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- W4386568447 abstract "α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons, respectively. Previous works have revealed that intracellular deposition of α-synuclein and/or tau causes many neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Despite intense investigation, the normal physiological functions and roles of α-synuclein and tau are still unclear, owing to the fact that mice with knockout of either of these proteins do not present apparent phenotypes. Interestingly, the co-occurrence of α-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies, some of which share similarities in clinical manifestations. Furthermore, the direct interaction of α-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in vivo. On the other hand, our recent findings have revealed that α-synuclein and tau are cooperatively involved in brain development in a stage-dependent manner. These findings indicate strong cross-talk between the two proteins in physiology and pathology. In this review, we provide a summary of the recent findings on the functional roles of α-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases. A deep understanding of the interplay between α-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases." @default.
- W4386568447 created "2023-09-10" @default.
- W4386568447 creator A5016311678 @default.
- W4386568447 creator A5033146980 @default.
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- W4386568447 creator A5047479397 @default.
- W4386568447 creator A5078372084 @default.
- W4386568447 creator A5091150240 @default.
- W4386568447 date "2023-09-04" @default.
- W4386568447 modified "2023-10-17" @default.
- W4386568447 title "Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system" @default.
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