FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386568863> ?p ?o ?g. }

• W4386568863 abstract "Abstract Behavioural flexibility plays a major role in the way animals cope with novel situations, and physiological stress responses are adaptive and highly efficient mechanisms to cope with unpredictable events. Previous studies investigating the role of stress responses in mediating behavioural flexibility were mostly done in laboratory rodents using stressors and cognitive challenges unrelated to the ecology of the species. To better understand how stress mediates behavioural flexibility in a natural context, direct manipulation of the stress response and cognitive tests in ecologically relevant contexts are needed. To this aim, we pharmacologically blocked glucocorticoid receptors (GR) in adult cichlid fish using a minimally invasive application of a GR antagonist. GRs blockade prevents the termination of the stress response, which we predicted to impair behavioural flexibility. After the application of the GR antagonist, we repeatedly exposed fish to a predator and tested their behavioural flexibility using a detour task, i.e. fish had to find a new, longer route to the shelter when the shortest route was blocked. While the latencies to find the shelter were not different between treatments, GR blocked fish showed more failed attempts during the detour tasks than control fish. Furthermore, reduced performance was accompanied by an increase of fear related behaviours. This suggests that blocking GRs plays an important role in determining perceived fear and resulted in an impaired behavioural flexibility. We confirm a causal role of terminating the stress response in mediating behavioural flexibility with potential consequences for an effective and adaptive coping with changing environments." @default.
• W4386568863 created "2023-09-10" @default.
• W4386568863 creator A5003544092 @default.
• W4386568863 creator A5027518222 @default.
• W4386568863 creator A5028955075 @default.
• W4386568863 creator A5029825716 @default.
• W4386568863 creator A5046614829 @default.
• W4386568863 creator A5092831805 @default.
• W4386568863 date "2023-09-09" @default.
• W4386568863 modified "2023-09-30" @default.
• W4386568863 title "The role of the stress axis in mediating behavioural flexibility in a social cichlid, Neolamprologus pulcher" @default.
• W4386568863 cites W1951724000 @default.
• W4386568863 cites W1973404922 @default.
• W4386568863 cites W1981748148 @default.
• W4386568863 cites W1989270738 @default.
• W4386568863 cites W1993095204 @default.
• W4386568863 cites W1996642120 @default.
• W4386568863 cites W2002456558 @default.
• W4386568863 cites W2003185538 @default.
• W4386568863 cites W2007314124 @default.
• W4386568863 cites W2009549110 @default.
• W4386568863 cites W2012294691 @default.
• W4386568863 cites W2014952282 @default.
• W4386568863 cites W2024726045 @default.
• W4386568863 cites W2027425473 @default.
• W4386568863 cites W2032429852 @default.
• W4386568863 cites W2036973718 @default.
• W4386568863 cites W2040624599 @default.
• W4386568863 cites W2058810543 @default.
• W4386568863 cites W2082994379 @default.
• W4386568863 cites W2084845382 @default.
• W4386568863 cites W2092446867 @default.
• W4386568863 cites W2094183267 @default.
• W4386568863 cites W2110419377 @default.
• W4386568863 cites W2112204642 @default.
• W4386568863 cites W2116582433 @default.
• W4386568863 cites W2116629441 @default.
• W4386568863 cites W2122836078 @default.
• W4386568863 cites W2136738316 @default.
• W4386568863 cites W2141088337 @default.
• W4386568863 cites W2142427400 @default.
• W4386568863 cites W2142905600 @default.
• W4386568863 cites W2148731425 @default.
• W4386568863 cites W2151558704 @default.
• W4386568863 cites W2159014884 @default.
• W4386568863 cites W2159201868 @default.
• W4386568863 cites W2162211493 @default.
• W4386568863 cites W2163539044 @default.
• W4386568863 cites W2259396992 @default.
• W4386568863 cites W2332187642 @default.
• W4386568863 cites W2336785572 @default.
• W4386568863 cites W2346578806 @default.
• W4386568863 cites W2477326737 @default.
• W4386568863 cites W2606499136 @default.
• W4386568863 cites W2750202661 @default.
• W4386568863 cites W2762546589 @default.
• W4386568863 cites W2785482905 @default.
• W4386568863 cites W2787054606 @default.
• W4386568863 cites W2917303293 @default.
• W4386568863 cites W2998395858 @default.
• W4386568863 cites W3083667799 @default.
• W4386568863 cites W3112539874 @default.
• W4386568863 cites W3166969655 @default.
• W4386568863 cites W4237012674 @default.
• W4386568863 cites W4242584517 @default.
• W4386568863 cites W4245897763 @default.
• W4386568863 cites W4280599828 @default.
• W4386568863 cites W4285676376 @default.
• W4386568863 doi "https://doi.org/10.1101/2023.09.07.556642" @default.
• W4386568863 hasPublicationYear "2023" @default.
• W4386568863 type Work @default.
• W4386568863 citedByCount "0" @default.
• W4386568863 crossrefType "posted-content" @default.
• W4386568863 hasAuthorship W4386568863A5003544092 @default.
• W4386568863 hasAuthorship W4386568863A5027518222 @default.
• W4386568863 hasAuthorship W4386568863A5028955075 @default.
• W4386568863 hasAuthorship W4386568863A5029825716 @default.
• W4386568863 hasAuthorship W4386568863A5046614829 @default.
• W4386568863 hasAuthorship W4386568863A5092831805 @default.
• W4386568863 hasConcept C105795698 @default.
• W4386568863 hasConcept C125370674 @default.
• W4386568863 hasConcept C138496976 @default.
• W4386568863 hasConcept C15744967 @default.
• W4386568863 hasConcept C169760540 @default.
• W4386568863 hasConcept C169900460 @default.
• W4386568863 hasConcept C18903297 @default.
• W4386568863 hasConcept C2778284828 @default.
• W4386568863 hasConcept C2780598303 @default.
• W4386568863 hasConcept C2909208804 @default.
• W4386568863 hasConcept C33923547 @default.
• W4386568863 hasConcept C505870484 @default.
• W4386568863 hasConcept C66102695 @default.
• W4386568863 hasConcept C86803240 @default.
• W4386568863 hasConceptScore W4386568863C105795698 @default.
• W4386568863 hasConceptScore W4386568863C125370674 @default.
• W4386568863 hasConceptScore W4386568863C138496976 @default.
• W4386568863 hasConceptScore W4386568863C15744967 @default.
• W4386568863 hasConceptScore W4386568863C169760540 @default.
• W4386568863 hasConceptScore W4386568863C169900460 @default.
• W4386568863 hasConceptScore W4386568863C18903297 @default.

• next