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• W4386567995 endingPage "140138" @default.
• W4386567995 startingPage "140138" @default.
• W4386567995 abstract "Lead (Pb) exposure is well recognized as a significant environmental factor associated with the high incidence of cardiovascular diseases. However, the carriers and molecular targets of Pb in human blood remain to be understood, especially for a real Pb exposure scenario. In this study, a total of 350 blood samples were collected from the smelting workers and systematically analyzed using metallomics and metalloproteomics approaches. The results showed that the majority of Pb (∼99.4%) could be presented in the red blood cells (RBCs). Pb in the cytoplasm of RBCs accounted for approximately 83.1% of the total blood Pb, with nearly half of Pb being bound to proteins. Pb-binding proteins in the blood of workers were identified as hemoglobin, catalase, haptoglobin, δ-aminolevulinic acid dehydratase, and peroxiredoxin-2. Multiple linear regression analyses demonstrated that higher levels of Pb bound to proteins (Mix-bound Pb and Protein-bound Pb) were positively associated with higher systolic blood pressure (p < 0.05). However, the association between blood lead level, Pb levels in the blood cells and systolic blood pressure was not observed (p > 0.05). This study suggested that Pb bound to proteins could be a suitable biomarker for indicating the potential risk of occupational hypertension." @default.
• W4386567995 created "2023-09-10" @default.
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• W4386567995 date "2023-11-01" @default.
• W4386567995 modified "2023-10-12" @default.
• W4386567995 title "Identification of lead-binding proteins as carriers and potential molecular targets associated with systolic blood pressure" @default.
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• W4386567995 doi "https://doi.org/10.1016/j.chemosphere.2023.140138" @default.
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• W4386567995 hasPublicationYear "2023" @default.
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