FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386571085> ?p ?o ?g. }

• W4386571085 abstract "Reverse genetic studies conducted in the plant with a complex or polyploidy genome enriched with large gene families (like wheat) often meet challenges in identifying the key candidate genes related to important traits and prioritizing the genes for functional experiments.To overcome the above-mentioned challenges of reverse genetics, this work aims to establish an efficient multi-species strategy for genome-wide gene identification and prioritization of the key candidate genes.We established the integrative gene duplication and genome-wide analysis (iGG analysis) as a strategy for pinpointing key candidate genes deserving functional research. The iGG captures the evolution, and the expansion/contraction of large gene families across phylogeny-related species and integrates spatial-temporal expression information for gene function inference. Transgenic approaches were also employed to functional validation.As a proof-of-concept for the iGG analysis, we took the wheat calcineurin B-like protein-interacting protein kinases (CIPKs) family as an example. We identified CIPKs from seven monocot species, established the orthologous relationship of CIPKs between rice and wheat, and characterized Triticeae-specific CIPK duplicates (e.g., CIPK4 and CIPK17). Integrated with our analysis of CBLs and CBL-CIPK interaction, we revealed that divergent expressions of TaCBLs and TaCIPKs could play an important role in keeping the stoichiometric balance of CBL-CIPK. Furthermore, we validated the function of TaCIPK17-A2 in the regulation of drought tolerance by using transgenic approaches. Overexpression of TaCIPK17 enhanced antioxidant capacity and improved drought tolerance in wheat.The iGG analysis leverages evolutionary and comparative genomics of crops with large genomes to rapidly highlight the duplicated genes potentially associated with speciation, domestication and/or particular traits that deserve reverse-genetic functional studies. Through the identification of Triticeae-specific TaCIPK17 duplicates and functional validation, we demonstrated the effectiveness of the iGG analysis and provided a new target gene for improving drought tolerance in wheat." @default.
• W4386571085 created "2023-09-10" @default.
• W4386571085 creator A5002848127 @default.
• W4386571085 creator A5011210381 @default.
• W4386571085 creator A5011281136 @default.
• W4386571085 creator A5011643959 @default.
• W4386571085 creator A5037209797 @default.
• W4386571085 creator A5042232273 @default.
• W4386571085 creator A5052441498 @default.
• W4386571085 creator A5060775470 @default.
• W4386571085 creator A5060840394 @default.
• W4386571085 creator A5073922441 @default.
• W4386571085 creator A5080284521 @default.
• W4386571085 creator A5081428797 @default.
• W4386571085 creator A5084434060 @default.
• W4386571085 creator A5085576050 @default.
• W4386571085 date "2023-09-01" @default.
• W4386571085 modified "2023-09-29" @default.
• W4386571085 title "Integrative gene duplication and genome-wide analysis as an approach to facilitate wheat reverse genetics: an example in the TaCIPK family" @default.
• W4386571085 cites W1562315224 @default.
• W4386571085 cites W1709815505 @default.
• W4386571085 cites W1892997619 @default.
• W4386571085 cites W1968881709 @default.
• W4386571085 cites W1989243728 @default.
• W4386571085 cites W1990813498 @default.
• W4386571085 cites W1993616323 @default.
• W4386571085 cites W2001374342 @default.
• W4386571085 cites W2009457709 @default.
• W4386571085 cites W2017218227 @default.
• W4386571085 cites W2019634500 @default.
• W4386571085 cites W2027641855 @default.
• W4386571085 cites W2031515893 @default.
• W4386571085 cites W2047806985 @default.
• W4386571085 cites W2049394588 @default.
• W4386571085 cites W2052903078 @default.
• W4386571085 cites W2066821556 @default.
• W4386571085 cites W2068090568 @default.
• W4386571085 cites W2091964834 @default.
• W4386571085 cites W2097245357 @default.
• W4386571085 cites W2104179862 @default.
• W4386571085 cites W2104213175 @default.
• W4386571085 cites W2109975826 @default.
• W4386571085 cites W2110042203 @default.
• W4386571085 cites W2113102777 @default.
• W4386571085 cites W2138471074 @default.
• W4386571085 cites W2142711902 @default.
• W4386571085 cites W2157882076 @default.
• W4386571085 cites W2159664363 @default.
• W4386571085 cites W2301290620 @default.
• W4386571085 cites W2418223933 @default.
• W4386571085 cites W2421805366 @default.
• W4386571085 cites W2492979942 @default.
• W4386571085 cites W2513364632 @default.
• W4386571085 cites W2557156880 @default.
• W4386571085 cites W2572395344 @default.
• W4386571085 cites W2726347871 @default.
• W4386571085 cites W2756453241 @default.
• W4386571085 cites W2768703572 @default.
• W4386571085 cites W2770565810 @default.
• W4386571085 cites W2775186419 @default.
• W4386571085 cites W2776651929 @default.
• W4386571085 cites W2799524357 @default.
• W4386571085 cites W2803066701 @default.
• W4386571085 cites W2804707253 @default.
• W4386571085 cites W2809143220 @default.
• W4386571085 cites W2886541918 @default.
• W4386571085 cites W2886785109 @default.
• W4386571085 cites W2888105356 @default.
• W4386571085 cites W2895074862 @default.
• W4386571085 cites W2902412573 @default.
• W4386571085 cites W2931575838 @default.
• W4386571085 cites W2943524534 @default.
• W4386571085 cites W2994879940 @default.
• W4386571085 cites W3003011408 @default.
• W4386571085 cites W3012169111 @default.
• W4386571085 cites W3034528666 @default.
• W4386571085 cites W3036319615 @default.
• W4386571085 cites W3042303201 @default.
• W4386571085 cites W3089071526 @default.
• W4386571085 cites W3110323992 @default.
• W4386571085 cites W3128285641 @default.
• W4386571085 cites W3129405656 @default.
• W4386571085 cites W3132243836 @default.
• W4386571085 cites W3159395759 @default.
• W4386571085 cites W3160905138 @default.
• W4386571085 cites W3205328789 @default.
• W4386571085 cites W3210938556 @default.
• W4386571085 cites W4200051657 @default.
• W4386571085 cites W4200135473 @default.
• W4386571085 cites W4206010529 @default.
• W4386571085 cites W4206979352 @default.
• W4386571085 cites W4210626519 @default.
• W4386571085 cites W4283210164 @default.
• W4386571085 cites W4311633557 @default.
• W4386571085 cites W4383371490 @default.
• W4386571085 doi "https://doi.org/10.1016/j.jare.2023.09.005" @default.
• W4386571085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37689241" @default.
• W4386571085 hasPublicationYear "2023" @default.
• W4386571085 type Work @default.
• W4386571085 citedByCount "0" @default.

• next