/Cas9-induced mutants to examine the potential origin of a unique mutant allele in twin-tail goldfish" @default.
• W4386562716 cites W1509868604 @default.
• W4386562716 cites W1657005131 @default.
• W4386562716 cites W1776954300 @default.
• W4386562716 cites W1842953786 @default.
• W4386562716 cites W1893979090 @default.
• W4386562716 cites W1983704731 @default.
• W4386562716 cites W1984011890 @default.
• W4386562716 cites W1989363259 @default.
• W4386562716 cites W1996709598 @default.
• W4386562716 cites W1997662814 @default.
• W4386562716 cites W1998984510 @default.
• W4386562716 cites W2000788932 @default.
• W4386562716 cites W2020516785 @default.
• W4386562716 cites W2048532439 @default.
• W4386562716 cites W2052474365 @default.
• W4386562716 cites W2062533068 @default.
• W4386562716 cites W2080374649 @default.
• W4386562716 cites W2083194102 @default.
• W4386562716 cites W2085024301 @default.
• W4386562716 cites W2114719552 @default.
• W4386562716 cites W2125068279 @default.
• W4386562716 cites W2142762977 @default.
• W4386562716 cites W2143532229 @default.
• W4386562716 cites W2146102776 @default.
• W4386562716 cites W2162568753 @default.
• W4386562716 cites W2164754859 @default.
• W4386562716 cites W2194192871 @default.
• W4386562716 cites W2300193365 @default.
• W4386562716 cites W2322369524 @default.
• W4386562716 cites W2395459192 @default.
• W4386562716 cites W2559096641 @default.
• W4386562716 cites W2560005905 @default.
• W4386562716 cites W2756289581 @default.
• W4386562716 cites W2792254596 @default.
• W4386562716 cites W2898677625 @default.
• W4386562716 cites W2911636617 @default.
• W4386562716 cites W2920863117 @default.
• W4386562716 cites W2977549339 @default.
• W4386562716 cites W3005472609 @default.
• W4386562716 cites W3022578373 @default.
• W4386562716 cites W4206099957 @default.
• W4386562716 doi "https://doi.org/10.21203/rs.3.rs-3261726/v1" @default.
• W4386562716 hasPublicationYear "2023" @default.
• W4386562716 type Work @default.
• W4386562716 citedByCount "0" @default.
• W4386562716 crossrefType "posted-content" @default.
• W4386562716 hasAuthorship W4386562716A5002556951 @default.
• W4386562716 hasAuthorship W4386562716A5014109619 @default.
• W4386562716 hasAuthorship W4386562716A5035683322 @default.
• W4386562716 hasAuthorship W4386562716A5060467801 @default.
• W4386562716 hasAuthorship W4386562716A5083097926 @default.
• W4386562716 hasConcept C104317684 @default.
• W4386562716 hasConcept C127716648 @default.
• W4386562716 hasConcept C132455925 @default.
• W4386562716 hasConcept C135763542 @default.
• W4386562716 hasConcept C144024400 @default.
• W4386562716 hasConcept C149923435 @default.
• W4386562716 hasConcept C180754005 @default.
• W4386562716 hasConcept C200544954 @default.
• W4386562716 hasConcept C2908647359 @default.
• W4386562716 hasConcept C54355233 @default.
• W4386562716 hasConcept C86803240 @default.
• W4386562716 hasConcept C98108389 @default.
• W4386562716 hasConceptScore W4386562716C104317684 @default.
• W4386562716 hasConceptScore W4386562716C127716648 @default.
• W4386562716 hasConceptScore W4386562716C132455925 @default.
• W4386562716 hasConceptScore W4386562716C135763542 @default.
• W4386562716 hasConceptScore W4386562716C144024400 @default.
• W4386562716 hasConceptScore W4386562716C149923435 @default.
• W4386562716 hasConceptScore W4386562716C180754005 @default.
• W4386562716 hasConceptScore W4386562716C200544954 @default.
• W4386562716 hasConceptScore W4386562716C2908647359 @default.
• W4386562716 hasConceptScore W4386562716C54355233 @default.
• W4386562716 hasConceptScore W4386562716C86803240 @default.
• W4386562716 hasConceptScore W4386562716C98108389 @default.
• W4386562716 hasLocation W43865627161 @default.
• W4386562716 hasOpenAccess W4386562716 @default.
• W4386562716 hasPrimaryLocation W43865627161 @default.
• W4386562716 hasRelatedWork W1987585879 @default.
• W4386562716 hasRelatedWork W2053763858 @default.
• W4386562716 hasRelatedWork W2056833586 @default.
• W4386562716 hasRelatedWork W2057739827 @default.
• W4386562716 hasRelatedWork W2058792860 @default.
• W4386562716 hasRelatedWork W2075569090 @default.
• W4386562716 hasRelatedWork W2084589121 @default.
• W4386562716 hasRelatedWork W2199926692 @default.
• W4386562716 hasRelatedWork W2902341958 @default.
• W4386562716 hasRelatedWork W3206047998 @default.
• W4386562716 isParatext "false" @default.
• W4386562716 isRetracted "false" @default.

• next