Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386564585> ?p ?o ?g. }
- W4386564585 abstract "Adipose-derived stem cells (ADSCs) are employed as a promising alternative in treating cartilage injury. Regulating the inflammatory “fingerprint” of ADSCs to improve their anti-inflammatory properties could enhance therapy efficiency. Herein, a novel injectable decorin/gellan gum hydrogel combined with ADSCs encapsulation for arthritis cartilage treatment is proposed. Decorin/gellan gum hydrogel was prepared according to the previous manufacturing protocol. The liquid–solid form transition of gellan gum hydrogel is perfectly suitable for intra-articular injection. Decorin-enriched matrix showing an immunomodulatory ability to enhance ADSCs anti-inflammatory phenotype under inflammation microenvironment by regulating autophagy signaling. This decorin/gellan gum/ADSCs hydrogel efficiently reverses interleukin-1β-induced cellular injury in chondrocytes. Through a mono-iodoacetate-induced arthritis mice model, the synergistic therapeutic effect of this ADSCs-loaded hydrogel, including inflammation attenuation and cartilage protection, is demonstrated. These results make the decorin/gellan gum hydrogel laden with ADSCs an ideal candidate for treating inflammatory joint disorders." @default.
- W4386564585 created "2023-09-10" @default.
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- W4386564585 date "2023-01-01" @default.
- W4386564585 modified "2023-09-27" @default.
- W4386564585 title "Injectable Decorin/Gellan Gum Hydrogel Encapsulating Adipose-Derived Stem Cells Enhances Anti-Inflammatory Effect in Cartilage Injury via Autophagy Signaling" @default.
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- W4386564585 doi "https://doi.org/10.1177/09636897231196493" @default.
- W4386564585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37688441" @default.
- W4386564585 hasPublicationYear "2023" @default.
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