Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386568098> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4386568098 endingPage "109641" @default.
- W4386568098 startingPage "109641" @default.
- W4386568098 abstract "Corneal activated keratocytes (CAKs) -representing the injured phenotype of corneal stromal cells-are associated with several corneal diseases. Inflammatory cytokines are the key drivers of CAK formation subsequently leading to fibrogenesis. This study aimed to investigate the effect of adlay seed extract on the expression of genes involved in inflammation (IL-6, IL-1b, LIF) and fibrogenesis (TGF-β) in CAK cells. CAKs (106 cells/10 cm2) were exposed to methanolic (MeOH) and residual (Res) extract of adlay seed (1 mg/ml, 24 h). The control group received the vehicle solution without extract at the same time and condition. Then, RNA extraction, cDNA synthesis, and real-time PCR were performed to quantify the relative expression of IL-6, IL-1b, LIF, and TGF-β in the treated vs control cells. This study showed that the MeOH extract of adlay seed could significantly downregulate the expression of IL-6 and IL-1b in the CAKs, while the Res extract led to a significant decrease in TGF-β gene expression. We showed that CAK treatment with adlay seed extract could decrease the expression of genes related to inflammation and fibrogenesis. However, the genes to be targeted depended on the method of extraction. This proof-of-concept study could provide groundwork for the treatment of corneal stromal diseases and ocular regenerative medicine in the future." @default.
- W4386568098 created "2023-09-10" @default.
- W4386568098 creator A5012145685 @default.
- W4386568098 creator A5029723508 @default.
- W4386568098 creator A5090672569 @default.
- W4386568098 creator A5092831619 @default.
- W4386568098 creator A5092831620 @default.
- W4386568098 date "2023-10-01" @default.
- W4386568098 modified "2023-09-27" @default.
- W4386568098 title "Effect of adlay seed extract on inflammation and fibrogenesis in human corneal activated keratocytes at transcriptional level" @default.
- W4386568098 cites W1964334815 @default.
- W4386568098 cites W1971678203 @default.
- W4386568098 cites W1996964253 @default.
- W4386568098 cites W2011405727 @default.
- W4386568098 cites W2024761721 @default.
- W4386568098 cites W2039016753 @default.
- W4386568098 cites W2039705282 @default.
- W4386568098 cites W2042851093 @default.
- W4386568098 cites W2048141990 @default.
- W4386568098 cites W2092931106 @default.
- W4386568098 cites W2093630633 @default.
- W4386568098 cites W2112980158 @default.
- W4386568098 cites W2120729063 @default.
- W4386568098 cites W2190611598 @default.
- W4386568098 cites W2316463616 @default.
- W4386568098 cites W2318358510 @default.
- W4386568098 cites W2942530305 @default.
- W4386568098 cites W2982304991 @default.
- W4386568098 cites W2989910534 @default.
- W4386568098 cites W3007778391 @default.
- W4386568098 cites W3084016656 @default.
- W4386568098 cites W4205583174 @default.
- W4386568098 cites W4211013645 @default.
- W4386568098 doi "https://doi.org/10.1016/j.exer.2023.109641" @default.
- W4386568098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37696465" @default.
- W4386568098 hasPublicationYear "2023" @default.
- W4386568098 type Work @default.
- W4386568098 citedByCount "0" @default.
- W4386568098 crossrefType "journal-article" @default.
- W4386568098 hasAuthorship W4386568098A5012145685 @default.
- W4386568098 hasAuthorship W4386568098A5029723508 @default.
- W4386568098 hasAuthorship W4386568098A5090672569 @default.
- W4386568098 hasAuthorship W4386568098A5092831619 @default.
- W4386568098 hasAuthorship W4386568098A5092831620 @default.
- W4386568098 hasConcept C104317684 @default.
- W4386568098 hasConcept C118131993 @default.
- W4386568098 hasConcept C127561419 @default.
- W4386568098 hasConcept C127716648 @default.
- W4386568098 hasConcept C150194340 @default.
- W4386568098 hasConcept C153911025 @default.
- W4386568098 hasConcept C16930146 @default.
- W4386568098 hasConcept C185592680 @default.
- W4386568098 hasConcept C203014093 @default.
- W4386568098 hasConcept C2776914184 @default.
- W4386568098 hasConcept C502942594 @default.
- W4386568098 hasConcept C55493867 @default.
- W4386568098 hasConcept C556039675 @default.
- W4386568098 hasConcept C67705224 @default.
- W4386568098 hasConcept C71924100 @default.
- W4386568098 hasConcept C86803240 @default.
- W4386568098 hasConcept C95444343 @default.
- W4386568098 hasConceptScore W4386568098C104317684 @default.
- W4386568098 hasConceptScore W4386568098C118131993 @default.
- W4386568098 hasConceptScore W4386568098C127561419 @default.
- W4386568098 hasConceptScore W4386568098C127716648 @default.
- W4386568098 hasConceptScore W4386568098C150194340 @default.
- W4386568098 hasConceptScore W4386568098C153911025 @default.
- W4386568098 hasConceptScore W4386568098C16930146 @default.
- W4386568098 hasConceptScore W4386568098C185592680 @default.
- W4386568098 hasConceptScore W4386568098C203014093 @default.
- W4386568098 hasConceptScore W4386568098C2776914184 @default.
- W4386568098 hasConceptScore W4386568098C502942594 @default.
- W4386568098 hasConceptScore W4386568098C55493867 @default.
- W4386568098 hasConceptScore W4386568098C556039675 @default.
- W4386568098 hasConceptScore W4386568098C67705224 @default.
- W4386568098 hasConceptScore W4386568098C71924100 @default.
- W4386568098 hasConceptScore W4386568098C86803240 @default.
- W4386568098 hasConceptScore W4386568098C95444343 @default.
- W4386568098 hasFunder F4320322545 @default.
- W4386568098 hasLocation W43865680981 @default.
- W4386568098 hasLocation W43865680982 @default.
- W4386568098 hasOpenAccess W4386568098 @default.
- W4386568098 hasPrimaryLocation W43865680981 @default.
- W4386568098 hasRelatedWork W1516968396 @default.
- W4386568098 hasRelatedWork W1647925169 @default.
- W4386568098 hasRelatedWork W2009966535 @default.
- W4386568098 hasRelatedWork W2019988726 @default.
- W4386568098 hasRelatedWork W2082530227 @default.
- W4386568098 hasRelatedWork W2088063203 @default.
- W4386568098 hasRelatedWork W2121331980 @default.
- W4386568098 hasRelatedWork W2171277769 @default.
- W4386568098 hasRelatedWork W2185890143 @default.
- W4386568098 hasRelatedWork W2593242044 @default.
- W4386568098 hasVolume "235" @default.
- W4386568098 isParatext "false" @default.
- W4386568098 isRetracted "false" @default.
- W4386568098 workType "article" @default.