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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386569939> ?p ?o ?g. }

• W4386569939 endingPage "e20011" @default.
• W4386569939 startingPage "e20011" @default.
• W4386569939 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused 403 million cases of coronavirus disease (COVID-19) and resulted in more than 5.7 million deaths worldwide. Extensive research has identified several potential drug treatments for COVID-19. However, the development of new compounds or therapies is necessary to prevent the emergence of drug resistance in SARS-CoV-2. In this study, a novel compound based on hexaacetotetraaquadihydroxochromium(III)diiron(III) nitrate, which contains small amounts of chromium (III), was synthesised and evaluated for its effectiveness against multiple variants of COVID-19 using both in vitro and in vivo models. This innovative compound demonstrated interference with the interaction between the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2). Furthermore, in vitro experiments showed that this compound downregulated the expression of ACE2 and transmembrane serine protease 2 (TMPRSS2). It also exhibited a reduction in the activity of 3-chymotrypsin-like protease (3CL) and RNA-dependent RNA polymerase (RdRp). Pretreatment with this small chromium (III)-based compound resulted in reduced ACE2-rich cell infection by various variants of SARS-CoV-2 spike protein-pseudotyped lentivirus. Finally, the compound effectively inhibited viral infection by multiple variants of SARS-CoV-2 spike protein-pseudotyped lentivirus in both the abdominal and thoracic regions of mice. In conclusion, this compound lowers the likelihood of SARS-CoV-2 entry into cells, inhibits viral maturation and replication in vitro, and reduces infection levels of multiple variants of SARS-CoV-2 spike protein-pseudotyped lentivirus in the abdomen and thorax following pretreatment. Small chromium (III)-based compounds have the potential to restrict the progression of SARS-CoV-2 infections." @default.
• W4386569939 created "2023-09-10" @default.
• W4386569939 creator A5025617602 @default.
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• W4386569939 date "2023-09-01" @default.
• W4386569939 modified "2023-10-12" @default.
• W4386569939 title "Development and evaluation of a novel chromium III-based compound for potential inhibition of emerging SARS-CoV-2 variants" @default.
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• W4386569939 doi "https://doi.org/10.1016/j.heliyon.2023.e20011" @default.
• W4386569939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37809843" @default.
• W4386569939 hasPublicationYear "2023" @default.
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