Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386564005> ?p ?o ?g. }
- W4386564005 endingPage "4466" @default.
- W4386564005 startingPage "4466" @default.
- W4386564005 abstract "Prior to clinical trials, preclinical testing of oncology drug candidates is performed by evaluating drug candidates with in vitro and in vivo platforms. For in vivo testing, animal models are used to evaluate the toxicity and efficacy of drug candidates. However, animal models often display poor translational results as many drugs that pass preclinical testing fail when tested with humans, with oncology drugs exhibiting especially poor acceptance rates. The FDA Modernization Act 2.0 promotes alternative preclinical testing techniques, presenting the opportunity to use higher complexity in vitro models as an alternative to in vivo testing, including three-dimensional (3D) cell culture models. Three-dimensional tissue cultures address many of the shortcomings of 2D cultures by more closely replicating the tumour microenvironment through a combination of physiologically relevant drug diffusion, paracrine signalling, cellular phenotype, and vascularization that can better mimic native human tissue. This review will discuss the common forms of 3D cell culture, including cell spheroids, organoids, organs-on-a-chip, and 3D bioprinted tissues. Their advantages and limitations will be presented, aiming to discuss the use of these 3D models to accurately represent human tissue and as an alternative to animal testing. The use of 3D culture platforms for preclinical drug development is expected to accelerate as these platforms continue to improve in complexity, reliability, and translational predictivity." @default.
- W4386564005 created "2023-09-10" @default.
- W4386564005 creator A5007260003 @default.
- W4386564005 creator A5081165229 @default.
- W4386564005 creator A5092583630 @default.
- W4386564005 date "2023-09-07" @default.
- W4386564005 modified "2023-10-17" @default.
- W4386564005 title "Preclinical Testing Techniques: Paving the Way for New Oncology Screening Approaches" @default.
- W4386564005 cites W1795050634 @default.
- W4386564005 cites W1924088822 @default.
- W4386564005 cites W1944943742 @default.
- W4386564005 cites W1971500643 @default.
- W4386564005 cites W1971500740 @default.
- W4386564005 cites W1979892184 @default.
- W4386564005 cites W1981684516 @default.
- W4386564005 cites W1982570701 @default.
- W4386564005 cites W1991262047 @default.
- W4386564005 cites W1992524877 @default.
- W4386564005 cites W1994943804 @default.
- W4386564005 cites W1996266076 @default.
- W4386564005 cites W1996269383 @default.
- W4386564005 cites W2008434550 @default.
- W4386564005 cites W2011244979 @default.
- W4386564005 cites W2024229755 @default.
- W4386564005 cites W2024631759 @default.
- W4386564005 cites W2025668847 @default.
- W4386564005 cites W2030621071 @default.
- W4386564005 cites W2032522622 @default.
- W4386564005 cites W2032695302 @default.
- W4386564005 cites W2033712039 @default.
- W4386564005 cites W2035894835 @default.
- W4386564005 cites W2039414616 @default.
- W4386564005 cites W2043423139 @default.
- W4386564005 cites W2043745475 @default.
- W4386564005 cites W2044928246 @default.
- W4386564005 cites W2046263184 @default.
- W4386564005 cites W2051281301 @default.
- W4386564005 cites W2055699288 @default.
- W4386564005 cites W2066523597 @default.
- W4386564005 cites W2070152626 @default.
- W4386564005 cites W2078246403 @default.
- W4386564005 cites W2078653911 @default.
- W4386564005 cites W2081881447 @default.
- W4386564005 cites W2086187432 @default.
- W4386564005 cites W2122920174 @default.
- W4386564005 cites W2133481922 @default.
- W4386564005 cites W2146836367 @default.
- W4386564005 cites W2149672704 @default.
- W4386564005 cites W2160245738 @default.
- W4386564005 cites W2161162374 @default.
- W4386564005 cites W2168528461 @default.
- W4386564005 cites W2171925711 @default.
- W4386564005 cites W2196083197 @default.
- W4386564005 cites W2213638339 @default.
- W4386564005 cites W2288763182 @default.
- W4386564005 cites W2288833777 @default.
- W4386564005 cites W2335098955 @default.
- W4386564005 cites W2344408149 @default.
- W4386564005 cites W2471485002 @default.
- W4386564005 cites W2476542314 @default.
- W4386564005 cites W2533859605 @default.
- W4386564005 cites W2545768818 @default.
- W4386564005 cites W2559082960 @default.
- W4386564005 cites W2561294399 @default.
- W4386564005 cites W2562982267 @default.
- W4386564005 cites W2580948701 @default.
- W4386564005 cites W2600237894 @default.
- W4386564005 cites W2602946395 @default.
- W4386564005 cites W2728647424 @default.
- W4386564005 cites W2736845893 @default.
- W4386564005 cites W2751010866 @default.
- W4386564005 cites W2752377971 @default.
- W4386564005 cites W2769113543 @default.
- W4386564005 cites W2774971110 @default.
- W4386564005 cites W2792014894 @default.
- W4386564005 cites W2793367223 @default.
- W4386564005 cites W2797163462 @default.
- W4386564005 cites W2799444748 @default.
- W4386564005 cites W2800159482 @default.
- W4386564005 cites W2800428612 @default.
- W4386564005 cites W2804110020 @default.
- W4386564005 cites W2805153996 @default.
- W4386564005 cites W2807291660 @default.
- W4386564005 cites W2809513490 @default.
- W4386564005 cites W2868361013 @default.
- W4386564005 cites W2885351238 @default.
- W4386564005 cites W2890629472 @default.
- W4386564005 cites W2890912772 @default.
- W4386564005 cites W2893723812 @default.
- W4386564005 cites W2894838389 @default.
- W4386564005 cites W2901220507 @default.
- W4386564005 cites W2901406952 @default.
- W4386564005 cites W2902499520 @default.
- W4386564005 cites W2902585499 @default.
- W4386564005 cites W2904695287 @default.
- W4386564005 cites W2907304027 @default.
- W4386564005 cites W2907897113 @default.
- W4386564005 cites W2909044460 @default.