Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386572724> ?p ?o ?g. }
- W4386572724 abstract "Abstract Background The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations in genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of cancer have revealed many germline risk factors associated with cancer. However, the overlap between known somatic driver genes and positional candidate genes from GWAS loci is surprisingly small. We hypothesised that genes from multiple independent cancer GWAS loci should show tissue-specific co-regulation patterns that converge on cancer-specific driver genes. Results We studied recent well powered GWAS of breast, prostate, colorectal and skin cancer by estimating co-expression between genes and subsequently prioritising genes that show co- expression with genes mapping within susceptibility loci from cancer GWAS. We observed that the prioritised genes were strongly enriched for cancer drivers defined by COSMIC, intOGen and Dietlein et al . The enrichment of known cancer driver genes was most significant when using co-expression networks derived from non-cancer samples from the relevant tissue of origin. Conclusion We show how genes in risk loci identified by cancer GWAS can be linked to known cancer driver genes through tissue-specific co-expression networks. This provides an important explanation for why seemingly unrelated sets of genes that harbour either germline risk factors or somatic mutations can eventually cause the same type of disease." @default.
- W4386572724 created "2023-09-10" @default.
- W4386572724 creator A5006708192 @default.
- W4386572724 creator A5021227407 @default.
- W4386572724 creator A5022697996 @default.
- W4386572724 creator A5043779125 @default.
- W4386572724 creator A5047168944 @default.
- W4386572724 creator A5058939015 @default.
- W4386572724 creator A5071483953 @default.
- W4386572724 creator A5075155340 @default.
- W4386572724 creator A5088404253 @default.
- W4386572724 creator A5088951094 @default.
- W4386572724 creator A5092832794 @default.
- W4386572724 creator A5092832795 @default.
- W4386572724 date "2023-09-08" @default.
- W4386572724 modified "2023-09-30" @default.
- W4386572724 title "Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes" @default.
- W4386572724 cites W1968214033 @default.
- W4386572724 cites W2052677587 @default.
- W4386572724 cites W2072789685 @default.
- W4386572724 cites W2089155477 @default.
- W4386572724 cites W2095909899 @default.
- W4386572724 cites W2103017472 @default.
- W4386572724 cites W2122825543 @default.
- W4386572724 cites W2153860431 @default.
- W4386572724 cites W2158485828 @default.
- W4386572724 cites W2164600784 @default.
- W4386572724 cites W2170073354 @default.
- W4386572724 cites W2179438025 @default.
- W4386572724 cites W2586694861 @default.
- W4386572724 cites W2594091455 @default.
- W4386572724 cites W2626606138 @default.
- W4386572724 cites W2731059153 @default.
- W4386572724 cites W2762272043 @default.
- W4386572724 cites W2766676715 @default.
- W4386572724 cites W2894573839 @default.
- W4386572724 cites W2901303766 @default.
- W4386572724 cites W2922276872 @default.
- W4386572724 cites W2947410234 @default.
- W4386572724 cites W3014963373 @default.
- W4386572724 cites W3024294833 @default.
- W4386572724 cites W3029661147 @default.
- W4386572724 cites W3040338113 @default.
- W4386572724 cites W3047825284 @default.
- W4386572724 cites W3119507732 @default.
- W4386572724 cites W3135522648 @default.
- W4386572724 cites W3138025188 @default.
- W4386572724 cites W3147142721 @default.
- W4386572724 cites W3204758721 @default.
- W4386572724 cites W3205149084 @default.
- W4386572724 cites W3208112576 @default.
- W4386572724 cites W4220918967 @default.
- W4386572724 cites W4224006698 @default.
- W4386572724 cites W4225529913 @default.
- W4386572724 cites W4226036558 @default.
- W4386572724 cites W4283647069 @default.
- W4386572724 cites W4323036511 @default.
- W4386572724 cites W4367836397 @default.
- W4386572724 cites W4381430994 @default.
- W4386572724 cites W4382934497 @default.
- W4386572724 doi "https://doi.org/10.1101/2023.09.08.23295254" @default.
- W4386572724 hasPublicationYear "2023" @default.
- W4386572724 type Work @default.
- W4386572724 citedByCount "0" @default.
- W4386572724 crossrefType "posted-content" @default.
- W4386572724 hasAuthorship W4386572724A5006708192 @default.
- W4386572724 hasAuthorship W4386572724A5021227407 @default.
- W4386572724 hasAuthorship W4386572724A5022697996 @default.
- W4386572724 hasAuthorship W4386572724A5043779125 @default.
- W4386572724 hasAuthorship W4386572724A5047168944 @default.
- W4386572724 hasAuthorship W4386572724A5058939015 @default.
- W4386572724 hasAuthorship W4386572724A5071483953 @default.
- W4386572724 hasAuthorship W4386572724A5075155340 @default.
- W4386572724 hasAuthorship W4386572724A5088404253 @default.
- W4386572724 hasAuthorship W4386572724A5088951094 @default.
- W4386572724 hasAuthorship W4386572724A5092832794 @default.
- W4386572724 hasAuthorship W4386572724A5092832795 @default.
- W4386572724 hasBestOaLocation W43865727241 @default.
- W4386572724 hasConcept C104317684 @default.
- W4386572724 hasConcept C106208931 @default.
- W4386572724 hasConcept C109825262 @default.
- W4386572724 hasConcept C121608353 @default.
- W4386572724 hasConcept C134305767 @default.
- W4386572724 hasConcept C13514818 @default.
- W4386572724 hasConcept C135763542 @default.
- W4386572724 hasConcept C153209595 @default.
- W4386572724 hasConcept C501734568 @default.
- W4386572724 hasConcept C54355233 @default.
- W4386572724 hasConcept C86803240 @default.
- W4386572724 hasConceptScore W4386572724C104317684 @default.
- W4386572724 hasConceptScore W4386572724C106208931 @default.
- W4386572724 hasConceptScore W4386572724C109825262 @default.
- W4386572724 hasConceptScore W4386572724C121608353 @default.
- W4386572724 hasConceptScore W4386572724C134305767 @default.
- W4386572724 hasConceptScore W4386572724C13514818 @default.
- W4386572724 hasConceptScore W4386572724C135763542 @default.
- W4386572724 hasConceptScore W4386572724C153209595 @default.
- W4386572724 hasConceptScore W4386572724C501734568 @default.
- W4386572724 hasConceptScore W4386572724C54355233 @default.
- W4386572724 hasConceptScore W4386572724C86803240 @default.