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- W4386570670 endingPage "110861" @default.
- W4386570670 startingPage "110861" @default.
- W4386570670 abstract "There is a lot of evidence establishing that nervous system development is related to the composition and functions of the gut microbiome. In addition, the central nervous system (CNS) controls the imbalance of the intestinal microbiota, constituting a bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine and neural circuits via the vagal pathway. Several empirical data have associated gut microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism and Parkinson's disease, and with other psychological disorders like anxiety, depression, and cognitive dysfunctions. Fecal microbiota transplantation (FMT) therapy has shown that the gut microbiota can transfer behavioral features to recipient animals, which provides strong evidence to establish a causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, have demonstrated an important influence of microbiota on neurological disorders by both the synthesis of neuroactive compounds that interact with the nervous system and by the regulation of inflammatory and endocrine processes. Further research is needed to demonstrate the influence of gut microbiota dysbiosis on psychiatric and psychological disorders, and how microbiota-based interventions may be used as potential therapeutic tools." @default.
- W4386570670 created "2023-09-10" @default.
- W4386570670 creator A5048432346 @default.
- W4386570670 creator A5092014276 @default.
- W4386570670 date "2024-01-01" @default.
- W4386570670 modified "2023-10-08" @default.
- W4386570670 title "An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders" @default.
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