Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386571024> ?p ?o ?g. }
- W4386571024 endingPage "106915" @default.
- W4386571024 startingPage "106915" @default.
- W4386571024 abstract "Ferroptosis has been suggested to play a potential role in cancer therapy as an iron-dependent programmed cell death mechanism distinct from other forms. Hepatocellular carcinoma (HCC) remains a great threat, with high mortality and limited therapeutic options. The induction of ferroptosis has emerged as a novel and promising therapeutic strategy for HCC. In the present study, we identified protein inhibitor of activated STAT3 (PIAS3) as a driver of ferroptosis in HCC using TMT-based quantitative proteomics and ferroptosis-related functional assays. Mechanistically, thioredoxin-interacting protein (TXNIP) was confirmed to be PIAS3 in promoting ferroptotic cell death, based on RNA-seq analysis. Knockdown of TXNIP degrades ferroptotic susceptibility caused by PIAS3-overexpression, whereas transfection-forced reexpression of TXNIP restores sensitivity to ferroptosis in PIAS3-downregulated cells. PIAS3 interacts with SMAD2/3 to activate transforming growth factor (TGF)-β signaling, leading to increased TXNIP expression. Our study revealed the critical role of PIAS3 in ferroptosis and a novel actionable axis-PIAS3/TGF-β/TXNIP that could govern ferroptotic sensitivity, paving the path for using ferroptosis as an efficient approach in HCC therapies." @default.
- W4386571024 created "2023-09-10" @default.
- W4386571024 creator A5034190557 @default.
- W4386571024 creator A5060280961 @default.
- W4386571024 creator A5067235802 @default.
- W4386571024 creator A5070584261 @default.
- W4386571024 creator A5089407195 @default.
- W4386571024 date "2023-10-01" @default.
- W4386571024 modified "2023-10-05" @default.
- W4386571024 title "PIAS3 promotes ferroptosis by regulating TXNIP via TGF-β signaling pathway in hepatocellular carcinoma" @default.
- W4386571024 cites W1513392008 @default.
- W4386571024 cites W1966558019 @default.
- W4386571024 cites W1982574573 @default.
- W4386571024 cites W1993520606 @default.
- W4386571024 cites W1997183854 @default.
- W4386571024 cites W1997309935 @default.
- W4386571024 cites W2047446944 @default.
- W4386571024 cites W2102278945 @default.
- W4386571024 cites W2105106534 @default.
- W4386571024 cites W2107060225 @default.
- W4386571024 cites W2114489856 @default.
- W4386571024 cites W2127597058 @default.
- W4386571024 cites W2139462220 @default.
- W4386571024 cites W2144581250 @default.
- W4386571024 cites W2315534050 @default.
- W4386571024 cites W2533894695 @default.
- W4386571024 cites W2550324626 @default.
- W4386571024 cites W2606367731 @default.
- W4386571024 cites W2606960481 @default.
- W4386571024 cites W2611610643 @default.
- W4386571024 cites W2762087180 @default.
- W4386571024 cites W2791950390 @default.
- W4386571024 cites W2803724343 @default.
- W4386571024 cites W2805592007 @default.
- W4386571024 cites W2897111276 @default.
- W4386571024 cites W2905985027 @default.
- W4386571024 cites W2937823726 @default.
- W4386571024 cites W2972164676 @default.
- W4386571024 cites W2980472864 @default.
- W4386571024 cites W3013967177 @default.
- W4386571024 cites W3023772547 @default.
- W4386571024 cites W3031002866 @default.
- W4386571024 cites W3087642771 @default.
- W4386571024 cites W3095941442 @default.
- W4386571024 cites W3109926818 @default.
- W4386571024 cites W3123922203 @default.
- W4386571024 cites W3125788801 @default.
- W4386571024 cites W3126428861 @default.
- W4386571024 cites W3128646645 @default.
- W4386571024 cites W3133823534 @default.
- W4386571024 cites W3164515442 @default.
- W4386571024 cites W3185747952 @default.
- W4386571024 cites W3200459204 @default.
- W4386571024 cites W3215753091 @default.
- W4386571024 cites W4200614050 @default.
- W4386571024 cites W4206643809 @default.
- W4386571024 cites W4210535677 @default.
- W4386571024 cites W4210774372 @default.
- W4386571024 cites W4284889683 @default.
- W4386571024 doi "https://doi.org/10.1016/j.phrs.2023.106915" @default.
- W4386571024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37689128" @default.
- W4386571024 hasPublicationYear "2023" @default.
- W4386571024 type Work @default.
- W4386571024 citedByCount "0" @default.
- W4386571024 crossrefType "journal-article" @default.
- W4386571024 hasAuthorship W4386571024A5034190557 @default.
- W4386571024 hasAuthorship W4386571024A5060280961 @default.
- W4386571024 hasAuthorship W4386571024A5067235802 @default.
- W4386571024 hasAuthorship W4386571024A5070584261 @default.
- W4386571024 hasAuthorship W4386571024A5089407195 @default.
- W4386571024 hasBestOaLocation W43865710241 @default.
- W4386571024 hasConcept C104317684 @default.
- W4386571024 hasConcept C127561419 @default.
- W4386571024 hasConcept C173396325 @default.
- W4386571024 hasConcept C190283241 @default.
- W4386571024 hasConcept C2776151105 @default.
- W4386571024 hasConcept C2779076967 @default.
- W4386571024 hasConcept C2908690268 @default.
- W4386571024 hasConcept C31573885 @default.
- W4386571024 hasConcept C3623737 @default.
- W4386571024 hasConcept C502942594 @default.
- W4386571024 hasConcept C55493867 @default.
- W4386571024 hasConcept C62478195 @default.
- W4386571024 hasConcept C86803240 @default.
- W4386571024 hasConcept C95444343 @default.
- W4386571024 hasConceptScore W4386571024C104317684 @default.
- W4386571024 hasConceptScore W4386571024C127561419 @default.
- W4386571024 hasConceptScore W4386571024C173396325 @default.
- W4386571024 hasConceptScore W4386571024C190283241 @default.
- W4386571024 hasConceptScore W4386571024C2776151105 @default.
- W4386571024 hasConceptScore W4386571024C2779076967 @default.
- W4386571024 hasConceptScore W4386571024C2908690268 @default.
- W4386571024 hasConceptScore W4386571024C31573885 @default.
- W4386571024 hasConceptScore W4386571024C3623737 @default.
- W4386571024 hasConceptScore W4386571024C502942594 @default.
- W4386571024 hasConceptScore W4386571024C55493867 @default.
- W4386571024 hasConceptScore W4386571024C62478195 @default.
- W4386571024 hasConceptScore W4386571024C86803240 @default.