Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386569944> ?p ?o ?g. }
- W4386569944 endingPage "107865" @default.
- W4386569944 startingPage "107865" @default.
- W4386569944 abstract "The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light entrainment via vasoactive intestinal peptide (VIP) neurons (SCNVIP). Yet, how these neurons uniquely respond and connect to intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing melanopsin (Opn4) has not been determined functionally in freely behaving animals. To address this, we first used monosynaptic tracing from SCNVIP neurons in mice and identified two SCNVIP subpopulations. Second, we recorded calcium changes in response to ambient light, at both bulk and single-cell levels, and found two unique activity patterns in response to high- and low-intensity blue light. The activity patterns of both subpopulations could be manipulated by application of an Opn4 antagonist. These results suggest that the two SCNVIP subpopulations connect to two types of Opn4-expressing ipRGCs, likely M1 and M2, but only one is responsive to red light. These findings have important implications for our basic understanding of non-image-forming circadian light processing." @default.
- W4386569944 created "2023-09-10" @default.
- W4386569944 creator A5003360192 @default.
- W4386569944 creator A5006785266 @default.
- W4386569944 creator A5044473714 @default.
- W4386569944 creator A5050240445 @default.
- W4386569944 creator A5052164643 @default.
- W4386569944 creator A5077818522 @default.
- W4386569944 date "2023-10-01" @default.
- W4386569944 modified "2023-10-17" @default.
- W4386569944 title "Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons" @default.
- W4386569944 cites W1560950175 @default.
- W4386569944 cites W1574673451 @default.
- W4386569944 cites W1862406226 @default.
- W4386569944 cites W1875506666 @default.
- W4386569944 cites W1969631412 @default.
- W4386569944 cites W1991944917 @default.
- W4386569944 cites W1995481744 @default.
- W4386569944 cites W1997015033 @default.
- W4386569944 cites W2005542815 @default.
- W4386569944 cites W2008213690 @default.
- W4386569944 cites W2009077913 @default.
- W4386569944 cites W2010323016 @default.
- W4386569944 cites W2015731785 @default.
- W4386569944 cites W2021317668 @default.
- W4386569944 cites W2022197238 @default.
- W4386569944 cites W2035688662 @default.
- W4386569944 cites W2035853180 @default.
- W4386569944 cites W2041656098 @default.
- W4386569944 cites W2042305934 @default.
- W4386569944 cites W2049677726 @default.
- W4386569944 cites W2052034821 @default.
- W4386569944 cites W2055665132 @default.
- W4386569944 cites W2058709834 @default.
- W4386569944 cites W2068391384 @default.
- W4386569944 cites W2070154168 @default.
- W4386569944 cites W2072416063 @default.
- W4386569944 cites W2073028192 @default.
- W4386569944 cites W2078677652 @default.
- W4386569944 cites W2103951666 @default.
- W4386569944 cites W2105050095 @default.
- W4386569944 cites W2106496774 @default.
- W4386569944 cites W2107083462 @default.
- W4386569944 cites W2164003143 @default.
- W4386569944 cites W2259648020 @default.
- W4386569944 cites W2265560249 @default.
- W4386569944 cites W2297575556 @default.
- W4386569944 cites W2389771398 @default.
- W4386569944 cites W2415509130 @default.
- W4386569944 cites W2583510643 @default.
- W4386569944 cites W2611374133 @default.
- W4386569944 cites W2621355886 @default.
- W4386569944 cites W2623791013 @default.
- W4386569944 cites W2751437253 @default.
- W4386569944 cites W2803756662 @default.
- W4386569944 cites W2884574861 @default.
- W4386569944 cites W2885548393 @default.
- W4386569944 cites W2969965946 @default.
- W4386569944 cites W2977113150 @default.
- W4386569944 cites W2996606637 @default.
- W4386569944 cites W3005834749 @default.
- W4386569944 cites W3009125107 @default.
- W4386569944 cites W3082037178 @default.
- W4386569944 cites W3088825344 @default.
- W4386569944 cites W3094071224 @default.
- W4386569944 cites W3127490885 @default.
- W4386569944 cites W3164743632 @default.
- W4386569944 cites W3165387765 @default.
- W4386569944 cites W3199363329 @default.
- W4386569944 cites W3204546288 @default.
- W4386569944 cites W3215420523 @default.
- W4386569944 cites W4285007491 @default.
- W4386569944 cites W4317437921 @default.
- W4386569944 cites W4318071669 @default.
- W4386569944 cites W560233946 @default.
- W4386569944 doi "https://doi.org/10.1016/j.isci.2023.107865" @default.
- W4386569944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37766975" @default.
- W4386569944 hasPublicationYear "2023" @default.
- W4386569944 type Work @default.
- W4386569944 citedByCount "0" @default.
- W4386569944 crossrefType "journal-article" @default.
- W4386569944 hasAuthorship W4386569944A5003360192 @default.
- W4386569944 hasAuthorship W4386569944A5006785266 @default.
- W4386569944 hasAuthorship W4386569944A5044473714 @default.
- W4386569944 hasAuthorship W4386569944A5050240445 @default.
- W4386569944 hasAuthorship W4386569944A5052164643 @default.
- W4386569944 hasAuthorship W4386569944A5077818522 @default.
- W4386569944 hasBestOaLocation W43865699441 @default.
- W4386569944 hasConcept C118303440 @default.
- W4386569944 hasConcept C121446783 @default.
- W4386569944 hasConcept C126322002 @default.
- W4386569944 hasConcept C135343436 @default.
- W4386569944 hasConcept C139992725 @default.
- W4386569944 hasConcept C169760540 @default.
- W4386569944 hasConcept C170493617 @default.
- W4386569944 hasConcept C189780591 @default.
- W4386569944 hasConcept C201176492 @default.
- W4386569944 hasConcept C2777093970 @default.