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- W4386567759 abstract "Summary Stem cells often rely on signals from a niche, which in many tissues adopts a precise morphology. What remains elusive is how niches are formed, and how morphology impacts function. To address this, we leverage the Drosophila gonadal niche, combining genetic tractability with live-imaging. We have previously shown that proper positioning of niche cells relies on signaling from visceral mesoderm. Here, we show that once positioned, niche cells robustly polarize filamentous actin and Non-muscle Myosin II (MyoII) towards neighboring germ cells. Actomyosin tension along the niche periphery generates a highly reproducible smoothened contour. Without contractility, niches are misshapen and exhibit defects in their ability to regulate germline stem cell behavior. We additionally show that germ cells aid in polarizing MyoII within niche cells, and that extrinsic input is required for niche morphogenesis and function. Our work reveals a feedback mechanism where stem cells shape the niche that guides their behavior." @default.
- W4386567759 created "2023-09-10" @default.
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- W4386567759 date "2023-09-09" @default.
- W4386567759 modified "2023-09-26" @default.
- W4386567759 title "An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells" @default.
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- W4386567759 doi "https://doi.org/10.1101/2023.09.08.556877" @default.
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