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• W4386566215 abstract "The adjuvant endocrine therapy (AET) of HR+ EBC has been changing in recent years. Aromatase inhibitors (AIs) as an upfront strategy (or as part of a switch strategy) have been added to the choice of Tamoxifen (T) alone. Increased TE risk is well known in T-treated patients, while AIs have shown a reduced TE rate. By adding the cyclin dependent kinase 4/6 inhibitors (CDK4/6) to AIs, an increase in TE rate has been shown. We conducted this meta-analysis to evaluate the impact of the AETs on TE incidence. Twelve randomized phase III trials were included. Four trials evaluated the upfront strategy, six assessed the switch and two the combination with a CDK4/6 inhibitor. The new AETs did not significantly modify or affect the rate of TE events (OR 0.847, 95% IC 0.528-1.366, p=0.489). The OR for CDK4/6 inhibitor plus ET vs ET was 3.635 (p=0.002). Excluding the CDK4/6 inhibitors, the overall OR for AIs vs T was 0.628 (p <0.001), while it was 0.781 (p=0.151) for switching T vs. continuing T for 5 years, and 0.52 (p<0.0001) for the upfront strategies with AIs. The AIs alone or plus CDK4/6 inhibitors did not affect the rate of TE events. AIs as an upfront strategy is the safest AET, associated with the lowest TE incidence. The switch strategy increases TE rate, whereas the addition of CDK4/6 to the standard AET was shown to significantly increase TE events. The results of the currently ongoing trials with CDK4/6 inhibitors will help obtain additional data to evaluate any differences among the different CDK4/6 inhibitors and clarify the weight of TE adverse events in the benefit/risk balance of this new adjuvant strategy." @default.
• W4386566215 created "2023-09-10" @default.
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• W4386566215 date "2023-09-01" @default.
• W4386566215 modified "2023-10-14" @default.
• W4386566215 title "Thromboembolism and adjuvant endocrine therapy (AET) in hormone receptor-positive early breast cancer (EBC): Did treatment evolution change incidence of the adverse event? A meta-analysis." @default.
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• W4386566215 doi "https://doi.org/10.1016/j.clbc.2023.09.002" @default.
• W4386566215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37775349" @default.
• W4386566215 hasPublicationYear "2023" @default.
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