Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386564618> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4386564618 abstract "Diterpenoid alkaloids (DAs) have been often utilized in clinical practice due to their analgesic and anti-inflammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Nevertheless, the evolutionary origin of the biosynthesis pathways responsible for DA production remains unknown. In this study, we successfully assembled a high-quality, pseudochromosome-level genome of the DA-rich species Aconitum vilmorinianum (5.76 Gb). An A. vilmorinianum-specific whole-genome duplication event was discovered using comparative genomic analysis, which may aid in the evolution of DA biosynthesis pathway. We identified several genes involved in DA biosynthesis via integrated genomic, transcriptomic, and metabolomic analyses. These genes included enzymes encoding target ent-kaurene oxidases and aminotransferases, which facilitated the activation of diterpenes and insertion of nitrogen atoms into diterpene skeletons, thereby mediating the transformation of diterpenes into DAs. The divergence periods of these genes in A. vilmorinianum were further assessed, and it was shown that two major types of genes were involved in the establishment of the DA biosynthesis pathway. Our integrated analysis offers fresh insights into the evolutionary origins of DAs in A. vilmorinianum as well as suggestions for engineering the biosynthetic pathways to obtain desired DAs. This article is protected by copyright. All rights reserved." @default.
- W4386564618 created "2023-09-10" @default.
- W4386564618 creator A5016572109 @default.
- W4386564618 creator A5016898529 @default.
- W4386564618 creator A5022284072 @default.
- W4386564618 creator A5024826644 @default.
- W4386564618 creator A5030202287 @default.
- W4386564618 creator A5042669573 @default.
- W4386564618 creator A5046028600 @default.
- W4386564618 creator A5049965329 @default.
- W4386564618 creator A5060789335 @default.
- W4386564618 creator A5060803691 @default.
- W4386564618 creator A5077356282 @default.
- W4386564618 creator A5078132082 @default.
- W4386564618 creator A5078137307 @default.
- W4386564618 creator A5079171854 @default.
- W4386564618 creator A5088950998 @default.
- W4386564618 date "2023-09-08" @default.
- W4386564618 modified "2023-09-26" @default.
- W4386564618 title "Multi‐omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in <i>Aconitum</i>" @default.
- W4386564618 doi "https://doi.org/10.1111/jipb.13565" @default.
- W4386564618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37688324" @default.
- W4386564618 hasPublicationYear "2023" @default.
- W4386564618 type Work @default.
- W4386564618 citedByCount "0" @default.
- W4386564618 crossrefType "journal-article" @default.
- W4386564618 hasAuthorship W4386564618A5016572109 @default.
- W4386564618 hasAuthorship W4386564618A5016898529 @default.
- W4386564618 hasAuthorship W4386564618A5022284072 @default.
- W4386564618 hasAuthorship W4386564618A5024826644 @default.
- W4386564618 hasAuthorship W4386564618A5030202287 @default.
- W4386564618 hasAuthorship W4386564618A5042669573 @default.
- W4386564618 hasAuthorship W4386564618A5046028600 @default.
- W4386564618 hasAuthorship W4386564618A5049965329 @default.
- W4386564618 hasAuthorship W4386564618A5060789335 @default.
- W4386564618 hasAuthorship W4386564618A5060803691 @default.
- W4386564618 hasAuthorship W4386564618A5077356282 @default.
- W4386564618 hasAuthorship W4386564618A5078132082 @default.
- W4386564618 hasAuthorship W4386564618A5078137307 @default.
- W4386564618 hasAuthorship W4386564618A5079171854 @default.
- W4386564618 hasAuthorship W4386564618A5088950998 @default.
- W4386564618 hasBestOaLocation W43865646181 @default.
- W4386564618 hasConcept C104317684 @default.
- W4386564618 hasConcept C141231307 @default.
- W4386564618 hasConcept C150194340 @default.
- W4386564618 hasConcept C162317418 @default.
- W4386564618 hasConcept C2776710815 @default.
- W4386564618 hasConcept C2777667214 @default.
- W4386564618 hasConcept C2779411416 @default.
- W4386564618 hasConcept C2780029364 @default.
- W4386564618 hasConcept C54355233 @default.
- W4386564618 hasConcept C553450214 @default.
- W4386564618 hasConcept C55493867 @default.
- W4386564618 hasConcept C59822182 @default.
- W4386564618 hasConcept C70721500 @default.
- W4386564618 hasConcept C7602840 @default.
- W4386564618 hasConcept C86803240 @default.
- W4386564618 hasConceptScore W4386564618C104317684 @default.
- W4386564618 hasConceptScore W4386564618C141231307 @default.
- W4386564618 hasConceptScore W4386564618C150194340 @default.
- W4386564618 hasConceptScore W4386564618C162317418 @default.
- W4386564618 hasConceptScore W4386564618C2776710815 @default.
- W4386564618 hasConceptScore W4386564618C2777667214 @default.
- W4386564618 hasConceptScore W4386564618C2779411416 @default.
- W4386564618 hasConceptScore W4386564618C2780029364 @default.
- W4386564618 hasConceptScore W4386564618C54355233 @default.
- W4386564618 hasConceptScore W4386564618C553450214 @default.
- W4386564618 hasConceptScore W4386564618C55493867 @default.
- W4386564618 hasConceptScore W4386564618C59822182 @default.
- W4386564618 hasConceptScore W4386564618C70721500 @default.
- W4386564618 hasConceptScore W4386564618C7602840 @default.
- W4386564618 hasConceptScore W4386564618C86803240 @default.
- W4386564618 hasLocation W43865646181 @default.
- W4386564618 hasLocation W43865646182 @default.
- W4386564618 hasOpenAccess W4386564618 @default.
- W4386564618 hasPrimaryLocation W43865646181 @default.
- W4386564618 hasRelatedWork W1587622005 @default.
- W4386564618 hasRelatedWork W2180579393 @default.
- W4386564618 hasRelatedWork W2317687894 @default.
- W4386564618 hasRelatedWork W2596108460 @default.
- W4386564618 hasRelatedWork W2944771632 @default.
- W4386564618 hasRelatedWork W3023720403 @default.
- W4386564618 hasRelatedWork W4229070176 @default.
- W4386564618 hasRelatedWork W4297142643 @default.
- W4386564618 hasRelatedWork W4386003883 @default.
- W4386564618 hasRelatedWork W2043930162 @default.
- W4386564618 isParatext "false" @default.
- W4386564618 isRetracted "false" @default.
- W4386564618 workType "article" @default.