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- W4386573515 abstract "Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for humans. Here we describe the application of virus-like vesicles (VLV) for delivery of three immunomodulators alone and in combination, as a promising approach for cancer immunotherapy. VLV vectors were designed to deliver single chain interleukin (IL)-12, short-hairpin RNA (shRNA) targeting programmed death ligand 1 (PD-L1), and a dominant-negative form of IL-17 receptor A (dn-IL17RA) as a single payload or as the combination payload. Intralesional delivery of the VLV vector expressing IL-12 alone as well as the trivalent vector (designated CARG-2020) eradicated large established tumors. However, only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice, indicating a benefit of the combined immunomodulation. The abscopal effects of CARG-2020 on the non-injected contralateral tumors, as well as protection from the tumor cell re-challenge, suggest immune-mediated mechanism of protection and establishment of immunological memory. Mechanistically, CARG-2020 potently activates Th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting inflammation. The ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy." @default.
- W4386573515 created "2023-09-10" @default.
- W4386573515 creator A5001013722 @default.
- W4386573515 creator A5015746736 @default.
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- W4386573515 creator A5087192053 @default.
- W4386573515 date "2023-09-01" @default.
- W4386573515 modified "2023-09-27" @default.
- W4386573515 title "Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence" @default.
- W4386573515 cites W1493141130 @default.
- W4386573515 cites W1894716638 @default.
- W4386573515 cites W1940241680 @default.
- W4386573515 cites W1957245242 @default.
- W4386573515 cites W1969945860 @default.
- W4386573515 cites W1970847065 @default.
- W4386573515 cites W1976338969 @default.
- W4386573515 cites W1976899534 @default.
- W4386573515 cites W1979514172 @default.
- W4386573515 cites W1980529587 @default.
- W4386573515 cites W1987375206 @default.
- W4386573515 cites W1987743714 @default.
- W4386573515 cites W1995700626 @default.
- W4386573515 cites W2000114190 @default.
- W4386573515 cites W2009469072 @default.
- W4386573515 cites W2010862338 @default.
- W4386573515 cites W2025459290 @default.
- W4386573515 cites W2032299291 @default.
- W4386573515 cites W2033750865 @default.
- W4386573515 cites W2044748328 @default.
- W4386573515 cites W2045814042 @default.
- W4386573515 cites W2050133902 @default.
- W4386573515 cites W2053939295 @default.
- W4386573515 cites W2054103394 @default.
- W4386573515 cites W2057754694 @default.
- W4386573515 cites W2063561524 @default.
- W4386573515 cites W2066671159 @default.
- W4386573515 cites W2070344272 @default.
- W4386573515 cites W2076543085 @default.
- W4386573515 cites W2081236127 @default.
- W4386573515 cites W2082554712 @default.
- W4386573515 cites W2089015169 @default.
- W4386573515 cites W2090996581 @default.
- W4386573515 cites W2106436551 @default.
- W4386573515 cites W2109274792 @default.
- W4386573515 cites W2118278569 @default.
- W4386573515 cites W2127282925 @default.
- W4386573515 cites W2128799252 @default.
- W4386573515 cites W2134768631 @default.
- W4386573515 cites W2136757803 @default.
- W4386573515 cites W2138209294 @default.
- W4386573515 cites W2151327646 @default.
- W4386573515 cites W2151707711 @default.
- W4386573515 cites W2152159632 @default.
- W4386573515 cites W2156106286 @default.
- W4386573515 cites W2160834915 @default.
- W4386573515 cites W2161967866 @default.
- W4386573515 cites W2166662937 @default.
- W4386573515 cites W2292383635 @default.
- W4386573515 cites W2461097392 @default.
- W4386573515 cites W2554109426 @default.
- W4386573515 cites W2561926137 @default.
- W4386573515 cites W2572160893 @default.
- W4386573515 cites W2576892948 @default.
- W4386573515 cites W2736361365 @default.
- W4386573515 cites W2763151664 @default.
- W4386573515 cites W2771259184 @default.
- W4386573515 cites W2788350317 @default.
- W4386573515 cites W2791483720 @default.
- W4386573515 cites W2889085114 @default.
- W4386573515 cites W2895357007 @default.
- W4386573515 cites W2899134125 @default.
- W4386573515 cites W2914396734 @default.
- W4386573515 cites W2937823726 @default.
- W4386573515 cites W2959497269 @default.
- W4386573515 cites W2973738313 @default.
- W4386573515 cites W2981353644 @default.
- W4386573515 cites W2981718261 @default.
- W4386573515 cites W2988328495 @default.
- W4386573515 cites W2988590615 @default.
- W4386573515 cites W2991102716 @default.
- W4386573515 cites W2999583889 @default.
- W4386573515 cites W3000019484 @default.
- W4386573515 cites W3006398355 @default.
- W4386573515 cites W3033827747 @default.
- W4386573515 cites W3033841996 @default.
- W4386573515 cites W3082256626 @default.
- W4386573515 cites W3087288726 @default.
- W4386573515 cites W3092306917 @default.
- W4386573515 cites W3093225819 @default.
- W4386573515 cites W3093762626 @default.
- W4386573515 cites W3109001488 @default.